{"id":"https://openalex.org/W2390855408","doi":null,"title":"RNA interference inhibits the secretion of IL-1\u03b1 in mice spleen lymphocytes","display_name":"RNA interference inhibits the secretion of IL-1\u03b1 in mice spleen lymphocytes","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2390855408","mag":"2390855408"},"language":"en","primary_location":{"id":"mag:2390855408","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200703006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100758734","display_name":"Haipeng Zhang","orcid":"https://orcid.org/0000-0001-9188-542X","observed_orcids":["https://orcid.org/0000-0001-9188-542X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haipeng Zhang","raw_affiliation_strings":["1Department of Pathophysiology, College of Basic Medical Sciences, 2Department of Anesthesia, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pathophysiology, College of Basic Medical Sciences, 2Department of Anesthesia, The Affiliated Shengjing Hospital, China Medical University, Shenyang 110001, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100758734"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25479633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.996999979019165},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.9190000295639038},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.9359999895095825},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.675000011920929},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7751140594482422},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7603744864463806},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7133631706237793},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6381473541259766},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6241136789321899},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5845212936401367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5821728110313416},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5353899598121643},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4753137230873108},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4152640104293823},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.39998146891593933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2573956251144409},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1933208703994751},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15257695317268372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05616787075996399}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2390855408","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200703006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2369603084","https://openalex.org/W2361891161","https://openalex.org/W906748778","https://openalex.org/W3149378136","https://openalex.org/W2375786131","https://openalex.org/W2366384964","https://openalex.org/W7018864758","https://openalex.org/W2355337648","https://openalex.org/W1972486351","https://openalex.org/W4206818280"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"decide":[2],"the":[3,63,73,80,97,103,124],"effect":[4,114],"that":[5],"selected":[6,94],"siRNA":[7,51],"degrades":[8],"mRNA":[9],"of":[10,15,65,71,82,99,102,126],"IL-1\u03b1":[11,83],"specifically":[12],"and":[13,44,60,79,92,122],"suppression":[14,104],"its":[16],"expression":[17,30,98],"after":[18],"connected":[19],"with":[20,23,90],"target":[21,35,66],"site":[22,36],"homology":[24],"complementary":[25],"sequence.":[26],"METHODS:":[27],"Synthesized":[28],"DNA":[29],"box":[31],"aimed":[32],"directly":[33],"at":[34],"through":[37],"PCR":[38],"reaction":[39],"in":[40,115,119],"vivo":[41],"was":[42,52,77,84,105],"purified,":[43],"transfected":[45],"into":[46],"lymphocytes":[47,118],"stimulated":[48],"by":[49,54],"LPS.":[50],"transcribed":[53],"cellular":[55],"endogenous":[56],"RNA":[57],"polymerase":[58],"\u2162":[59],"then":[61],"evoke":[62],"degradation":[64],"mRNA.":[67],"After":[68],"48":[69],"hours":[70],"transfection,":[72],"cell":[74],"culture":[75,121],"supernatant":[76],"collected":[78],"concentration":[81],"assayed":[85],"using":[86],"ELISA.":[87],"RESULTS:":[88],"Compared":[89],"blank-control":[91],"negative-control,":[93],"sequence":[95],"decreased":[96],"IL-1\u03b1.":[100,127],"Rate":[101],"about":[106],"15%.":[107],"CONCLUSION:":[108],"RNAi":[109],"technology":[110],"produces":[111],"specific":[112],"interference":[113],"mouse":[116],"spleen":[117],"original":[120],"inhibits":[123],"excretion":[125]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}