{"id":"https://openalex.org/W2390435104","doi":null,"title":"Characterization of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Saccharomyces cerevisiae","display_name":"Characterization of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor from Saccharomyces cerevisiae","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2390435104","mag":"2390435104"},"language":"en","primary_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/112847","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/112847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T200403662.pdf","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/112847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100666849","display_name":"Jaeho Kim","orcid":"https://orcid.org/0000-0003-3770-2359","observed_orcids":["https://orcid.org/0000-0003-3770-2359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaeho Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3770-2359","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dae\u2010Hyoung Lee","orcid":"https://orcid.org/0000-0001-6194-7474","observed_orcids":["https://orcid.org/0000-0001-6194-7474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dae\u2010Hyoung Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6194-7474","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087308703","display_name":"Seoung-Chan Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seoung-Chan Jeong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014242811","display_name":"Kun-Sub Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun-Sub Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100649357","display_name":"Jong\u2010Soo Lee","orcid":"https://orcid.org/0000-0001-5119-0711","observed_orcids":["https://orcid.org/0000-0001-5119-0711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong\u2010Soo Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5119-0711","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7733,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.76491669,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"6","first_page":"1318","last_page":"1323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antihypertensive-peptides","display_name":"antihypertensive peptides","score":0.8140000104904175},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9879999756813049},{"id":"https://openalex.org/keywords/peptide-purification","display_name":"peptide purification","score":0.6959999799728394},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6850000023841858},{"id":"https://openalex.org/keywords/decapeptide","display_name":"decapeptide","score":0.7360000014305115},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.4259999990463257},{"id":"https://openalex.org/keywords/pepsin-treatment","display_name":"pepsin treatment","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7312486171722412},{"id":"https://openalex.org/C163994747","wikidata":"https://www.wikidata.org/wiki/Q2916358","display_name":"Sephadex","level":3,"score":0.7060736417770386},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.6592475175857544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6548112630844116},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6059088110923767},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.5977562665939331},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5942838788032532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5619279146194458},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.5500357747077942},{"id":"https://openalex.org/C2777880890","wikidata":"https://www.wikidata.org/wiki/Q412208","display_name":"Lisinopril","level":4,"score":0.5275667905807495},{"id":"https://openalex.org/C50817676","wikidata":"https://www.wikidata.org/wiki/Q7880534","display_name":"Ultrafiltration (renal)","level":2,"score":0.5099114179611206},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.45868420600891113},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.42860424518585205},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.419522762298584},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3331310749053955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17607063055038452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09721750020980835},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/112847","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/112847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T200403662.pdf","raw_type":"Article"},{"id":"mag:2390435104","doi":null,"is_oa":false,"landing_page_url":"https://agris.fao.org/agris-search/search.do?recordID=KR2005012174","pdf_url":null,"source":{"id":"https://openalex.org/S70307536","display_name":"Journal of Microbiology and Biotechnology","issn_l":"1017-7825","issn":["1017-7825","1738-8872"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","kci-registered","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Microbiology and Biotechnology","raw_type":null},{"id":"mag:3045123775","doi":null,"is_oa":false,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/112847/1/T200403662.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/112847","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/112847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"T200403662.pdf","raw_type":"Article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2317880836","https://openalex.org/W2331674164","https://openalex.org/W7097446365","https://openalex.org/W2351710532","https://openalex.org/W1986492268","https://openalex.org/W2963226356","https://openalex.org/W2741236870","https://openalex.org/W2096500427","https://openalex.org/W2949044831","https://openalex.org/W1988218309"],"abstract_inverted_index":{"This":[0],"study":[1],"describes":[2],"the":[3,23,52,58],"purification":[4,59],"and":[5,38,70,82,104,117],"characterization":[6],"of":[7,22,34,51,60,79,132],"a":[8,91,120,130],"novel":[9,92],"antihypertensive":[10,122],"angiotensin":[11],"I-converting":[12],"enzyme":[13],"(ACE)":[14],"inhibitory":[15,41,62,101],"peptide":[16,89,102],"from":[17,26,31],"Saccharomyces":[18,27],"cerevisiae.":[19],"Maximal":[20],"production":[21],"ACE":[24,40,61,100,116],"inhibitor":[25,113],"cerevisiae":[28],"was":[29,43,85,90,109],"obtained":[30],"24":[32],"h":[33],"cultivation":[35],"at":[36,129],"30\uc9f8C":[37],"its":[39,105],"activity":[42],"increased":[44],"by":[45],"about":[46],"1.5":[47],"times":[48],"after":[49],"treatment":[50],"cell-free":[53],"extract":[54],"with":[55,64,76],"pepsin.":[56],"After":[57],"peptides":[63],"ultrafiltration,":[65],"Sephadex":[66],"G-25":[67],"column":[68],"chromatography,":[69],"reverse-phase":[71],"HPLC,":[72],"an":[73,77],"active":[74],"fraction":[75],"IC50":[78],"0.07":[80],"mg":[81],"3.5%":[83],"yield":[84],"obtained.":[86],"The":[87,111],"purified":[88,112],"decapeptide,":[93],"showing":[94],"very":[95],"low":[96],"similarity":[97],"to":[98],"other":[99],"sequences,":[103],"amino":[106],"acid":[107],"sequence":[108],"Tyr-Asp-Gly-Gly-Val-Phe-Arg-Val-Tyr-Thr.":[110],"competitively":[114],"inhibited":[115],"also":[118],"showed":[119],"clear":[121],"effect":[123],"in":[124],"spontaneously":[125],"hypertensive":[126],"rats":[127],"(SHR)":[128],"dosage":[131],"1":[133],"mg/kg":[134],"body":[135],"weight":[136]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}