{"id":"https://openalex.org/W2390401065","doi":null,"title":"Transplantation of Neural Precursor Cells into the Focal Cerebral Cortex Ischemic Boundary Zones of Newborn Rats","display_name":"Transplantation of Neural Precursor Cells into the Focal Cerebral Cortex Ischemic Boundary Zones of Newborn Rats","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2390401065","mag":"2390401065"},"language":"en","primary_location":{"id":"mag:2390401065","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HJZY200304001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879783","display_name":"Journal of Naval General Hospital","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Naval General Hospital of PLA","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ying Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.229265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.7870000004768372},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.7519999742507935},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.8309999704360962},{"id":"https://openalex.org/keywords/brdu-labeling","display_name":"BrdU labeling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/graft-incorporation","display_name":"graft integration","score":0.7409999966621399},{"id":"https://openalex.org/keywords/granule-cell-layer","display_name":"granular layer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neonatal-brain-injury","display_name":"neonatal brain injury","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C124964019","wikidata":"https://www.wikidata.org/wiki/Q11616062","display_name":"Precursor cell","level":3,"score":0.8160642385482788},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.7628068327903748},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6310928463935852},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.6241297721862793},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5711264610290527},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4982936382293701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4968562424182892},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4489629566669464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42730244994163513},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.41970160603523254},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3053175210952759},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2637164294719696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2611478567123413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.260639488697052},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15716829895973206},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13020318746566772}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2390401065","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HJZY200304001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879783","display_name":"Journal of Naval General Hospital","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Naval General Hospital of PLA","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2360961016","https://openalex.org/W2381249877","https://openalex.org/W1996222694","https://openalex.org/W2087200027","https://openalex.org/W2363252818","https://openalex.org/W2139525542","https://openalex.org/W1985483152","https://openalex.org/W2073811034","https://openalex.org/W2363276073","https://openalex.org/W2371682419"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,6,42,52,60,74,97,103,112,117,121,127,130,141,152,162,168,176,180,191,197,205,221,239],"fate":[4],"of":[5,18,62,102,126,179,214,217,230,244],"neural":[7,43,53,67,75,88,222,231],"precursor":[8,44,54,68,76,89,223,232],"cells":[9,55,69,90,198,224,233],"transplanted":[10,95],"into":[11,51,96,204],"focal":[12],"cerebral":[13,98,113,132,154,165,182,215,240],"cortex":[14,133,155,166,183,208,241],"ischemic":[15,99,212,242],"boundary":[16,100],"zone":[17],"newborn":[19,104],"rats.":[20],"Methods":[21],"A":[22],"free-serum":[23],"medium":[24],"D/F12":[25],"(1:1)":[26],"containing":[27],"basic":[28],"fibroblast":[29],"growth":[30,35],"factor":[31,36],"(bFGF)":[32],"and":[33,47,83,124,184],"epidermal":[34],"(EGF)":[37],"was":[38,49,194],"used":[39,236],"to":[40,56,115,225,237],"obtain":[41],"cell":[45,77],"spheres":[46],"BrdU":[48,93,149,201],"incorporated":[50],"mark":[57,78],"them":[58],"during":[59],"period":[61],"culturing":[63],"in":[64,129,151,161,187],"vitro.":[65],"The":[66,87,145,171,211],"were":[70,94,108,134],"identified":[71],"by":[72,110],"detecting":[73],"nestin":[79],"with":[80,92,140,148,200],"immuno-enzyme":[81],"techniques":[82],"inducing":[84],"differentiation":[85],"tests.":[86],"marked":[91,147,199],"zones":[101],"rat":[105],"models":[106],"which":[107],"made":[109],"removing":[111],"menings":[114],"stop":[116],"blood":[118],"supply":[119],"for":[120],"neop-allium.":[122],"Living":[123],"incorporating":[125],"grafts":[128,146],"host":[131,206],"detected":[135],"at":[136],"defined":[137],"time":[138],"points":[139],"immuno-histochemical":[142],"technique.":[143],"Results":[144],"living":[150],"in-juried":[153],"are":[156],"significantly":[157],"more":[158],"than":[159],"that":[160,196,228],"opposite":[163],"intact":[164],"as":[167],"experiment":[169],"controls.":[170],"grafs":[172],"mainly":[173],"focused":[174],"on":[175],"granular":[177],"layer":[178],"injuried":[181],"not":[185],"found":[186],"remote":[188],"sites":[189],"from":[190],"lesion,":[192],"It":[193],"watched":[195],"well":[202],"integrated":[203],"cerbral":[207],"tissues.":[209],"Conclusion":[210],"lesion":[213,243],"neocontex":[216],"rats":[218],"can":[219,234],"activate":[220],"develop,":[226],"suggesting":[227],"transplantation":[229],"be":[235],"therapy":[238],"newborns.":[245]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}