{"id":"https://openalex.org/W2390323263","doi":null,"title":"Hydrogen sulfide alleviates myocardial fibrosis by inhibiting transforming growth factor-\u03b2/membrane-type-3 matrix metalloproteinase signaling pathway in diabetic rats","display_name":"Hydrogen sulfide alleviates myocardial fibrosis by inhibiting transforming growth factor-\u03b2/membrane-type-3 matrix metalloproteinase signaling pathway in diabetic rats","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2390323263","mag":"2390323263"},"language":"en","primary_location":{"id":"mag:2390323263","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-ZGGZ201508018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764628170","display_name":"Chinese Journal of Hypertension","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4360969488","host_organization_name":"First Affiliated Hospital of Fujian Medical University","host_organization_lineage":["https://openalex.org/P4360969488"],"host_organization_lineage_names":["First Affiliated Hospital of Fujian Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Hypertension","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044707957","display_name":"Ou Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ou Zeng","raw_affiliation_strings":["Department of Cardiology,The First Affiliated Hospital of South China University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology,The First Affiliated Hospital of South China University","institution_ids":["https://openalex.org/I4210143187"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044707957"],"corresponding_institution_ids":["https://openalex.org/I4210143187"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23707224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":1.0},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8080000281333923},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5740000009536743},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7889999747276306},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/sodium-hydrosulfide","display_name":"sodium hydrosulfide","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2780519940","wikidata":"https://www.wikidata.org/wiki/Q414203","display_name":"Sodium hydrosulfide","level":4,"score":0.7793244123458862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.710787296295166},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.7061779499053955},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7030523419380188},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6898223161697388},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6603843569755554},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5568735599517822},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5419008135795593},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5109976530075073},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.5081171989440918},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4869914948940277},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.45756796002388},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.45078200101852417},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4477088451385498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4466545283794403},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4151155650615692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3090999126434326},{"id":"https://openalex.org/C2780564542","wikidata":"https://www.wikidata.org/wiki/Q170591","display_name":"Hydrogen sulfide","level":3,"score":0.14886412024497986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1235453188419342},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2390323263","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-ZGGZ201508018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764628170","display_name":"Chinese Journal of Hypertension","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4360969488","host_organization_name":"First Affiliated Hospital of Fujian Medical University","host_organization_lineage":["https://openalex.org/P4360969488"],"host_organization_lineage_names":["First Affiliated Hospital of Fujian Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Hypertension","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1641656451","https://openalex.org/W2359608070","https://openalex.org/W2393985052","https://openalex.org/W2392579401","https://openalex.org/W2943025830","https://openalex.org/W2617840473","https://openalex.org/W2786099180","https://openalex.org/W2951428377","https://openalex.org/W278532787","https://openalex.org/W2700511465"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3],"effects":[4],"of":[5,51,98,110,120,125,148,167,201],"hydrogen":[6],"sulfide(H2S)on":[7],"myocardial":[8,189],"fibrosis":[9,190],"and":[10,37,77,90],"transforming":[11],"growth":[12],"factor-\u03b2(TGF-\u03b2)/membrane-type-3":[13],"matrix":[14],"metalloproteinase(MT3-MMP)signaling":[15],"pathway":[16],"in":[17,54,72,87,143,159,178,191],"diabetic":[18,192],"rats.":[19],"Methods":[20],"Fifty-two":[21],"adult":[22],"male":[23],"SD":[24],"rats":[25,45,71,86],"were":[26,46,67,81,93,129,151,156,171],"randomly":[27],"divided":[28],"into":[29],"four":[30],"groups(n=13):control":[31],"group,diabetes":[32],"group,H2":[33],"S":[34,40,74,79,180,187],"treatment":[35,41,75,181],"group":[36,76,80,89,92],"normal":[38,99],"H2":[39,73,78,179,186],"group(H2S":[42],"group).":[43],"Diabetic":[44],"induced":[47],"by":[48,101,114,131],"intraperitoneal":[49,102],"injection":[50],"streptozotocin(STZ).Blood":[52],"glucose":[53],"tail":[55],"venous":[56],"blood":[57,64],"was":[58,112,140],"detected":[59],"72":[60],"hafter":[61],"injection.Rats":[62],"with":[63,83,95,136,162],"glucose16.7":[65],"mmol/L":[66],"considered":[68],"diabetes.":[69],"Then":[70],"injected":[82,94],"sodium":[84],"hydrosulfide[100\u03bcmol/(kg\u00b7d)]and":[85],"control":[88,137],"diabetes":[91,144,160,163],"equal":[96],"volume":[97],"saline":[100],"administration":[103],"every":[104],"day.":[105],"After":[106],"8weeks,the":[107],"pathological":[108],"morphology":[109],"myocardium":[111],"analyzed":[113,130],"Van":[115],"Gieson(VG)staining.":[116],"The":[117],"expression":[118,146,165],"levels":[119,147,166],"Collagen\u2160,Collagen":[121,168],"\u2162,matrix":[122],"metalloproteinase(MMP)1,MMP-2,tissue":[123],"inhibitor":[124],"metalloproteinase":[126],"2(TIMP-2)and":[127],"TGF-\u03b2/MT3-MMP":[128],"Western":[132],"blotting.":[133],"Results":[134],"Compared":[135],"group,collagen":[138],"accumulation":[139],"markedly":[141],"enhanced":[142],"group.The":[145],"Collagen\u2160,Collagen\u2162,TIMP-2,TGF-\u03b2,and":[149],"MT3-MMP":[150,170],"significantly":[152,157,172,176],"increased,while":[153],"MMP-1and":[154,174],"MMP-2":[155],"decreased":[158],"group(P0.01).Compared":[161],"group,the":[164],"\u2162,TIMP-2,TGF-\u03b2and":[169],"decreased,while":[173],"MMP-2were":[175],"increased":[177],"group(P0.01":[182],"or":[183],"P0.05).":[184],"Conclusion":[185],"attenuates":[188],"rats,and":[193],"its":[194],"mechanism":[195],"may":[196],"be":[197],"related":[198],"to":[199],"down-regulation":[200],"TGF-\u03b2/MT3-MMP.":[202]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}