{"id":"https://openalex.org/W2390155097","doi":null,"title":"[Protective effect of total flavonoids of herba epimedii on testis degeneration in diabetic mice].","display_name":"[Protective effect of total flavonoids of herba epimedii on testis degeneration in diabetic mice].","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2390155097","mag":"2390155097","pmid":"https://pubmed.ncbi.nlm.nih.gov/24386819"},"language":"zh","primary_location":{"id":"pmid:24386819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24386819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100682847","display_name":"Jie Shi","orcid":"https://orcid.org/0000-0001-6072-7031","observed_orcids":["https://orcid.org/0000-0001-6072-7031"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Shi","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008640954","display_name":"Yan Fang GONG","orcid":"https://orcid.org/0000-0002-3562-971X","observed_orcids":["https://orcid.org/0000-0002-3562-971X"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Gong","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057821775","display_name":"Gao-Yu Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110640572","display_name":"Guiyang College of Traditional Chinese Medicine","ror":"https://ror.org/02bb8n686","country_code":"CN","type":"education","lineage":["https://openalex.org/I110640572"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gao-Yu Xie","raw_affiliation_strings":["Basic Medical College, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Medical College, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China","institution_ids":["https://openalex.org/I110640572"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao-Ran Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao-Ran Liu","raw_affiliation_strings":["Pharmacology Department, College of Chemistry and Cheimical Engineering, Hu'nan University, Changsha 410082, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Department, College of Chemistry and Cheimical Engineering, Hu'nan University, Changsha 410082, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024229666","display_name":"Min-You Qi","orcid":"https://orcid.org/0000-0003-3203-4080","observed_orcids":["https://orcid.org/0000-0003-3203-4080","https://orcid.org/0009-0007-8459-3315"]},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min-You Qi","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China","institution_ids":["https://openalex.org/I55712492"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4225,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.56835589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"29","issue":"5","first_page":"428","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.41040000319480896,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epimedium","display_name":"Epimedium","score":0.7549999952316284},{"id":"https://openalex.org/keywords/testicular-degeneration","display_name":"testicular degeneration","score":0.8740000128746033},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7590000033378601},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":1.0},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8420000076293945},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8679999709129333},{"id":"https://openalex.org/keywords/seminiferous-tubules","display_name":"seminiferous tubules","score":0.8140000104904175},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/testicular-fibrosis","display_name":"testicular fibrosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2781005915","wikidata":"https://www.wikidata.org/wiki/Q417701","display_name":"Alloxan","level":3,"score":0.7280195951461792},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.710895299911499},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6723951101303101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6622477769851685},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6215875744819641},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5915085077285767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5317304134368896},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.49683430790901184},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4946148097515106},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4493850767612457},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.433554470539093},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.38618502020835876},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.33751291036605835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30419284105300903}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24386819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24386819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"Journal Article"},{"id":"mag:2390155097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24386819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2988270271","https://openalex.org/W2359143368","https://openalex.org/W2385067913","https://openalex.org/W4417399537","https://openalex.org/W2600513271","https://openalex.org/W2376804007","https://openalex.org/W1848036686","https://openalex.org/W7125828775","https://openalex.org/W2356880906","https://openalex.org/W2391038686"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,8,81,85,97,116,129,138,155,173,196,204,210],"protective":[4],"effects":[5],"and":[6,56,72,108,128,143,166,208],"investigate":[7],"possible":[9],"mechanism":[10],"of":[11,14,33,69,89,99,118,131,140,151,157,162,175,198,212],"total":[12],"flavonoids":[13],"herba":[15],"epimedii":[16],"(TFE)":[17],"on":[18],"diabetic":[19],"testopathy":[20],"in":[21,39,80,133,147,170,179,187],"mice.":[22,40],"METHODS:":[23],"Diabetic":[24],"animal":[25],"model":[26,54,148,180],"was":[27,101,112],"produced":[28],"by":[29,106],"a":[30],"single":[31],"injection":[32],"alloxan":[34],"(":[35],"70":[36],"mg/kg,":[37,60],"i.v.)":[38],"The":[41,67],"mice":[42,201],"were":[43,75,177,184],"randomly":[44],"divided":[45],"into":[46],"3":[47],"groups":[48],"(n":[49],"=":[50],"10):":[51],"control":[52,125],"group,":[53,126],"group":[55,58,189],"TFE":[57,188,194],"(100":[59],"p.o.),":[61],"administrated":[62],"for":[63],"8":[64],"weeks":[65],"continuously.":[66],"level":[68,117],"serum":[70,141],"testosterone":[71,142,205],"blood":[73],"glucose":[74,127],"measured":[76],"after":[77],"24":[78],"hours":[79],"last":[82],"administration.":[83],"Detect":[84],"specific":[86],"biochemical":[87],"indicators":[88],"testis:":[90],"superoxide":[91],"dismutase":[92],"(SOD),":[93],"malondialdehyde":[94],"(MDA).":[95],"Meanwhile,":[96],"morphology":[98],"testis":[100,199],"observed":[102],"under":[103],"light":[104],"microscope":[105],"HE":[107],"MASSION":[109],"dyeing.":[110],"Immunohistochemistry":[111],"employed":[113],"to":[114],"detect":[115],"matrix":[119],"metalloprotein":[120],"(MMP)9.":[121],"RESULTS:":[122],"Compared":[123],"with":[124],"content":[130],"MDA":[132],"testicular":[134,171],"tissues":[135],"increased":[136],"while":[137],"levels":[139],"SOD":[144],"decreased":[145,165,178],"remarkably":[146],"group.":[149,181],"Detection":[150],"pathology":[152],"showed":[153],"that":[154],"diameters":[156],"seminiferous":[158],"tubules,":[159],"various":[160],"grades":[161],"spermatogenic":[163],"cell":[164],"collagen":[167],"fibrosis":[168],"hyperplasia":[169],"tissues,":[172],"expression":[174,211],"(MMP9)":[176],"These":[182],"alterations":[183,197],"significantly":[185],"improved":[186],"(P":[190],"<":[191],"0.01).":[192],"CONCLUSION:":[193],"ameliorated":[195],"inalloxan-induced":[200],"through":[202],"promoting":[203],"release,":[206],"anti-oxidation":[207],"improving":[209],"MMP9.":[213]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
