{"id":"https://openalex.org/W2390030148","doi":null,"title":"Progress in Synthesis of Aprepitant","display_name":"Progress in Synthesis of Aprepitant","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2390030148","mag":"2390030148"},"language":"en","primary_location":{"id":"mag:2390030148","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SDPK201501021.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764437707","display_name":"Shipin yu yaopin","issn_l":"1672-979X","issn":["1672-979X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4364293134","host_organization_name":"Shandong Food Company","host_organization_lineage":["https://openalex.org/P4364293134"],"host_organization_lineage_names":["Shandong Food Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shipin yu yaopin","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112128690","display_name":"Ding Ju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34949971","display_name":"University of Jinan","ror":"https://ror.org/02mjz6f26","country_code":"CN","type":"education","lineage":["https://openalex.org/I34949971"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ding Ju","raw_affiliation_strings":["Institute of Materia Medica, Shandong Academy of Medical Sciences, University of Jinan-School of Medicine and Life Sciences, Shandong Academy of Medical Sciences,Key Lab"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Medica, Shandong Academy of Medical Sciences, University of Jinan-School of Medicine and Life Sciences, Shandong Academy of Medical Sciences,Key Lab","institution_ids":["https://openalex.org/I34949971","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112128690"],"corresponding_institution_ids":["https://openalex.org/I34949971","https://openalex.org/I4210163399"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24848749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.2678000032901764,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.2678000032901764,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.1444000005722046,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.11630000174045563,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aprepitant","display_name":"aprepitant","score":1.0},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antiemetics","display_name":"antiemetics","score":0.6480000019073486},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea","display_name":"chemotherapy-induced nausea","score":0.6370000243186951},{"id":"https://openalex.org/keywords/synthetic-intermediates","display_name":"synthetic intermediates","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2780574406","wikidata":"https://www.wikidata.org/wiki/Q621834","display_name":"Aprepitant","level":4,"score":0.9988329410552979},{"id":"https://openalex.org/C202871150","wikidata":"https://www.wikidata.org/wiki/Q12744608","display_name":"NK1 receptor antagonist","level":5,"score":0.5974218845367432},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5716792345046997},{"id":"https://openalex.org/C137130169","wikidata":"https://www.wikidata.org/wiki/Q15316325","display_name":"Tachykinin receptor 1","level":5,"score":0.5070712566375732},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4702932834625244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38261958956718445},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22138503193855286},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2119738757610321},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.14656579494476318},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.10618379712104797},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.06670153141021729}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2390030148","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SDPK201501021.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764437707","display_name":"Shipin yu yaopin","issn_l":"1672-979X","issn":["1672-979X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4364293134","host_organization_name":"Shandong Food Company","host_organization_lineage":["https://openalex.org/P4364293134"],"host_organization_lineage_names":["Shandong Food Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shipin yu yaopin","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2913767568","https://openalex.org/W1953206224","https://openalex.org/W2027434217","https://openalex.org/W2312369223","https://openalex.org/W2949546688","https://openalex.org/W1927779379","https://openalex.org/W2420147432","https://openalex.org/W1987583125","https://openalex.org/W2889253017","https://openalex.org/W2027199330"],"abstract_inverted_index":{"As":[0],"a":[1],"neurokinin":[2],"1(NK-1)":[3],"receptor":[4],"blocking":[5],"pharmacon,":[6],"aprepitant":[7],"is":[8],"considered":[9],"to":[10],"be":[11],"one":[12],"of":[13,28,35,40],"the":[14,24,31,36],"most":[15,37],"effective":[16],"anti-nausea":[17],"drugs":[18],"on":[19],"chemotherapy.":[20],"This":[21],"paper":[22],"reviews":[23],"progress":[25],"in":[26],"synthesis":[27],"aprepitant,":[29],"especially":[30],"different":[32],"synthetic":[33],"methods":[34],"important":[38],"intermediate":[39],"aprepitant.":[41]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}