{"id":"https://openalex.org/W2389993230","doi":null,"title":"Musculoskeletal Adverse Events Associated with Simvastatin Drug Interactions and Physician Response to Pharmacist Interventions","display_name":"Musculoskeletal Adverse Events Associated with Simvastatin Drug Interactions and Physician Response to Pharmacist Interventions","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2389993230","mag":"2389993230"},"language":"th","primary_location":{"id":"pmh:oai:he01.tci-thaijo.org:article/48603","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/view/48603","pdf_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/download/48603/40386","source":{"id":"https://openalex.org/S7407065949","display_name":"Isan Journal of Pharmaceutical Sciences, IJPS (Isan J Pharm Sci)","issn_l":"1905-0852","issn":["1905-0852"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1905-0852","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/download/48603/40386","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003528783","display_name":"Methira Siriangkhawut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Methira Siriangkhawut","raw_affiliation_strings":["Faculty of Pharmaceutical Science, Khon Kaen University, 40002"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Science, Khon Kaen University, 40002","institution_ids":["https://openalex.org/I179193067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003528783"],"corresponding_institution_ids":["https://openalex.org/I179193067"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"5","first_page":"190","last_page":"201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.4287000000476837,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.4287000000476837,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.2117999941110611,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/statin-drug-interactions","display_name":"statin-drug interactions","score":0.8949999809265137},{"id":"https://openalex.org/keywords/myopathy","display_name":"myopathy","score":0.800000011920929},{"id":"https://openalex.org/keywords/musculoskeletal-adverse-events","display_name":"musculoskeletal adverse events","score":0.8870000243186951},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/inflammatory-myopathies","display_name":"myositis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/creatine-kinase-elevation","display_name":"creatine kinase elevation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pharmacist-intervention","display_name":"pharmacist intervention","score":0.7319999933242798},{"id":"https://openalex.org/keywords/physician-responses","display_name":"physician responses","score":0.7260000109672546},{"id":"https://openalex.org/keywords/gemfibrozil","display_name":"gemfibrozil","score":0.9430000185966492},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":1.0},{"id":"https://openalex.org/keywords/drug-interaction-probability-scale","display_name":"Drug Interaction Probability Scale","score":0.8980000019073486},{"id":"https://openalex.org/keywords/thai-patients","display_name":"Thai patients","score":0.7149999737739563},{"id":"https://openalex.org/keywords/prescription-changes","display_name":"prescription changes","score":0.5230000019073486},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.4569999873638153},{"id":"https://openalex.org/keywords/thailand","display_name":"Thailand","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9205127954483032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8628820180892944},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.8582406044006348},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6908353567123413},{"id":"https://openalex.org/C2777300911","wikidata":"https://www.wikidata.org/wiki/Q692536","display_name":"Myopathy","level":2,"score":0.5403227806091309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5229652523994446},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.4853712320327759},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4367060363292694},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.4102257490158081},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.38881993293762207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3180341124534607}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:he01.tci-thaijo.org:article/48603","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/view/48603","pdf_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/download/48603/40386","source":{"id":"https://openalex.org/S7407065949","display_name":"Isan Journal of Pharmaceutical Sciences, IJPS (Isan J Pharm Sci)","issn_l":"1905-0852","issn":["1905-0852"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1905-0852","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2389993230","doi":null,"is_oa":false,"landing_page_url":"https://www.tci-thaijo.org/index.php/IJPS/article/view/48603","pdf_url":null,"source":{"id":"https://openalex.org/S4306514446","display_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e2d\u0e35\u0e2a\u0e32\u0e19  (Isan  Journal of Pharmaceutical Sciences, IJPS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e2d\u0e35\u0e2a\u0e32\u0e19 (Isan Journal of Pharmaceutical Sciences, IJPS)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:he01.tci-thaijo.org:article/48603","doi":null,"is_oa":true,"landing_page_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/view/48603","pdf_url":"https://he01.tci-thaijo.org/index.php/IJPS/article/download/48603/40386","source":{"id":"https://openalex.org/S7407065949","display_name":"Isan Journal of Pharmaceutical Sciences, IJPS (Isan J Pharm Sci)","issn_l":"1905-0852","issn":["1905-0852"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1905-0852","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2389993230.pdf","grobid_xml":"https://content.openalex.org/works/W2389993230.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W99811786","https://openalex.org/W1560686237","https://openalex.org/W1565314983","https://openalex.org/W1976358806","https://openalex.org/W1976388282","https://openalex.org/W1982590538","https://openalex.org/W1985258130","https://openalex.org/W1990763296","https://openalex.org/W2001215144","https://openalex.org/W2010033213","https://openalex.org/W2018126221","https://openalex.org/W2019071303","https://openalex.org/W2029268880","https://openalex.org/W2040982838","https://openalex.org/W2043384854","https://openalex.org/W2047207059","https://openalex.org/W2051160165","https://openalex.org/W2051922899","https://openalex.org/W2067434784","https://openalex.org/W2069069910","https://openalex.org/W2120093163","https://openalex.org/W2143931228","https://openalex.org/W2152558468","https://openalex.org/W2164112965","https://openalex.org/W2318373131","https://openalex.org/W2321631825"],"related_works":["https://openalex.org/W7217099877","https://openalex.org/W2562648645","https://openalex.org/W2029268880","https://openalex.org/W2565357590","https://openalex.org/W4313457360","https://openalex.org/W2802575535","https://openalex.org/W2175362156","https://openalex.org/W2413886359","https://openalex.org/W2796107074","https://openalex.org/W2090805785"],"abstract_inverted_index":{"Introduction:":[0],"Myopathy":[1],"is":[2,17,31,49,65],"the":[3,20,38,58,74,135,139,146,173,243,249,279],"major":[4],"adverse":[5,27,42,62,116,136,177,190,257],"events":[6,43,117,137,178,191,258],"which":[7,64],"can":[8,281],"be":[9,282],"found":[10,158,165,197,205,263],"with":[11,25,45,67,193,222,227,259],"statins":[12],"use.":[13],"The":[14,114,131,153,218],"statin-drug":[15],"interaction":[16,93],"one":[18],"of":[19,40,60,270,292],"important":[21],"risk":[22],"factor":[23],"associated":[24,44,66,192,221,273],"musculoskeletal":[26,41,61,115],"events.":[28],"Although":[29],"simvastatin":[30,46,228,260],"mostly":[32,225],"prescribed":[33,226],"in":[34,159,198,253,264],"Thailand,":[35],"studies":[36],"investigating":[37],"prevalence":[39,59],"drug":[47],"interactions":[48,142,156,195],"still":[50],"limited.":[51],"Objective:":[52],"This":[53,96],"study":[54,98],"aims":[55],"to":[56,77,81,235,238,289],"investigate":[57],"effect":[63],"simvastatin-drug":[68,83,92,141,155,194,241,274,294],"interactions.":[69,275,295],"In":[70],"addition,":[71],"we":[72,164,204],"evaluated":[73,119],"physician":[75],"response":[76],"pharmacist":[78,236],"intervention":[79],"regarding":[80],"potential":[82,91,140,154,293],"interaction.":[84],"Methods:":[85],"Outpatients":[86],"who":[87],"had":[88,169,210],"prescriptions":[89,250],"containing":[90],"were":[94,118,157,196,229,251,262],"recruited.":[95],"cross-sectional":[97],"was":[99,143,172,246,272],"conducted":[100],"between":[101,134],"October":[102],"1,":[103],"2013":[104],"and":[105,125,138,186,208,215,232,248,267],"February":[106],"28,":[107],"2014":[108],"at":[109],"Piboonmungsaharn":[110],"Hospital,":[111],"Ubonratchathanee":[112],"Province.":[113],"by":[120,181,284],"using":[121,145],"symptom":[122],"checklist":[123],"questionnaires":[124],"measuring":[126],"plasma":[127],"creatinine":[128],"kinase":[129],"(CK).":[130],"causal":[132],"relationship":[133],"assessed":[144],"Drug":[147],"Interaction":[148],"Probability":[149],"Scale":[150],"(DIPS).":[151],"Results:":[152],"49":[160],"patients.":[161],"Of":[162,202],"these,":[163,203],"31":[166],"patients":[167,200],"(63.3%)":[168],"myopathy.":[170],"Myalgia":[171],"most":[174],"frequently":[175],"identified":[176],"(58.1%),":[179],"followed":[180],"asymptomatic":[182,211],"raising":[183,212],"CK":[184],"(25.8%),":[185],"myositis":[187],"(16.1%).":[188],"Musculoskeletal":[189,256],"16":[199],"(51.6%).":[201],"50.0%,":[206],"31.3%":[207],"18.8%":[209],"CK,":[213],"myalgia,":[214],"myositis,":[216],"respectively.":[217],"precipitant":[219],"drugs":[220],"myopathy":[223],"that":[224,278],"gemfibrozil,":[230],"colchicine":[231],"amlodipine.":[233],"According":[234],"interventions":[237],"physicians":[239],"about":[240],"interactions,":[242],"acceptance":[244],"rate":[245],"83.7%":[247],"changed":[252],"49.0%.":[254],"Conclusion:":[255],"use":[261],"Thai":[265],"patients,":[266],"approximately":[268],"half":[269],"them":[271],"Data":[276],"suggested":[277],"systems":[280],"utilized":[283],"healthcare":[285],"professionals":[286],"are":[287],"needed":[288],"increase":[290],"awareness":[291]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}