{"id":"https://openalex.org/W2389966934","doi":null,"title":"Establishment of mouse model highly expressing Bcl-2 protein","display_name":"Establishment of mouse model highly expressing Bcl-2 protein","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2389966934","mag":"2389966934"},"language":"en","primary_location":{"id":"mag:2389966934","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-TJIY201203004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764472295","display_name":"Journal of Tongji University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Tongji University","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031697521","display_name":"Yanfei Zhang","orcid":"https://orcid.org/0000-0003-2270-8483","observed_orcids":["https://orcid.org/0000-0003-2270-8483"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanfei Zhang","raw_affiliation_strings":["~1 JIANG Jian-xin~"],"raw_orcid":"https://orcid.org/0000-0003-2270-8483","affiliations":[{"raw_affiliation_string":"~1 JIANG Jian-xin~","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100347150","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-7852-386X","observed_orcids":["https://orcid.org/0000-0002-7852-386X","https://orcid.org/0000-0001-8941-0484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["~1,ZHANG Kui-ming~1,FAN Hui-min~2,SUN Zhi-yang~1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"~1,ZHANG Kui-ming~1,FAN Hui-min~2,SUN Zhi-yang~1","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24126679,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.3107999861240387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8610000014305115},{"id":"https://openalex.org/keywords/founder-mice","display_name":"founder mice","score":0.6460000276565552},{"id":"https://openalex.org/keywords/backcrossing","display_name":"backcrossing","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.8271416425704956},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6962183713912964},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.68267822265625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6757831573486328},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6288373470306396},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.59380042552948},{"id":"https://openalex.org/C72472911","wikidata":"https://www.wikidata.org/wiki/Q2004691","display_name":"Backcrossing","level":3,"score":0.5750064253807068},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.540446400642395},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5249788165092468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5237888097763062},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4370262622833252},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3078150153160095},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22535669803619385}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2389966934","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-TJIY201203004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764472295","display_name":"Journal of Tongji University","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319982","host_organization_name":"Science Press","host_organization_lineage":["https://openalex.org/P4310319982"],"host_organization_lineage_names":["Science Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Tongji University","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2372888361","https://openalex.org/W2365795027","https://openalex.org/W995901548","https://openalex.org/W2365806845","https://openalex.org/W3184649120","https://openalex.org/W3143187016","https://openalex.org/W2373928503","https://openalex.org/W2373562819","https://openalex.org/W2356432876","https://openalex.org/W2359344294"],"abstract_inverted_index":{"Objective":[0],"To":[1],"establish":[2],"a":[3],"mouse":[4,112],"model":[5,113],"highly":[6,106,114],"expressing":[7,67,107,115],"Bcl-2":[8,13,68,116],"protein":[9,117],"for":[10],"study":[11],"of":[12,30,43,94],"function":[14],"in":[15,40,122],"vivo.Methods":[16],"The":[17,111],"plasmid":[18],"containing":[19],"human":[20],"bcl-2":[21,48],"gene":[22],"was":[23,25],"constructed,which":[24],"transferred":[26],"to":[27],"fertilized":[28,36],"eggs":[29,37],"C57BL/6J\u00d7CBA":[31,58],"hybrid":[32,59],"mice":[33,50,56,60,66,80,105],"by":[34,71,99],"microinjection;the":[35],"were":[38,51,61,69,81,84,109],"implanted":[39],"the":[41,52,64],"uterus":[42],"falsely":[44],"pregnant":[45],"female":[46],"mice.The":[47],"gene-carrying":[49],"Founder":[53,55,79],"mice,the":[54],"and":[57,75,89,97,101],"continuously":[62],"backcrossed,and":[63],"transgenic":[65,104],"obtained":[70],"screening":[72,98],"with":[73],"PCR":[74,100],"Western":[76,102],"blotting.Results":[77],"Five":[78],"obtained;the":[82],"strains":[83],"successfully":[85,120],"established":[86,121],"from":[87],"#6":[88],"#14":[90],"mice.After":[91],"7":[92],"generations":[93],"backcross":[95],"breeding":[96],"blot,42":[103],"bcl-2PCR":[108],"obtained.Conclusion":[110],"has":[118],"been":[119],"this":[123],"study.":[124]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
