{"id":"https://openalex.org/W2389628478","doi":null,"title":"The changes of serum matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 in patients with obstructive sleep apnea hypopnea syndrome and obstructive sleep apnea-hypopnea associated hypertension","display_name":"The changes of serum matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 in patients with obstructive sleep apnea hypopnea syndrome and obstructive sleep apnea-hypopnea associated hypertension","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2389628478","mag":"2389628478"},"language":"en","primary_location":{"id":"mag:2389628478","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ200508002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764863165","display_name":"Zhongguo laonianxue zazhi","issn_l":"1005-9202","issn":["1005-9202"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001555","host_organization_name":"Chinese Society of Gerontology","host_organization_lineage":["https://openalex.org/P4324001555"],"host_organization_lineage_names":["Chinese Society of Gerontology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo laonianxue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028083243","display_name":"Niu Zhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Niu Zhan","raw_affiliation_strings":["-Cong, PING Fen, LI Xian, et al"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"-Cong, PING Fen, LI Xian, et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028083243"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31524968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea-hypopnea-syndrome","display_name":"obstructive sleep apnea-hypopnea syndrome","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9959999918937683},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.921999990940094},{"id":"https://openalex.org/keywords/sleep-apnea-severity","display_name":"sleep apnea severity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.9458307027816772},{"id":"https://openalex.org/C2777711342","wikidata":"https://www.wikidata.org/wiki/Q957217","display_name":"Hypopnea","level":4,"score":0.9214534759521484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8246364593505859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7087612748146057},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6071600914001465},{"id":"https://openalex.org/C2775965246","wikidata":"https://www.wikidata.org/wiki/Q4531845","display_name":"Tissue inhibitor of metalloproteinase","level":3,"score":0.5753666758537292},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.5546765923500061},{"id":"https://openalex.org/C2991819120","wikidata":"https://www.wikidata.org/wiki/Q13033749","display_name":"Matrix metalloproteinase 9","level":3,"score":0.5498334765434265},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.515612781047821},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42741259932518005},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.27020275592803955}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2389628478","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZLXZ200508002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764863165","display_name":"Zhongguo laonianxue zazhi","issn_l":"1005-9202","issn":["1005-9202"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001555","host_organization_name":"Chinese Society of Gerontology","host_organization_lineage":["https://openalex.org/P4324001555"],"host_organization_lineage_names":["Chinese Society of Gerontology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo laonianxue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408732859","https://openalex.org/W2378476873","https://openalex.org/W4224785205","https://openalex.org/W2171671476","https://openalex.org/W2374571075","https://openalex.org/W3031944217","https://openalex.org/W2071253071","https://openalex.org/W2791952919","https://openalex.org/W2029663337","https://openalex.org/W3096498937"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3,108,111,137],"levels":[4,32],"of":[5,33,54,84,114,123,139],"matrix":[6],"metalloproteinase-9(MMP-9)":[7],"and":[8,21,35,44,47,60,79,102,125,131],"tissue":[9],"inhibitor":[10],"metalloproteinase-1":[11],"(TIMP-1)":[12],"in":[13,39,58,64,75,88,92,100,127],"patients":[14,41,128],"with":[15,42,67,95,107,129],"obstructiv":[16],"sleep":[17,23,116,141],"apnea-hypopnea":[18,24],"syndrome(":[19],"OSAHS)":[20],"obstructive":[22,115,140],"associated":[25],"hypertension(":[26],"OSA-HAHT).":[27],"Methods":[28],"Using":[29],"ELISA,":[30],"serum":[31],"MMP-9":[34,55,99,124,134],"TIMP-1":[36,76,85,126],"were":[37],"measured":[38],"20":[40],"OSAHS":[43,59,78,101,130],"OSAHAHT":[45,61,89,103],"respectively":[46],"16":[48],"health":[49,93],"peoples.":[50],"Results":[51],"Serum":[52,98,133],"concentration":[53],"was":[56,72,86],"higher":[57,87],"than":[62,90],"those":[63,91],"control":[65,80],"subjects":[66,94],"significant":[68,96,105],"differences,":[69],"but":[70],"there":[71],"no":[73],"difference":[74],"between":[77],"group.":[81],"The":[82],"level":[83],"differences.":[97],"showed":[104],"correlation":[106],"indexes":[109],"reflecting":[110],"severity":[112,138],"degree":[113],"apnea.":[117,142],"Conclusions":[118],"There":[119],"are":[120],"abnormal":[121],"metabolism":[122],"OSAHAHT.":[132],"could":[135],"reflect":[136]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
