{"id":"https://openalex.org/W2389273733","doi":null,"title":"Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease","display_name":"Effect of simvastatin on fatty acids composition of erythrocyte membranes in women with chronic form of coronary heart disease","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2389273733","mag":"2389273733"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:c234296490a64ff2b511ed32bc105907","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c234296490a64ff2b511ed32bc105907","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomedica Scientifica, Vol 0, Iss 5, Pp 22-28 (2013)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/c234296490a64ff2b511ed32bc105907","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079517134","display_name":"\u0410. \u041c. \u0414\u044b\u0433\u0430\u0439","orcid":"https://orcid.org/0000-0001-6286-5315","observed_orcids":["https://orcid.org/0000-0001-6286-5315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. M. Dygai","raw_affiliation_strings":["Scientific Research Institute of Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Institute of Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Yu. Kotlovskiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. Yu. Kotlovskiy","raw_affiliation_strings":["Krasnoyarsk State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk State Medical University","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036772413","display_name":"\u0414. \u0410. \u041a\u0438\u0440\u0438\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-0550-9335","observed_orcids":["https://orcid.org/0000-0003-0550-9335"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. A. Kirichenko","raw_affiliation_strings":["Krasnoyarsk State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk State Medical University","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Yu. Yakimovitch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196530094","display_name":"Siberian State Medical University","ror":"https://ror.org/01yecy831","country_code":"RU","type":"education","lineage":["https://openalex.org/I196530094"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. Yu. Yakimovitch","raw_affiliation_strings":["Siberian State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siberian State Medical University","institution_ids":["https://openalex.org/I196530094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590586","display_name":"\u0414. \u0421. \u0422\u0435\u0440\u0435\u0448\u0438\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. S. Tereshina","raw_affiliation_strings":["Krasnoyarsk State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk State Medical University","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu. V. Kotlovskiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yu. V. Kotlovskiy","raw_affiliation_strings":["Krasnoyarsk State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krasnoyarsk State Medical University","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064840931","display_name":"\u0412. \u041d. \u0422\u0438\u0442\u043e\u0432","orcid":"https://orcid.org/0000-0001-6761-4267","observed_orcids":["https://orcid.org/0000-0001-6761-4267"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. N. Titov","raw_affiliation_strings":["The Russian Cardiology Research and Production Complex"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russian Cardiology Research and Production Complex","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.7807999849319458,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.11630000174045563,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8119999766349792},{"id":"https://openalex.org/keywords/erythrocyte-membrane-fatty-acids","display_name":"erythrocyte membrane fatty acids","score":0.8510000109672546},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7580000162124634},{"id":"https://openalex.org/keywords/atherogenic-index","display_name":"atherogenic index","score":0.8510000109672546},{"id":"https://openalex.org/keywords/unsaturation-index","display_name":"unsaturation index","score":0.7250000238418579},{"id":"https://openalex.org/keywords/n-6-n-3-ratio","display_name":"n-6/n-3 ratio","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dihomo-gamma-linolenic-acid","display_name":"dihomo-gamma-linolenic acid","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.7990000247955322},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.8700000047683716},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vitamin-f","display_name":"vitamin F","score":0.4399999976158142},{"id":"https://openalex.org/keywords/desaturase-enzymes","display_name":"desaturase enzymes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/atheromatosis","display_name":"atheromatosis","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.8698925971984863},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.6490837335586548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.62330162525177},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5230270624160767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5172113180160522},{"id":"https://openalex.org/C2993443003","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Erythrocyte membrane","level":3,"score":0.51067715883255},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.49531570076942444},{"id":"https://openalex.org/C2994432733","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary disease","level":3,"score":0.4451340138912201},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4315856099128723},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4154731035232544},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38974589109420776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2734643220901489},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:c234296490a64ff2b511ed32bc105907","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c234296490a64ff2b511ed32bc105907","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomedica Scientifica, Vol 0, Iss 5, Pp 22-28 (2013)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:c234296490a64ff2b511ed32bc105907","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c234296490a64ff2b511ed32bc105907","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biomedica Scientifica, Vol 0, Iss 5, Pp 22-28 (2013)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1481733466","https://openalex.org/W1600543204","https://openalex.org/W1971808829","https://openalex.org/W2022968393","https://openalex.org/W2114138159","https://openalex.org/W2132982393","https://openalex.org/W2145002256","https://openalex.org/W2183663567","https://openalex.org/W2188039807","https://openalex.org/W2407618083"],"related_works":["https://openalex.org/W3034408389","https://openalex.org/W2884722971","https://openalex.org/W1795748102","https://openalex.org/W2158742086","https://openalex.org/W2442846375","https://openalex.org/W2383057405","https://openalex.org/W2006766721","https://openalex.org/W2404692256","https://openalex.org/W2364760923","https://openalex.org/W3154180083"],"abstract_inverted_index":{"23":[0],"women":[1,192],"with":[2,60,99],"a":[3,113,186],"chronic":[4],"form":[5],"of":[6,18,23,29,54,74,78,93,103,108,115,121,126,132,147,157,160,170,177,181,188,196,203,210,213,216,226,233],"coronary":[7],"heart":[8],"disease":[9],"(CHD)":[10],"were":[11],"examined":[12],"before":[13],"and":[14,25,43,118,130,139,200],"after":[15,97],"two":[16],"months":[17],"taking":[19],"simvastatin":[20],"at":[21,51,185],"doses":[22,180],"40":[24,182],"80":[26,189],"mg/day.":[27],"Regardless":[28],"the":[30,32,52,81,104,109,127,145,151,158,168,175,194,201,208,214,224,231],"dosage":[31,187],"reduction":[33,102,169,176],"in":[34,57,66,71,80,191,219],"total":[35],"cholesterol":[36,41],"(TC)":[37],"level,":[38],"low-density":[39],"lipoprotein":[40],"(LDL-C)":[42],"atherogenic":[44],"index":[45,106],"(Al)":[46],"was":[47,86,95],"found":[48],"that":[49],"pointed":[50],"strengthening":[53],"receptor-mediated":[55],"endocytosis":[56],"LDL-C":[58],"cells":[59,142],"all":[61],"portable":[62],"fatty":[63],"acids":[64],"(FA)":[65],"them":[67],"by":[68,88],"apoB-100":[69],"cells,":[70],"various":[72],"forms":[73],"esters.":[75],"The":[76,124],"spectrum":[77],"FA":[79,94,163,173,228],"erythrocyte":[82],"membrane":[83],"phospholipids":[84],"(FL)":[85],"researched":[87],"gas-liquid":[89],"chromatography-mass":[90],"spectrometry.":[91],"Redistribution":[92],"revealed":[96],"treatment":[98,184],"different":[100],"doses:":[101],"unsaturation":[105],"(UI)":[107],"membranes":[110],"erythrocytes":[111],"indicated":[112,207],"violation":[114],"physical,":[116],"chemical":[117],"functional":[119],"properties":[120],"cell":[122,217],"membranes.":[123],"content":[125],"FA-membrane":[128],"substrates":[129,131,136,141],"vitamin":[133],"F,":[134],"triglycerol":[135],"(TGL)":[137],"decreased":[138],"FA-energy":[140],"increased.":[143],"Probably,":[144],"ability":[146],"statins":[148],"to":[149],"activate":[150],"desaturase":[152],"enzymes":[153],"had":[154],"an":[155],"effect":[156],"increasing":[159],"long-chain":[161],"\u03c9-9":[162,172],"content.":[164],"In":[165],"this":[166],"case":[167],"oleic":[171],"influenced":[174],"TGL.":[178],"Unlike":[179],"mg/day":[183,190],"resulted":[193],"increase":[195],"relation":[197],"\u03c9-3/\u03c9-6":[198],"LC":[199],"decrease":[202],"dihomo-\u03b3-linolenic":[204],"LCD.":[205],"It":[206],"formation":[209],"favorable":[211],"conditions":[212,223],"normalization":[215],"function":[218],"vivo.":[220],"Under":[221],"these":[222],"level":[225],"palmitic":[227],"and,":[229],"correspondingly,":[230],"activity":[232],"atheromatosis":[234],"decreased.":[235]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}