{"id":"https://openalex.org/W2388280714","doi":null,"title":"EFFICACY OF NERVE GROWTH FACTOR ON NEONATES WITH MODERATE AND SEVER HYPOXIC-ISCHEMIC ENCEPHALOPATHY AND ITS INFLUENCE ON SERUM NSE AND S-100\u0392 PROTEIN","display_name":"EFFICACY OF NERVE GROWTH FACTOR ON NEONATES WITH MODERATE AND SEVER HYPOXIC-ISCHEMIC ENCEPHALOPATHY AND ITS INFLUENCE ON SERUM NSE AND S-100\u0392 PROTEIN","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2388280714","mag":"2388280714"},"language":"en","primary_location":{"id":"mag:2388280714","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XDYU201204006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2754556718","display_name":"Modern hospital","issn_l":"0026-783X","issn":["0026-783X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320788","host_organization_name":"McGraw Hill Book Company","host_organization_lineage":["https://openalex.org/P4310320788"],"host_organization_lineage_names":["McGraw Hill Book Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Modern hospital","raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W2388280714"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101529632","display_name":"Ling Liu","orcid":"https://orcid.org/0000-0002-7016-2713","observed_orcids":["https://orcid.org/0000-0002-7016-2713"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ling Liu","raw_affiliation_strings":["et al Department of Pediatrics,Longjiang Hospital of Shunde District,Foshan City,Guangdong Province 528318 PRC"],"raw_orcid":"https://orcid.org/0000-0002-7016-2713","affiliations":[{"raw_affiliation_string":"et al Department of Pediatrics,Longjiang Hospital of Shunde District,Foshan City,Guangdong Province 528318 PRC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101529632"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":1.0},{"id":"https://openalex.org/keywords/hypoxic-ischemic-encephalopathy","display_name":"hypoxic-ischemic encephalopathy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9169999957084656},{"id":"https://openalex.org/keywords/serum-nse","display_name":"serum NSE","score":0.6330000162124634},{"id":"https://openalex.org/keywords/s100b-protein","display_name":"S100B protein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cerebrolysin","display_name":"Cerebrolysin","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nbna-score","display_name":"NBNA score","score":0.8130000233650208},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2776149669","wikidata":"https://www.wikidata.org/wiki/Q19946892","display_name":"Cerebrolysin","level":2,"score":0.9458433389663696},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.9140311479568481},{"id":"https://openalex.org/C2909832856","wikidata":"https://www.wikidata.org/wiki/Q2249526","display_name":"Hypoxic Ischemic Encephalopathy","level":3,"score":0.7923710346221924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7180006504058838},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.6710166335105896},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4687122702598572},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.45355066657066345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44518396258354187},{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.4282938838005066},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41627955436706543},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15855911374092102},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2388280714","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XDYU201204006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2754556718","display_name":"Modern hospital","issn_l":"0026-783X","issn":["0026-783X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320788","host_organization_name":"McGraw Hill Book Company","host_organization_lineage":["https://openalex.org/P4310320788"],"host_organization_lineage_names":["McGraw Hill Book Company"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Modern hospital","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386244992","https://openalex.org/W3031582211","https://openalex.org/W2347724560","https://openalex.org/W2347751625","https://openalex.org/W2380075795","https://openalex.org/W2347482420","https://openalex.org/W2374183842","https://openalex.org/W2391825588","https://openalex.org/W3029354830","https://openalex.org/W2377439875"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3,76,103],"efficacy":[4],"of":[5,78,90,106,119,124,137,142,161],"nerve":[6],"growth":[7,167],"factor(NGF)":[8],"on":[9,20],"neonates":[10,179],"with":[11,29,60,180],"moderate":[12,30],"and":[13,17,23,31,46,102,126,144,148,172,175],"sever":[14,32],"hypoxic-ischemic":[15],"encephalopathy(HIE)":[16],"its":[18],"influence":[19],"serum":[21],"NSE":[22,125,143,171],"S-100\u03b2":[24],"protein.":[25],"Methods":[26],"58":[27],"inpatients":[28],"neonatal":[33],"HIE":[34],"in":[35,110,128,152,178],"our":[36],"Neonatal":[37],"Department":[38],"were":[39,93,114,132,156],"randomly":[40],"divided":[41],"into":[42],"NGF":[43,62,67,111,153],"treatment":[44,48,56,63,112,121,130,151,154,163],"group":[45,57,64,113,155],"routine":[47,55,120,162],"group.In":[49],"addition":[50],"to":[51],"individualized":[52],"supportive":[53],"treatment,the":[54],"was":[58,65],"treated":[59],"cerebrolysin,the":[61],"given":[66],"as":[68,70,95],"early":[69],"possible(within":[71],"twenty-four":[72],"hours":[73],"after":[74,86,150],"birth).What\u2032smore,observed":[75],"changes":[77],"NBNA":[79,100],"score,one":[80],"year":[81],"intellectual":[82,107],"development":[83,108],"quotient,NSE,S-100B":[84],"protein":[85],"treatment.And":[87],"12":[88],"cases":[89],"normal":[91],"newborns":[92],"selected":[94],"healthy":[96,138],"control":[97,139],"group.":[98],"Results":[99],"score":[101],"nornlal":[104],"rate":[105],"quotient":[109],"significantly":[115],"higher":[116,134],"than":[117,135,159],"those":[118,136,160],"group(p0.05).The":[122],"levels":[123,141],"S-100B":[127,145,173],"two":[129],"groups":[131],"significant":[133,157],"group(p0.01).The":[140],"at":[146],"3d":[147],"7d":[149],"lower":[158],"group(p0.05).":[164],"Conclusion":[165],"Nerve":[166],"factor":[168],"may":[169],"reduce":[170],"rerease":[174],"exert":[176],"neuroprotection":[177],"HIE.":[181]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
