{"id":"https://openalex.org/W2387617653","doi":null,"title":"Change in angiotension-converting enzyme mRNA expression in organ cultured human saphenous veins","display_name":"Change in angiotension-converting enzyme mRNA expression in organ cultured human saphenous veins","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2387617653","mag":"2387617653"},"language":"en","primary_location":{"id":"mag:2387617653","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/abstract/CBA/340538","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100451687","display_name":"Yuqi Wang","orcid":"https://orcid.org/0000-0002-9793-6002","observed_orcids":["https://orcid.org/0000-0002-9793-6002","https://orcid.org/0009-0003-9580-6145","https://orcid.org/0009-0004-8224-4689","https://orcid.org/0009-0008-9122-6086","https://orcid.org/0009-0007-7862-2570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuqi Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9793-6002","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000498643","display_name":"Wangde Dai","orcid":"https://orcid.org/0000-0003-4797-0138","observed_orcids":["https://orcid.org/0000-0003-4797-0138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dai Wangde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102019851","display_name":"Weiguo Fu","orcid":"https://orcid.org/0000-0002-6200-2859","observed_orcids":["https://orcid.org/0000-0002-6200-2859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiguo Fu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6200-2859","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30799133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"3","first_page":"203","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ace-mrna-expression","display_name":"ACE mRNA expression","score":0.9599999785423279},{"id":"https://openalex.org/keywords/human-saphenous-vein","display_name":"human saphenous vein","score":0.9369999766349792},{"id":"https://openalex.org/keywords/organ-culture","display_name":"organ culture","score":0.859000027179718},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.4650000035762787},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2910238305","wikidata":"https://www.wikidata.org/wiki/Q3473165","display_name":"Saphenous veins","level":3,"score":0.8493031859397888},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7461296319961548},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.7330054640769958},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5095160603523254},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.47328469157218933},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.46388891339302063},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.45566290616989136},{"id":"https://openalex.org/C2779480337","wikidata":"https://www.wikidata.org/wiki/Q543323","display_name":"Great saphenous vein","level":3,"score":0.4507914185523987},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.4342743158340454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37276095151901245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37185990810394287},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.346246600151062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3299485445022583},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3240628242492676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2855040431022644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18207094073295593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11893594264984131},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2387617653","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/abstract/CBA/340538","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2291797470","https://openalex.org/W2032292284","https://openalex.org/W2052465151","https://openalex.org/W2414498992","https://openalex.org/W2124796095","https://openalex.org/W1972485378","https://openalex.org/W3140607889","https://openalex.org/W2362312918","https://openalex.org/W2045407991","https://openalex.org/W1979179362"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,27,51,62,75],"changes":[3],"in":[4,10,31,61,74,92],"angiotensin-converting":[5],"enzyme":[6],"(ACE)":[7],"mRNA":[8,29,60,88],"expression":[9,30,85],"organ":[11,93],"cultured":[12,37,53,94],"human":[13,95],"saphenous":[14,43,96],"veins.":[15,97],"Methods":[16],"Reverse":[17],"tranmcription":[18],"polymerase":[19],"chain":[20],"reaction":[21],"(RT-PCR)":[22],"was":[23,47,65,89],"used":[24],"to":[25],"detect":[26],"ACE":[28,59,87],"30":[32],"pre-oulture":[33],"veins":[34,36,52],"and":[35],"for":[38,54],"14":[39,55],"days.":[40,56],"Results":[41],"Human":[42],"vein":[44],"intimal":[45],"thickness":[46],"increased":[48,90],"significantly":[49,71,91],"after":[50],"Expression":[57],"of":[58,86],"experimental":[63],"group":[64,77],"0.777+":[66],"-":[67],"0.143":[68],"(n=":[69,80],"30),":[70],"higher":[72],"than":[73],"control":[76],"0.347+":[78],"-0.158":[79],"30,":[81],"P<0.001).":[82],"Conclusion":[83],"The":[84]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}