{"id":"https://openalex.org/W2387417151","doi":null,"title":"CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders.","display_name":"CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders.","publication_year":2015,"publication_date":"2015-04-25","ids":{"openalex":"https://openalex.org/W2387417151","mag":"2387417151","pmid":"https://pubmed.ncbi.nlm.nih.gov/25896045"},"language":"en","primary_location":{"id":"pmid:25896045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25896045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009367224","display_name":"Zhifang Xue","orcid":"https://orcid.org/0009-0006-7518-6585","observed_orcids":["https://orcid.org/0009-0006-7518-6585"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan-Cheng Xue","raw_affiliation_strings":["School of Medicine, Ningbo University, Ningbo 315211, China","Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434691","display_name":"Chuang Wang","orcid":"https://orcid.org/0000-0002-3816-230X","observed_orcids":["https://orcid.org/0000-0002-3816-230X"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuang Wang","raw_affiliation_strings":["School of Medicine, Ningbo University, Ningbo 315211, China","Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001736408","display_name":"Qinwen Wang","orcid":"https://orcid.org/0000-0001-9809-9384","observed_orcids":["https://orcid.org/0000-0001-9809-9384"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin-Wen Wang","raw_affiliation_strings":["School of Medicine, Ningbo University, Ningbo 315211, China","Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100743319","display_name":"Junfang Zhang","orcid":"https://orcid.org/0000-0001-5969-4789","observed_orcids":["https://orcid.org/0000-0001-5969-4789"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Fang Zhang","raw_affiliation_strings":["School of Medicine, Ningbo University, Ningbo 315211, China","Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China. zhangjunfang@nbu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Ningbo University, Ningbo 315211, China","institution_ids":["https://openalex.org/I109935558"]},{"raw_affiliation_string":"Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China. zhangjunfang@nbu.edu.cn","institution_ids":["https://openalex.org/I109935558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I109935558"],"apc_list":null,"apc_paid":null,"fwci":0.8076,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7029837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"67","issue":"2","first_page":"155","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.20149999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.20149999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.18850000202655792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.1590999960899353,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crtc1","display_name":"CRTC1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8740000128746033},{"id":"https://openalex.org/keywords/camp-response-element","display_name":"cAMP response element","score":0.9129999876022339},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/memory-reconsolidation","display_name":"memory reconsolidation","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.9626152515411377},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.7905474901199341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6537374258041382},{"id":"https://openalex.org/C48455012","wikidata":"https://www.wikidata.org/wiki/Q2892593","display_name":"Memory consolidation","level":3,"score":0.6471401453018188},{"id":"https://openalex.org/C2909511254","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"Cyclic AMP Response Element-Binding Protein","level":5,"score":0.5984795093536377},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5525854229927063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4917050004005432},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.48890724778175354},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.4781542718410492},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4542660117149353},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.4198463261127472},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.411003977060318},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36934661865234375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2876761555671692},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2626744508743286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24302873015403748},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07214590907096863},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:25896045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25896045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:2387417151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25896045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2358144439","https://openalex.org/W2766514860","https://openalex.org/W2092896141","https://openalex.org/W4386573004","https://openalex.org/W2031608523","https://openalex.org/W2065432433","https://openalex.org/W6992035261","https://openalex.org/W2994417359","https://openalex.org/W1608481794","https://openalex.org/W1966615413"],"abstract_inverted_index":{"The":[0,30],"cAMP-responsive":[1],"element":[2,26],"binding":[3],"protein":[4],"(CREB)-regulated":[5],"transcription":[6],"coactivator,":[7],"CRTC":[8,31],"(also":[9],"known":[10],"as":[11,19],"transducer":[12],"of":[13,23,34,73,83],"regulated":[14],"CREB,":[15],"TORC),":[16],"is":[17,75],"identified":[18],"a":[20],"potent":[21],"modulator":[22],"cAMP":[24],"response":[25],"(CRE)-driven":[27],"gene":[28],"transcription.":[29],"family":[32],"consists":[33],"three":[35],"members":[36],"(CRTC1-3),":[37],"among":[38],"which":[39],"the":[40,43,47,54,95,103],"CRTC1":[41,55,74,96],"shows":[42],"highest":[44],"expression":[45],"in":[46,59,78,102],"brain.":[48],"Several":[49],"studies":[50],"have":[51],"demonstrated":[52],"that":[53,93],"plays":[56],"critical":[57],"roles":[58],"neuronal":[60],"dendritic":[61],"growth,":[62],"long-term":[63],"synaptic":[64],"plasticity,":[65],"memory":[66],"consolidation":[67],"and":[68,98],"reconsolidation":[69],"etc.,":[70],"whereas":[71],"dysfunction":[72,97],"mainly":[76],"involved":[77],"neurodegenerative":[79,104],"disorders.":[80,105],"In":[81],"light":[82],"these":[84],"findings,":[85],"we":[86],"aim":[87],"to":[88],"review":[89],"recent":[90],"research":[91],"reports":[92],"indicate":[94],"its":[99],"underlying":[100],"mechanisms":[101]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
