{"id":"https://openalex.org/W2387251069","doi":null,"title":"Experimental study of autologous bone with BMP-2and/or VEGF repair open bone defect under seawater immersion","display_name":"Experimental study of autologous bone with BMP-2and/or VEGF repair open bone defect under seawater immersion","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2387251069","mag":"2387251069"},"language":"en","primary_location":{"id":"mag:2387251069","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-AHYX201305003.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058412880","display_name":"Pla Affiliated","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pla Affiliated","raw_affiliation_strings":["to Anhui Medical University,HeFei 230031,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"to Anhui Medical University,HeFei 230031,China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058412880"],"corresponding_institution_ids":["https://openalex.org/I197869895"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27530585,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/seawater-immersion","display_name":"seawater immersion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/autologous-bone-graft","display_name":"autologous bone graft","score":0.8289999961853027},{"id":"https://openalex.org/keywords/absorbable-collagen-sponge","display_name":"absorbable collagen sponge","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.5849999785423279},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.8109999895095825},{"id":"https://openalex.org/keywords/callus-formation","display_name":"callus formation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/iliac-crest-bone-graft","display_name":"iliac crest bone graft","score":0.6290000081062317},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5454642176628113},{"id":"https://openalex.org/C9549007","wikidata":"https://www.wikidata.org/wiki/Q1072909","display_name":"Callus","level":2,"score":0.5432294011116028},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.5302509665489197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5112528800964355},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.47939014434814453},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.43926411867141724},{"id":"https://openalex.org/C2776337968","wikidata":"https://www.wikidata.org/wiki/Q3814234","display_name":"Bone grafting","level":2,"score":0.43209707736968994},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.43167638778686523},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42435187101364136},{"id":"https://openalex.org/C10562115","wikidata":"https://www.wikidata.org/wiki/Q4117711","display_name":"Artificial seawater","level":3,"score":0.41432249546051025},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3324979245662689},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32659733295440674},{"id":"https://openalex.org/C197248824","wikidata":"https://www.wikidata.org/wiki/Q184395","display_name":"Seawater","level":2,"score":0.2763265371322632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26711124181747437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.248275488615036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22609490156173706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12936511635780334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06330010294914246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2387251069","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-AHYX201305003.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1213882570","https://openalex.org/W3031240390","https://openalex.org/W2361968729","https://openalex.org/W3029444953","https://openalex.org/W3031840968","https://openalex.org/W3120432157","https://openalex.org/W3195662803","https://openalex.org/W1006902033","https://openalex.org/W2360141916","https://openalex.org/W2386096817"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,39,50,98,112,117,213,217,246,253],"efficacy":[4],"of":[5,41,157,168,199,216,239],"BMP-2":[6,75,203,224,240],"and":[7,10,32,44,66,74,81,87,94,111,129,145,149,160,179,191,204,225,241],"VEGF":[8,82,88,205,226,242],"single":[9],"combined":[11,214,237,254],"repair":[12],"application":[13,215,238,255],"for":[14,52,107,116],"open":[15,118,232,249],"bone":[16,34,210,233,250],"defect":[17,35,119,211,234,251],"with":[18,166],"seawater":[19,51,121,230,247],"immersion.Methods":[20],"Sixty":[21],"New":[22],"Zealand":[23],"rabbits":[24,40,138],"were":[25,47,76,92],"divided":[26],"into":[27,49,78,83,89],"A,B,C,and":[28],"D":[29,67,161,181],"groups":[30,158],"randomly":[31,110],"averagely.1.5cm":[33],"was":[36,56,63,68,123,162,182],"made":[37],"using":[38],"bilateral":[42],"radius":[43],"then":[45],"they":[46],"put":[48],"three":[53],"hours.Group":[54],"A":[55],"as":[57,69],"control":[58],"group,into":[59],"which":[60],"autologous":[61],"iliac":[62],"implanted;Group":[64],"B,C":[65,159,178],"experimental":[70],"group;iliac,absorbable":[71],"collagen":[72],"sponge(ACS)":[73],"implanted":[77],"group":[79,84,90,103,137,169,177,180,189],"B,iliac,ACS":[80],"C,and":[85],"iliac,ACS,BMP-2":[86],"D.Animals":[91],"sacrificed":[93],"cut":[95],"specimens":[96,106],"in":[97,135,153,172,208],"1st,2nd,4th,8th,12th":[99],"week":[100],"after":[101,114],"grafting.Each":[102],"took":[104],"six":[105],"each":[108],"phase":[109],"healing":[113],"grafting":[115],"under":[120],"immersion":[122,231,248],"observed":[124],"by":[125],"imaging":[126],"observation,histologic":[127],"observation,immunohistochemistry":[128],"environmental":[130],"scanning":[131],"electron":[132],"microscopy.Results":[133],"\u2460X-ray":[134],"every":[136],"had":[139,219],"no":[140,194],"significant":[141,164,195],"difference":[142,152,171],"during":[143],"1st":[144],"2nd":[146],"week.During":[147],"4th,8th":[148],"12th":[150],"week,the":[151],"callus":[154,173,185],"gray":[155,174,186],"value":[156,175,187],"statistically":[163,183],"compared":[165],"that":[167,202],"A(P0.05);the":[170],"between":[176,188],"significant(P0.05);the":[184],"B":[190],"C":[192],"showed":[193,201],"difference(P0.05).\u2461":[196],"The":[197,236],"results":[198],"immunohistochemistry":[200],"mutually":[206],"promoted":[207],"early":[209],"repairing,and":[212],"two":[218],"a":[220],"synergistic":[221],"effect.Conclusion":[222],"\u2460Both":[223],"can":[227,243],"individually":[228],"promote":[229,244],"repair.\u2461":[235],"remarkably":[245],"repair,and":[252],"has":[256],"synergetic":[257],"effects.":[258]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}