{"id":"https://openalex.org/W2386647","doi":null,"title":"Influence of caloric restriction on aging immune system.","display_name":"Influence of caloric restriction on aging immune system.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2386647","mag":"2386647","pmid":"https://pubmed.ncbi.nlm.nih.gov/14730366"},"language":"en","primary_location":{"id":"pmid:14730366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039978851","display_name":"Mohammad A. Pahlavani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802109968","display_name":"Audie L. Murphy Memorial VA Hospital","ror":"https://ror.org/035xhk118","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802109968","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M A Pahlavani","raw_affiliation_strings":["Geriatric Research, Education, and Clinical Center (GRECC - 182) Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Minter Boulevard, San Antonio, TX 78284, USA. Pahlavani@uthscsa.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Research, Education, and Clinical Center (GRECC - 182) Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Minter Boulevard, San Antonio, TX 78284, USA. Pahlavani@uthscsa.edu","institution_ids":["https://openalex.org/I2802109968"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039978851"],"corresponding_institution_ids":["https://openalex.org/I2802109968"],"apc_list":null,"apc_paid":null,"fwci":2.0414,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.8635634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"38","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":1.0},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8679999709129333},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8100000023841858},{"id":"https://openalex.org/keywords/immune-system","display_name":"immune system","score":0.972000002861023},{"id":"https://openalex.org/keywords/nutrition-and-aging","display_name":"nutrition and aging","score":0.6510000228881836},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rodents","display_name":"rodents","score":0.4659999907016754},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.8119123578071594},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7122409343719482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6936458349227905},{"id":"https://openalex.org/C190362976","wikidata":"https://www.wikidata.org/wiki/Q845261","display_name":"Caloric theory","level":2,"score":0.607052743434906},{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.5744211077690125},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5384419560432434},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.527898371219635},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4766136705875397},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47075775265693665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3853324353694916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37665605545043945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3394060730934143},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32129859924316406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23685842752456665},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14730366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},{"id":"mag:2386647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14730366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G930519533","display_name":"TRANSCRIPTION FACTOR NFAT AND AGING IMMUNE SYSTEM","funder_award_id":"R01AG014088","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132105766","https://openalex.org/W3200338334","https://openalex.org/W4286252774","https://openalex.org/W2084350193","https://openalex.org/W2264904772","https://openalex.org/W4401550823","https://openalex.org/W2072712640","https://openalex.org/W2346763599","https://openalex.org/W158867143","https://openalex.org/W2604348394"],"abstract_inverted_index":{"Nutrition":[0],"has":[1,31],"been":[2],"shown":[3],"to":[4,54],"have":[5],"a":[6,49,73],"significant":[7],"impact":[8],"on":[9,34],"aging.":[10],"Caloric":[11],"Restriction":[12],"(CR),":[13],"i.e.,":[14],"undernutrition":[15],"not":[16],"malnutrition,":[17],"significantly":[18],"increases":[19],"the":[20,27,39,43,55,59,89,92,99,102],"survival":[21],"of":[22,46,58,94,101],"laboratory":[23,87],"animals":[24],"by":[25],"retarding/delaying":[26],"aging":[28,69],"process.":[29],"CR":[30,66,95],"beneficial":[32],"effects":[33],"various":[35],"physiological":[36],"systems,":[37],"including":[38],"immune":[40],"system.":[41],"Overall,":[42],"immunological":[44,56],"status":[45,57],"rodents":[47],"fed":[48],"restricted":[50],"diet":[51],"is":[52,63],"superior":[53],"non-restricted":[60],"animals.":[61],"It":[62],"believed":[64],"that":[65,91,110],"might":[67],"retard":[68],"and":[70,80,106],"immunosenescence":[71],"through":[72],"mechanism":[74,93],"involving":[75],"changes":[76,97],"in":[77,98],"signal":[78],"transduction":[79],"gene":[81,108],"expression.":[82],"Recent":[83],"studies":[84],"from":[85],"our":[86],"support":[88],"view":[90],"involves":[96],"activation":[100],"upstream":[103],"signaling":[104],"molecules":[105],"cytokine":[107],"expression":[109],"are":[111],"altered":[112],"with":[113],"age.":[114]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}