{"id":"https://openalex.org/W2386200419","doi":null,"title":"Curcumin inhibits the proliferation of rat airway smooth muscle cells","display_name":"Curcumin inhibits the proliferation of rat airway smooth muscle cells","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2386200419","mag":"2386200419"},"language":"en","primary_location":{"id":"mag:2386200419","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXDY200820005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764930156","display_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","issn_l":"1005-8982","issn":["1005-8982"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727480","host_organization_name":"Danan University, Ministry of Health","host_organization_lineage":["https://openalex.org/P4361727480"],"host_organization_lineage_names":["Danan University, Ministry of Health"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019595151","display_name":"Bai Hong-bo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bai Hong-bo","raw_affiliation_strings":["Department of Physiology, Basic Medical School, Guangzhou Medical College, Guangzhou, Guangdong 510182, P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Basic Medical School, Guangzhou Medical College, Guangzhou, Guangdong 510182, P","institution_ids":["https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019595151"],"corresponding_institution_ids":["https://openalex.org/I92039509"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31134021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/airway-smooth-muscle-cells","display_name":"airway smooth muscle cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9502055644989014},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.7208425402641296},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5231272578239441},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49392205476760864},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4626482427120209},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.46237727999687195},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.44516533613204956},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3980903625488281},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3912324011325836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3800598978996277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36340397596359253},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3513399660587311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3425421118736267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3104252815246582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2881813943386078},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.2550703287124634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23261746764183044},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18188366293907166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2386200419","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXDY200820005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764930156","display_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","issn_l":"1005-8982","issn":["1005-8982"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727480","host_organization_name":"Danan University, Ministry of Health","host_organization_lineage":["https://openalex.org/P4361727480"],"host_organization_lineage_names":["Danan University, Ministry of Health"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2354081195","https://openalex.org/W2023008881","https://openalex.org/W4200385850","https://openalex.org/W2377354602","https://openalex.org/W2382812336","https://openalex.org/W2077763435","https://openalex.org/W2365248515","https://openalex.org/W2371980829","https://openalex.org/W3030536362","https://openalex.org/W2056583260"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,8,32,44,50,67,106],"effect":[4],"of":[5,10,17,23,56,70,111,135,155,168,170],"curcumin":[6,36,95],"on":[7],"proliferation":[9,45,154],"airway":[11],"smooth":[12],"muscle":[13],"cells(ASMCs).Methods":[14],"Primary":[15],"ASMCs":[16,24,156],"rats":[18],"were":[19,37,59,83,131,138],"cultured.The":[20],"absorbance(A450)":[21,68],"value":[22,69],"with":[25,27,64,88,94,103,151],"treatment":[26,87,148],"platelet-derived":[28],"growth":[29],"factor(PDGF)":[30],"in":[31],"presence":[33],"or":[34],"absence":[35],"detected":[38],"by":[39,47,53,61,159],"CCK-8":[40],"kits":[41],"to":[42,166],"abserve":[43],"induced":[46,52],"PDGF":[48,74,80,89],"and":[49,76,99,116,122,124,129,144,161],"antiproliferation":[51],"curcumin.The":[54],"levels":[55,134],"ERK1/2":[57,136],"protein":[58,137],"determined":[60],"western":[62],"blotting.ResultsCompared":[63],"control":[65,104],"group(1.04\u00b10.12),":[66],"10":[71],"ng/":[72,78],"mL":[73,79],"group(1.16\u00b10.14)":[75],"50":[77],"group(1.30\u00b10.15)":[81],"both":[82],"increased":[84,132],"significantly":[85,139],"after":[86,147],"at":[90,96,141],"2":[91],"days(P0.01).After":[92],"incubation":[93],"12,":[97],"24":[98],"36":[100],"hours,":[101],"compared":[102],"group,":[105],"average":[107],"cell":[108],"inhibition":[109,167],"rates":[110],"11.25":[112],"\u03bcmol/L":[113,119,126],"group(21.57%,":[114],"43.55%":[115],"65.99%),":[117],"16.88":[118],"group(39.64%,":[120],"57.44%":[121],"77.80%)":[123],"25.31":[125],"group(44.50%,":[127],"53.68%":[128],"92.68%)":[130],"significantly(P0.05).The":[133],"decreased":[140],"20,":[142],"40":[143],"60":[145],"minutes":[146],"curcumin(25":[149],"\u03bcmol/L)":[150],"PDGF(25":[152],"ng/mL).ConclusionsThe":[153],"was":[157],"inhibited":[158],"curcumin,":[160],"this":[162],"may":[163],"be":[164],"ralated":[165],"activation":[169],"ERK":[171],"signaling":[172],"pathway.":[173]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}