{"id":"https://openalex.org/W2385848124","doi":null,"title":"Isolation and purification of human cardiac troponin I using affinity chromatography","display_name":"Isolation and purification of human cardiac troponin I using affinity chromatography","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2385848124","mag":"2385848124"},"language":"en","primary_location":{"id":"mag:2385848124","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SHYY200703027.htm","pdf_url":null,"source":{"id":"https://openalex.org/S19362967","display_name":"Laboratory Medicine","issn_l":"0007-5027","issn":["0007-5027","1943-7730"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Laboratory Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002476958","display_name":"MA Hongwei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"MA Hongwei","raw_affiliation_strings":["~1,ZHAO Weiguo~2,PAN Baishen~1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"~1,ZHAO Weiguo~2,PAN Baishen~1","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002476958"],"corresponding_institution_ids":[],"apc_list":{"value":4535,"currency":"USD","value_usd":4535},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24767272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.7045999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.23399999737739563,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-troponin-i","display_name":"cardiac troponin I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/troponin-c","display_name":"troponin C","score":0.8059999942779541},{"id":"https://openalex.org/keywords/affinity-chromatography","display_name":"affinity chromatography","score":0.8659999966621399},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.8700000047683716},{"id":"https://openalex.org/keywords/acute-myocardial-infarction-diagnosis","display_name":"acute myocardial infarction diagnosis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.8582140803337097},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.7060898542404175},{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.6848801374435425},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.6834962368011475},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.6735507249832153},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6071064472198486},{"id":"https://openalex.org/C101660505","wikidata":"https://www.wikidata.org/wiki/Q898301","display_name":"Polyacrylamide gel electrophoresis","level":3,"score":0.541847825050354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5076621770858765},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5054852962493896},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.49288082122802734},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.45369839668273926},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.352891206741333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3486206829547882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23723474144935608},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21228653192520142},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.2023417353630066},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13584664463996887},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.10595172643661499},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07044172286987305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2385848124","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SHYY200703027.htm","pdf_url":null,"source":{"id":"https://openalex.org/S19362967","display_name":"Laboratory Medicine","issn_l":"0007-5027","issn":["0007-5027","1943-7730"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Laboratory Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2374287987","https://openalex.org/W2371016400","https://openalex.org/W64961806","https://openalex.org/W2349399747","https://openalex.org/W2368052629","https://openalex.org/W2368699716","https://openalex.org/W2352449182","https://openalex.org/W2598473508","https://openalex.org/W2979357907","https://openalex.org/W2363179645"],"abstract_inverted_index":{"Objective":[0],"To":[1],"isolate":[2],"and":[3,17,26,59,104,130],"purify":[4],"cardiac":[5,10,42,73,118],"troponin":[6],"\u2160(cTnI)":[7],"from":[8,19,40,69],"human":[9,41,72,117],"muscle.":[11],"Methods":[12],"Troponin":[13],"C(TnC)":[14],"was":[15,37,51,75,82,94],"separated":[16],"purified":[18,38,49],"rabbit":[20],"skeletal":[21],"muscle":[22,43,74,119],"by":[23,44,53,97],"ion":[24],"exchange":[25],"hydrophobic":[27],"interaction":[28],"chromatography":[29,35,47],"to":[30,135],"prepare":[31],"TnC-Sepharose":[32],"4B":[33],"affinity":[34,46],"column.cTnI":[36],"directly":[39],"the":[45,80,109,137],"method.The":[48],"cTnI":[50,67,81,93,110,123],"identified":[52],"sodium":[54],"dodecyl":[55],"sulfate-polyacrylamide":[56],"gel":[57],"electrophoresis(SDS-PAGE)":[58],"Western":[60,98,105],"blotting.":[61],"Results":[62],"The":[63],"total":[64],"yield":[65],"of":[66,90,108,116],"obtained":[68],"10":[70],"g":[71],"2.44":[76],"mg.SDS-PAGE":[77],"proved":[78],"that":[79],"electrophoretic":[83],"pure":[84],"with":[85,113,124],"an":[86],"apparent":[87],"molecular":[88],"weights":[89],"29":[91],"000.The":[92],"also":[95],"confirmed":[96],"blotting":[99,106],"using":[100],"specific":[101],"monoclonal":[102],"antibody.SDS-PAGE":[103],"results":[107],"were":[111],"identical":[112],"commercial":[114],"preparation":[115],"cTnI.":[120],"Conclusions":[121],"Natural":[122],"immunological":[125],"activity":[126],"is":[127],"successfully":[128],"isolated":[129],"purified.It":[131],"will":[132],"be":[133],"helpful":[134],"develop":[136],"diagnostic":[138],"kit":[139],"for":[140],"acute":[141],"myocardial":[142],"infarction.":[143]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
