{"id":"https://openalex.org/W2385641592","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","title":"Use of high-sensitivity cardiac troponin T to predict changes in left ventricular function in cancer patients treated with doxorubicin.","display_name":"Use of high-sensitivity cardiac troponin T to predict changes in left ventricular function in cancer patients treated with doxorubicin.","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2385641592","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","mag":"2385641592"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.e19504","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029742591","display_name":"Ayesha Rehman","orcid":"https://orcid.org/0009-0008-0395-3436","observed_orcids":["https://orcid.org/0009-0008-0395-3436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rehman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040813731","display_name":"Anne Hudson Blaes","orcid":"https://orcid.org/0000-0002-5433-4810","observed_orcids":["https://orcid.org/0000-0002-5433-4810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. H. Blaes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074529767","display_name":"Xiu\u2010Xia Luo","orcid":"https://orcid.org/0000-0003-3989-8068","observed_orcids":["https://orcid.org/0000-0003-3989-8068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108545888","display_name":"M. R. Menge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. R. Menge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064860207","display_name":"Derek Yee","orcid":"https://orcid.org/0000-0002-3609-303X","observed_orcids":["https://orcid.org/0000-0002-3609-303X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Yee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028430669","display_name":"Emile Missov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Missov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"e19504","last_page":"e19504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-troponin-t","display_name":"high-sensitivity troponin T","score":0.9700000286102295},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.5789999961853027},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9359999895095825},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":1.0},{"id":"https://openalex.org/keywords/cumulative-doxorubicin-dose","display_name":"cumulative doxorubicin dose","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.884142279624939},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.8422319889068604},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7579934597015381},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7462314367294312},{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.6922542452812195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6201191544532776},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.584559977054596},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.5302115678787231},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.5047868490219116},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4828975200653076},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.44334033131599426},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4271353483200073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37225356698036194},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3697461187839508},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35615819692611694},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09521734714508057}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.e19504","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.e19504","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168137676","https://openalex.org/W2013195452","https://openalex.org/W3152041689","https://openalex.org/W2082155590","https://openalex.org/W2402927453","https://openalex.org/W2334709023","https://openalex.org/W2157047587","https://openalex.org/W2058525629","https://openalex.org/W1863553834","https://openalex.org/W2069347095"],"abstract_inverted_index":{"e19504":[0],"Background:":[1],"The":[2,26,208],"use":[3,209],"of":[4,28,113,146,154,168,206,210],"doxorubicin":[5,23,95,166],"to":[6,22,32,54,131,159,188,223],"treat":[7],"solid":[8],"and":[9,77,91,122],"hematological":[10],"malignancies":[11],"is":[12,31],"limited":[13],"by":[14,100],"a":[15,35,150,164,211],"dose-dependent":[16],"cardiotoxicity.":[17],"Predicting":[18],"individual":[19],"patient":[20],"susceptibility":[21],"remains":[24],"difficult.":[25],"objective":[27],"this":[29],"study":[30],"determine":[33],"if":[34],"new":[36],"generation":[37],"high-sensitivity":[38],"cardiac":[39,79],"troponin":[40,80],"T":[41,81],"assay":[42,214],"(hscTnT)":[43],"can":[44],"predict":[45],"changes":[46,195],"in":[47,109,119,180,196,198],"left":[48],"ventricular":[49],"ejection":[50],"fraction":[51],"(LVEF)":[52],"secondary":[53],"treatment":[55,129],"with":[56,61,177,201],"doxorubicin.":[57,207],"Methods:":[58],"Eighteen":[59],"patients":[60,121,148,199],"breast":[62],"carcinoma":[63],"or":[64],"non-Hodgkin":[65],"lymphoma":[66],"were":[67,87,123],"enrolled.":[68],"Blood":[69],"samples":[70],"for":[71],"hscTnT":[72,114,172],"(detection":[73],"limit":[74,84],"<1":[75],"pg/mL)":[76],"traditional":[78],"(cTnT,":[82],"detection":[83],"<0.01":[85],"ng/mL)":[86],"drawn":[88],"at":[89,105],"baseline":[90,132],"after":[92,126,162],"the":[93,106,127,147,178],"last":[94,128],"treatment.":[96],"LVEF":[97,152,181,197],"was":[98],"measured":[99],"multi":[101],"gated":[102],"acquisition":[103],"scan":[104],"same":[107],"points":[108],"time.":[110],"Results:":[111],"Levels":[112],"but":[115,173],"not":[116,174],"cTnT":[117,175,193],"increased":[118],"all":[120],"significantly":[124],"higher":[125],"compared":[130],"(22.18":[133],"\u00b1":[134,139],"4.71":[135],"pg/mL":[136],"vs":[137],"2.33":[138],"0.66":[140],"pg/mL,":[141],"P=0.0006).":[142],"Sixty":[143],"seven":[144],"percent":[145],"had":[149],"mean":[151],"decline":[153],"6%":[155],"(95%":[156],"CI":[157,186],"3":[158],"9,":[160],"P<0.01)":[161],"receiving":[163],"cumulative":[165,204],"dose":[167,205],"240":[169],"mg/m2.":[170],"Baseline":[171],"correlated":[176],"change":[179],"(Spearman":[182],"correlation":[183],"-0.54,":[184],"95%":[185],"-0.80":[187],"-0.08,":[189],"P=0.02).":[190],"Conclusions:":[191],"High-sensitivity":[192],"predicts":[194],"treated":[200],"an":[202],"intermediate":[203],"more":[212],"sensitive":[213],"provides":[215],"clinically":[216],"relevant":[217],"information.":[218],"No":[219],"significant":[220],"financial":[221],"relationships":[222],"disclose.":[224]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}