{"id":"https://openalex.org/W2385164785","doi":null,"title":"Microencapsulated porcine hepatocyte transplantation to treat acute hepatic failure of rats induced by drug","display_name":"Microencapsulated porcine hepatocyte transplantation to treat acute hepatic failure of rats induced by drug","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2385164785","mag":"2385164785"},"language":"en","primary_location":{"id":"mag:2385164785","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHSY200512013.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013762221","display_name":"Wu-Jun Xiong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wu-Jun Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5013762221"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37466994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.25999999046325684,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-hepatocytes","display_name":"porcine hepatocytes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.8560000061988831},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9120000004768372},{"id":"https://openalex.org/keywords/d-galactosamine","display_name":"D-galactosamine","score":0.8569999933242798},{"id":"https://openalex.org/keywords/alginate-encapsulation","display_name":"alginate encapsulation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/intraperitoneal-transplantation","display_name":"intraperitoneal transplantation","score":0.871999979019165},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.6880000233650208},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.5649999976158142},{"id":"https://openalex.org/keywords/collagenase-perfusion","display_name":"collagenase perfusion","score":0.640999972820282},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.7407727241516113},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.7404797673225403},{"id":"https://openalex.org/C2911218954","wikidata":"https://www.wikidata.org/wiki/Q1192530","display_name":"Acute hepatic failure","level":3,"score":0.7275437116622925},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.704860508441925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5499613881111145},{"id":"https://openalex.org/C2994203108","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Hepatic function","level":2,"score":0.5257062315940857},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.46333423256874084},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4494299292564392},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44382524490356445},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.439574658870697},{"id":"https://openalex.org/C2994427840","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Liver failure","level":2,"score":0.3269442915916443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29721373319625854},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20683163404464722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0723007321357727},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2385164785","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHSY200512013.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2385082325","https://openalex.org/W2379193950","https://openalex.org/W2353322836","https://openalex.org/W2389638473","https://openalex.org/W2350933404","https://openalex.org/W2391671903","https://openalex.org/W2288953363","https://openalex.org/W2089046164","https://openalex.org/W2440495573","https://openalex.org/W123505413"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,20,24,30,49,54,77,93,150],"therapeutic":[4],"effect":[5],"of":[6,26,29,62,90,152],"microencapsulated":[7,115],"porcine":[8,116],"hepatocytes":[9,42,50],"transplanted":[10,58,83],"intraperitoneally":[11,84],"on":[12],"toxic":[13],"hepatic":[14,27,66,74,88],"failure":[15,67],"in":[16,76,114,123,149],"rats":[17,78],"and":[18,23,57,73,92,96,110],"observe":[19],"survival":[21,71,112],"rate":[22,72,113],"change":[25],"function":[28,75,89],"recipient":[31],"rats.":[32,69],"Methods":[33],"The":[34,70],"collagenase":[35],"perfusing":[36],"method":[37,56],"was":[38,120],"used":[39],"to":[40],"separate":[41],"from":[43],"pup":[44],"pig":[45],"liver.":[46],"And":[47],"then":[48],"were":[51,79,98],"encapsulated":[52],"by":[53],"alginate":[55],"into":[59],"abdominal":[60],"cavity":[61],"D":[63],"gal-induced":[64],"acute":[65],"(AHF)":[68],"determined.":[80],"Results":[81],"Hepatocytes":[82],"could":[85],"improve":[86],"greatly":[87],"rats,":[91],"ALT,":[94],"AST":[95],"TB":[97],"all":[99],"improved":[100],"significantly":[101],"(P0.05)":[102],"as":[103],"compared":[104],"with":[105],"NS":[106],"injection":[107],"group.The":[108],"1-":[109],"2-week":[111],"hepatocyte":[117,125,145],"transplantation":[118,126,146],"group":[119,127],"longer":[121],"than":[122],"free":[124],"(78.6%":[128],"vs":[129,135],"66.7":[130],"%":[131,134,137],",":[132],"42.9":[133],"25.0":[136],"respevtively,":[138],"P":[139],"0.01)":[140],".":[141],"Conclusion":[142],"Microencapsulated":[143],"xenogeneic":[144],"is":[147],"effective":[148],"treatment":[151],"AHF.":[153]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}