{"id":"https://openalex.org/W2385138017","doi":null,"title":"Vascular dysfunction in the offspring of AT1 receptor antibody-positive pregnant rats during high-salt diet.","display_name":"Vascular dysfunction in the offspring of AT1 receptor antibody-positive pregnant rats during high-salt diet.","publication_year":2011,"publication_date":"2011-04-25","ids":{"openalex":"https://openalex.org/W2385138017","mag":"2385138017","pmid":"https://pubmed.ncbi.nlm.nih.gov/21505730"},"language":"en","primary_location":{"id":"pmid:21505730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067712775","display_name":"Xinyuan Zhang","orcid":"https://orcid.org/0000-0002-3372-0798","observed_orcids":["https://orcid.org/0000-0002-3372-0798"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":["Department of Pathophysiology, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022298405","display_name":"Zhang Sl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su-Li Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083619853","display_name":"Xiong Hy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Yan Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039924968","display_name":"Du Yh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-Hui DU","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Quan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Quan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101577979","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0003-4034-4230","observed_orcids":["https://orcid.org/0000-0003-4034-4230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070813845","display_name":"Ma Xr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiu-Rui Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052791675","display_name":"Liu Hr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui-Rong Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"63","issue":"2","first_page":"149","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.46140000224113464,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.5659999847412109},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fetal-origins-of-adult-disease","display_name":"fetal origins of adult disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.902999997138977},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.9359999895095825},{"id":"https://openalex.org/keywords/norepinephrine-induced-contraction","display_name":"norepinephrine-induced contraction","score":0.8069999814033508},{"id":"https://openalex.org/keywords/acetylcholine-induced-relaxation","display_name":"acetylcholine-induced relaxation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hypertension-susceptibility","display_name":"hypertension susceptibility","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.9199540615081787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6566380262374878},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6184933185577393},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5891008377075195},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.5479181408882141},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4950527250766754},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.49315518140792847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4851747155189514},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45267605781555176},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.4478066861629486},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4365256428718567},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.4340227246284485},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.42631155252456665},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.36654233932495117},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32230764627456665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30045005679130554},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26810938119888306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005317","descriptor_name":"Fetal Growth Retardation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017673","descriptor_name":"Sodium Chloride, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017673","descriptor_name":"Sodium Chloride, Dietary","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D044140","descriptor_name":"Receptor, Angiotensin, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21505730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1966915255","https://openalex.org/W1971215727","https://openalex.org/W1992563074","https://openalex.org/W1993194232","https://openalex.org/W2015470285","https://openalex.org/W2036252770","https://openalex.org/W2045908881","https://openalex.org/W2051244860","https://openalex.org/W2064143839","https://openalex.org/W2074467897","https://openalex.org/W2088804755","https://openalex.org/W2089221056","https://openalex.org/W2098892892","https://openalex.org/W2132423208","https://openalex.org/W2138944514","https://openalex.org/W2140785684","https://openalex.org/W2143764193","https://openalex.org/W2155857736","https://openalex.org/W2161694484","https://openalex.org/W2163221788","https://openalex.org/W3003896705","https://openalex.org/W4254913758"],"related_works":["https://openalex.org/W4398165349","https://openalex.org/W1965946084","https://openalex.org/W1786375256","https://openalex.org/W1993900521","https://openalex.org/W2753343649","https://openalex.org/W2005539077","https://openalex.org/W3032353492","https://openalex.org/W4416416279","https://openalex.org/W128587317","https://openalex.org/W2032044261"],"abstract_inverted_index":{"Antibody":[0],"against":[1],"the":[2,14,40,73,122,128,140,169,215,221,240,252,258,301],"angiotensin":[3],"AT1":[4],"receptor":[5],"(AT1-Ab)":[6],"could":[7,49],"disturb":[8],"placental":[9],"development.":[10],"The":[11,60,199],"placenta":[12],"is":[13],"key":[15],"organ":[16],"between":[17,251],"mother":[18],"and":[19,28,95,150,209,284],"fetus.":[20],"Placental":[21],"damage":[22],"will":[23],"seriously":[24],"impair":[25],"fetal":[26,41],"growth":[27,35],"development":[29],"in":[30,72,125,184],"utero,":[31],"leading":[32],"to":[33,53,65,103,112,162,205,310],"intrauterine":[34],"restriction":[36],"(IUGR).":[37],"Based":[38],"on":[39],"origins":[42],"of":[43,76,120,217,249,268,303],"adult":[44,55,74],"disease":[45,58],"(FOAD)":[46],"hypothesis,":[47],"IUGR":[48],"increase":[50],"a":[51,176],"propensity":[52],"develop":[54],"onset":[56],"cardiovascular":[57],"(CVD).":[59],"present":[61],"study":[62],"was":[63,110,191,203,245],"designed":[64],"determine":[66],"whether":[67],"vascular":[68,200,207,311],"function":[69,208],"has":[70],"changed":[71],"offspring":[75,155,172,255,270,302],"AT1-Ab":[77,86],"positive":[78],"pregnant":[79,305],"rats.":[80],"Twenty":[81],"four":[82],"female":[83,129,141],"rats":[84,130,142,149,156,173,256,306],"(8-week-old,":[85],"negative)":[87],"were":[88,131,143,160,174],"randomly":[89],"divided":[90],"into":[91],"two":[92,170,253],"groups,":[93],"immunized":[94],"vehicle":[96,108,237],"groups.":[97],"Immunized":[98],"group":[99,109,154,238],"received":[100],"active":[101],"immunization":[102],"establish":[104],"AT1-Ab-positive":[105,304],"model,":[106],"while":[107,314],"subjected":[111],"Freund's":[113],"adjuvant":[114],"without":[115],"antigen.":[116],"After":[117],"8":[118],"weeks":[119,181],"immunization,":[121],"antibody":[123,218],"titers":[124,216],"sera":[126],"from":[127],"detected":[132,212],"by":[133,194,213],"enzyme-linked":[134],"immunosorbent":[135],"assay":[136],"(ELISA).":[137],"Then":[138,168],"all":[139],"mated":[144],"with":[145],"normal":[146],"Wistar":[147],"male":[148],"became":[151],"pregnant.":[152],"Immunized/vehicle":[153],"(I":[157],"offspring/V":[158],"offspring)":[159,283],"raised":[161],"40-week-old":[163],"under":[164,275,288],"standard":[165],"chow":[166,185],"feeding.":[167],"groups'":[171,254],"given":[175],"high-salt":[177,259,317],"diet":[178,260],"for":[179],"12":[180],"(4%":[182],"NaCl":[183],"feeding).":[186],"Systolic":[187],"blood":[188,196],"pressure":[189,197],"(SBP)":[190],"measured":[192],"dynamically":[193],"noninvasive":[195],"system.":[198],"ring":[201],"experiment":[202],"performed":[204],"detect":[206],"reactivity.":[210],"As":[211],"ELISA,":[214],"peaked":[219],"at":[220,239],"8th":[222],"week":[223],"(OD":[224],"values:":[225],"2.75":[226],"\u00b1":[227,231],"0.08":[228],"vs":[229,236,281,294],"0.33":[230],"0.01,":[232],"P":[233],"<":[234,279,292],"0.01":[235,280],"same":[241],"time":[242],"point).":[243],"There":[244],"no":[246],"significant":[247],"difference":[248],"SBP":[250],"during":[257],"(P":[261,278,291],">":[262],"0.05).":[263],"Isolated":[264],"thoracic":[265],"aortic":[266],"rings":[267],"I":[269],"had":[271],"significantly":[272,285],"decreased":[273,286],"constriction":[274],"norepinephrine":[276],"treatment":[277,290],"V":[282,295],"dilation":[287],"acetylcholine":[289],"0.05":[293],"offspring).":[296],"These":[297],"results":[298],"suggest":[299],"that":[300],"are":[307],"more":[308],"susceptible":[309],"functional":[312],"abnormality":[313],"being":[315],"fed":[316],"diet.":[318]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
