{"id":"https://openalex.org/W2383487941","doi":null,"title":"The feasibility of using radionuclide-labeled drugs in human mass balance study","display_name":"The feasibility of using radionuclide-labeled drugs in human mass balance study","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2383487941","mag":"2383487941"},"language":"en","primary_location":{"id":"mag:2383487941","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GLYZ201310026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764396500","display_name":"The Chinese Journal of Clinical Pharmacology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Chinese Journal of Clinical Pharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012622185","display_name":"XU Jun-y","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"XU Jun-y","raw_affiliation_strings":["Department of Nuclear Medicine, Peking University First Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Peking University First Hospital","institution_ids":["https://openalex.org/I4210130930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012622185"],"corresponding_institution_ids":["https://openalex.org/I4210130930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27929588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6592000126838684,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.2273000031709671,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiolabeled-drug","display_name":"radiolabeled drug","score":0.8999999761581421},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.843999981880188},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.9380000233650208},{"id":"https://openalex.org/keywords/adme","display_name":"ADME","score":0.5109999775886536},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.4309999942779541},{"id":"https://openalex.org/keywords/regulatory-feasibility","display_name":"regulatory feasibility","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C69366308","wikidata":"https://www.wikidata.org/wiki/Q2272286","display_name":"ADME","level":3,"score":0.7705477476119995},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5474002957344055},{"id":"https://openalex.org/C2777363581","wikidata":"https://www.wikidata.org/wiki/Q15098235","display_name":"Harm","level":2,"score":0.5035077929496765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4807712435722351},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.452846884727478},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4437202513217926},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.42745622992515564},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.41427692770957947},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3950234055519104},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.10356280207633972},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.08392226696014404},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2383487941","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GLYZ201310026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764396500","display_name":"The Chinese Journal of Clinical Pharmacology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800687","host_organization_name":"Chinese Pharmaceutical Association","host_organization_lineage":["https://openalex.org/P4320800687"],"host_organization_lineage_names":["Chinese Pharmaceutical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Chinese Journal of Clinical Pharmacology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4294783759","https://openalex.org/W2408277066","https://openalex.org/W7171286985","https://openalex.org/W7139929871","https://openalex.org/W4242146960","https://openalex.org/W4415648407","https://openalex.org/W4214543699","https://openalex.org/W4390796717","https://openalex.org/W2765228153","https://openalex.org/W4296204938"],"abstract_inverted_index":{"Mass":[0],"balance":[1,102],"study,in":[2],"which":[3],"the":[4,52,57,63,73,80,120,137,140,146,159],"radionuclide":[5],"labeling":[6],"technique":[7],"can":[8],"be":[9,67,94],"used":[10,27],"to":[11,31,36,42,50,93,96,136],"obtain":[12,32],"more":[13,98],"detailed":[14,99],"pharmacokinetic":[15],"data,is":[16],"very":[17],"important":[18],"for":[19,108],"drug":[20,82,90],"research":[21],"and":[22,39,54,114,125,133,142],"development.The":[23],"radioactive":[24],"drugs":[25],"are":[26,91],"in":[28,69,111,119,164,168],"human":[29,74,151],"subjects":[30],"basic":[33],"information":[34],"relating":[35],"metabolism,human":[37],"physiology,pathophysiology":[38],"biochemistry,rather":[40],"than":[41],"accomplish":[43],"immediate":[44],"therapeutic":[45],"or":[46,49],"diagnostic":[47],"purposes":[48],"determine":[51],"safety":[53,64],"effectiveness":[55],"of":[56,79,122,139,158,161],"drug.The":[58],"FDA":[59],"guidance":[60],"recommends":[61],"that":[62,118],"assessment":[65],"should":[66],"considered":[68,92],"nonclinical":[70],"studies":[71,87],"if":[72],"metabolites":[75],"exposure":[76,84],"exceeds":[77],"10%":[78],"parent":[81],"systemic":[83],"at":[85],"steady-state.ADME":[86],"with":[88],"radiolabeled":[89],"able":[95],"provide":[97],"metabolism":[100],"data.Mass":[101],"study":[103],"had":[104],"been":[105],"carried":[106],"out":[107],"40":[109],"years":[110],"foreign":[112],"countries":[113],"their":[115],"experiences":[116],"showed":[117],"prerequisite":[121],"reasonable":[123],"design":[124],"standard":[126],"operation,the":[127],"radiation":[128],"will":[129],"not":[130],"harm":[131],"investigators":[132],"subjects.In":[134],"China,due":[135],"limitations":[138],"laws":[141],"regulations,as":[143],"well":[144],"as":[145],"ethical":[147],"factors,there":[148],"is":[149,166],"no":[150],"test":[152],"instance":[153],"yet":[154],"so":[155],"far.However,the":[156],"feasibility":[157],"implementation":[160],"this":[162,169],"technology":[163],"China":[165],"discussed":[167],"article.":[170]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
