{"id":"https://openalex.org/W2383472541","doi":null,"title":"Protective effects of reactive oxygen species against arsenic-induced DNA damage in human cells","display_name":"Protective effects of reactive oxygen species against arsenic-induced DNA damage in human cells","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2383472541","mag":"2383472541"},"language":"en","primary_location":{"id":"mag:2383472541","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZDFB200104004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506097","display_name":"Chin J Endemiol","issn_l":"1000-4955","issn":["1000-4955"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Jouranl of Endemiology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101823789","display_name":"Dasheng Li","orcid":"https://orcid.org/0000-0002-5071-5739","observed_orcids":["https://orcid.org/0000-0002-5071-5739"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dasheng Li","raw_affiliation_strings":["Kanehisa Morimoto, Tatsuya Takeshita,et al"],"raw_orcid":"https://orcid.org/0000-0002-5071-5739","affiliations":[{"raw_affiliation_string":"Kanehisa Morimoto, Tatsuya Takeshita,et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101823789"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.23227542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10710","display_name":"Arsenic contamination and mitigation","score":0.1234000027179718,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic","display_name":"arsenic","score":0.9139999747276306},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.753000020980835},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9010000228881836},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.7739999890327454},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/human-lymphocytes","display_name":"human lymphocytes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.8489421606063843},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.8163443207740784},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7637421488761902},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7509424686431885},{"id":"https://openalex.org/C2778903051","wikidata":"https://www.wikidata.org/wiki/Q5630035","display_name":"HL60","level":3,"score":0.6902076601982117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6386317014694214},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.6013814210891724},{"id":"https://openalex.org/C2778452553","wikidata":"https://www.wikidata.org/wiki/Q407927","display_name":"Dimethyl sulfoxide","level":2,"score":0.5789626836776733},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5520808100700378},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5279091000556946},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.4872111678123474},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4846861660480499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47401338815689087},{"id":"https://openalex.org/C502230775","wikidata":"https://www.wikidata.org/wiki/Q871","display_name":"Arsenic","level":2,"score":0.4517842233181},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4492564797401428},{"id":"https://openalex.org/C172507514","wikidata":"https://www.wikidata.org/wiki/Q730249","display_name":"Arsenic toxicity","level":3,"score":0.44596779346466064},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4342014491558075},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2914586067199707},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2765701413154602},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23841562867164612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23205256462097168},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17332902550697327},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2383472541","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZDFB200104004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506097","display_name":"Chin J Endemiol","issn_l":"1000-4955","issn":["1000-4955"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Jouranl of Endemiology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972882006","https://openalex.org/W4243944514","https://openalex.org/W1966398962","https://openalex.org/W7096671953","https://openalex.org/W7101023421","https://openalex.org/W2053658205","https://openalex.org/W1973041015","https://openalex.org/W2060055511","https://openalex.org/W3023219947","https://openalex.org/W2162088045"],"abstract_inverted_index":{"Objective":[0],"To":[1],"elucidate":[2],"that":[3,100],"arsenic":[4,12],"induces":[5,105],"oxidative":[6],"DNA":[7,54,67,89,111],"damage.Methods":[8],"The":[9],"genotoxicity":[10],"of":[11,30,34,44,77,110],"in":[13,26,56,71,92,113,131],"human":[14,59,72,114],"cells":[15,115],"was":[16,69],"comparatively":[17],"studied":[18],"with":[19,28],"single":[20],"cell":[21,62],"gel":[22],"electrophoresis":[23],"(SCGE)":[24],"assay":[25],"combination":[27],"observation":[29],"the":[31,42,75,87],"protective":[32],"effects":[33],"dimethyl":[35],"sulfoxide":[36],"(DMSO)":[37],"and":[38,83,95,107,126],"catalase.Results":[39],"Arsenic,":[40],"at":[41,74],"concentration":[43,76],"2.4":[45],"\u03bcmol":[46],"by":[47],"coincubation":[48],"for":[49],"24":[50],"hours,":[51],"significantly":[52,85],"induced":[53],"damage":[55,68,112],"HL60,":[57],"a":[58,132],"promyelocytic":[60],"leukemia":[61],"line.":[63],"In":[64],"contrast,":[65],"significant":[66],"found":[70],"lymphocytes":[73],"4.8":[78],"\u03bcM":[79],"or":[80],"above.":[81],"DMSO":[82],"catalase":[84],"reduced":[86],"arsenic-induced":[88],"strand":[90],"breaks":[91],"both":[93],"HL60":[94],"lymphocytes.Conclusions":[96],"Our":[97],"data":[98],"indicate":[99],"arsenic,":[101],"within":[102],"micromolar":[103],"concentrations,":[104],"typical":[106],"various":[108],"extent":[109],"via":[116],"reactive":[117],"oxygen":[118],"species,":[119],"chiefly":[120],"hydrogen":[121],"peroxide":[122],"(H":[123],"2O":[124],"2)":[125],"superoxide":[127],"(O":[128],"2":[129],"-),":[130],"dose-dependent":[133],"manner.":[134]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
