{"id":"https://openalex.org/W2383321","doi":null,"title":"Human ceruloplasmin and neurotransmitters: complex stabilization and crystallization","display_name":"Human ceruloplasmin and neurotransmitters: complex stabilization and crystallization","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2383321","mag":"2383321"},"language":"en","primary_location":{"id":"pmh:oai:run.unl.pt:10362/10853","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/10853","pdf_url":"https://run.unl.pt/bitstreams/abacd345-7a1b-493e-ba1f-3cccecfd5c9f/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://run.unl.pt/bitstreams/abacd345-7a1b-493e-ba1f-3cccecfd5c9f/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041843387","display_name":"Daniela Moutinho","orcid":"https://orcid.org/0000-0002-8554-4765","observed_orcids":["https://orcid.org/0000-0002-8554-4765"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniela Moutinho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8554-4765","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041843387"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10464","display_name":"Crystal structures of chemical compounds","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-ligand-complex","display_name":"protein-ligand complex","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"protein crystallization","score":0.7620000243186951},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.9390000104904175},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/protein-stabilization","display_name":"protein stabilization","score":0.6520000100135803},{"id":"https://openalex.org/keywords/protein-solubility","display_name":"protein solubility","score":0.7260000109672546},{"id":"https://openalex.org/keywords/copper-metabolism","display_name":"copper metabolism","score":0.3700000047683716},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7459999918937683},{"id":"https://openalex.org/keywords/crystal-soaking","display_name":"crystal soaking","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.7994290590286255},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.6444761753082275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3852870464324951},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3627837896347046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29576659202575684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.238503098487854},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/10853","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/10853","pdf_url":"https://run.unl.pt/bitstreams/abacd345-7a1b-493e-ba1f-3cccecfd5c9f/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2383321","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/10853/1/Moutinho_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/10853","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/10853","pdf_url":"https://run.unl.pt/bitstreams/abacd345-7a1b-493e-ba1f-3cccecfd5c9f/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2383321.pdf","grobid_xml":"https://content.openalex.org/works/W2383321.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W937394320","https://openalex.org/W1992232455","https://openalex.org/W2007048586","https://openalex.org/W2019279182","https://openalex.org/W2029443758","https://openalex.org/W2073283352","https://openalex.org/W2075182910","https://openalex.org/W2086681228","https://openalex.org/W2092807733","https://openalex.org/W2158115535"],"related_works":["https://openalex.org/W2244487226","https://openalex.org/W7216792230","https://openalex.org/W153030471","https://openalex.org/W610857606","https://openalex.org/W178982770","https://openalex.org/W629094801","https://openalex.org/W7062176035","https://openalex.org/W7025484096","https://openalex.org/W2409536186","https://openalex.org/W155762358"],"abstract_inverted_index":{"Human":[0],"ceruloplasmin":[1],"(hCp)":[2],"is":[3,63,96,122,126],"the":[4,8,17,50,57,82,87,106,127,206,225,248,259],"molecular":[5],"linker":[6],"between":[7],"copper":[9],"and":[10,13,39,59,91,108,159,183,188,274],"iron":[11],"metabolism":[12],"its":[14,176],"importance":[15],"in":[16,25,56,70,105,163,171,194,211,252],"homeostasis":[18,94],"of":[19,52,84,89,110,116,161,234,244,258],"human":[20],"body":[21],"has":[22,32,46,137],"been":[23],"implied":[24,104],"some":[26,138],"neurological":[27],"diseases.":[28],"This":[29,125],"plasma":[30],"cuproenzyme":[31],"ferroxidase":[33],"activity,":[34],"oxidizing":[35],"Fe2+":[36],"to":[37,65,98,131,153,173,229,255],"Fe3+":[38],"incorporating":[40],"it":[41,62,95],"into":[42],"apotransferrin.":[43],"hCp":[44,156,181,204,235,245],"also":[45],"aminoxidase":[47],"activity":[48],"regulating":[49],"levels":[51],"amine":[53],"stress":[54],"hormones":[55],"bloodstream":[58],"brain.":[60],"Thus,":[61],"thought":[64],"have":[66],"an":[67,253],"important":[68],"role":[69,83],"neurodegenerative":[71],"diseases":[72],"such":[73],"as":[74,140],"Alzheimer\u2019s":[75],"or":[76,169],"Parkinson\u2019s.":[77],"To":[78,179],"know":[79,99],"more":[80],"about":[81],"cerulopalsmin":[85],"on":[86,92],"oxidation":[88],"neurotransmitters":[90,237,249],"brain":[93],"essential":[97],"which":[100],"protein":[101,144],"residues":[102],"are":[103],"binding":[107],"stabilization":[109,182],"these":[111],"neurotransmitters.":[112],"The":[113],"primary":[114],"source":[115],"structural":[117,275],"information":[118],"for":[119,197,201,266],"protein-ligand":[120],"complexes":[121],"X-ray":[123],"crystallography.":[124],"most":[128],"successful":[129],"method":[130],"determine":[132,175],"macromolecular":[133],"3D":[134],"structures":[135],"but":[136],"limitations":[139],"obtaining":[141],"good":[142],"diffracting":[143,157],"crystals.":[145],"In":[146],"this":[147],"study":[148],"several":[149,214,226],"attempts":[150],"were":[151,192,224,264],"made":[152],"achieve":[154],"better":[155,199],"crystals":[158,160,246,257,263],"hcp":[162],"complex":[164],"with":[165,213,236,240,247],"dopamine,":[166],"L-dopa,":[167],"epinephrine":[168],"serotonin":[170],"order":[172],"further":[174,279],"tridimensional":[177],"structure.":[178],"improve":[180,230],"solubility,":[184],"differential":[185],"scanning":[186],"fluorimetry":[187],"dynamic":[189],"light":[190],"scattering":[191],"used":[193,210,228],"a":[195,198],"search":[196],"buffer":[200],"crystallization.":[202],"For":[203],"crystallization":[205,218],"vapour-diffusion":[207],"technique":[208],"was":[209,238,250],"combination":[212],"other":[215],"methods.":[216],"Commercial":[217],"screens,":[219],"crystal":[220,231],"seeding,":[221],"additives,":[222],"crosslinking":[223],"methods":[227],"diffraction.":[232],"Co-crystallization":[233],"performed":[239,251],"no":[241],"success.":[242],"Soaking":[243],"attempt":[254],"get":[256],"hCpneurotransmitter":[260],"complexes.":[261],"All":[262],"sent":[265],"analysis":[267],"at":[268],"European":[269],"Synchrotron":[270],"Radiation":[271],"Facility":[272],"(ESRF)":[273],"data":[276],"will":[277],"be":[278],"processed.":[280]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
