{"id":"https://openalex.org/W2383099817","doi":null,"title":"Microglia and their roles in response to injury of the central nervous system","display_name":"Microglia and their roles in response to injury of the central nervous system","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2383099817","mag":"2383099817"},"language":"en","primary_location":{"id":"mag:2383099817","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB201204020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101046013","display_name":"Yue Jia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yue Jia","raw_affiliation_strings":["reviewing,WANG Han-dong checking"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"reviewing,WANG Han-dong checking","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101046013"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.29659643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.925000011920929},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.949999988079071},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nerve-regeneration","display_name":"nerve regeneration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.722000002861023},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7400000095367432},{"id":"https://openalex.org/keywords/reactive-nitrogen-intermediates","display_name":"reactive nitrogen intermediates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9456179141998291},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.660788893699646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5977883338928223},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5832139849662781},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5601612329483032},{"id":"https://openalex.org/C2777700362","wikidata":"https://www.wikidata.org/wiki/Q107647","display_name":"Phagocyte","level":3,"score":0.5557368397712708},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5481600165367126},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.47613289952278137},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4561544954776764},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42699605226516724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3620096743106842},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3368653655052185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07676306366920471},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2383099817","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB201204020.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2109759840","https://openalex.org/W2131939356","https://openalex.org/W4233168013","https://openalex.org/W2119895789","https://openalex.org/W2288805393","https://openalex.org/W2038438278","https://openalex.org/W7098887490","https://openalex.org/W4232122345","https://openalex.org/W2993827606","https://openalex.org/W199327114"],"abstract_inverted_index":{"Microglia":[0],"are":[1,15,49],"cells":[2,20,52],"of":[3,26,67,103,113,126,143,157],"the":[4,11,16,40,97,111,155],"mononuclear-phagocyte":[5],"lineage":[6],"and":[7,42,53,61,78,94],"ubiquitously":[8],"spread":[9],"in":[10,21,32,39,58,161],"central":[12],"nervous":[13],"system(CNS).Functionally,microglia":[14],"principal":[17],"immune":[18,68,76],"effector":[19],"CNS.The":[22],"most":[23],"characteristic":[24],"property":[25],"microglia":[27,48,80,104,147],"is":[28,108,129],"their":[29,43],"swift":[30],"activation":[31,140],"response":[33],"to":[34,99],"even":[35],"minor":[36],"pathological":[37],"changes":[38],"CNS":[41,162],"capacity":[44,74],"for":[45,75,131,154],"site-directed":[46],"phagocytosis.Activated":[47],"mainly":[50],"scavenger":[51],"perform":[54],"various":[55],"other":[56],"functions":[57],"tissue":[59,88,100],"repair":[60,89],"neural":[62],"regeneration.They":[63],"form":[64],"a":[65,73],"network":[66],"alert":[69],"resident":[70],"macrophages":[71,107],"with":[72,138],"surveillance":[77],"control.Activated":[79],"can":[81],"destroy":[82],"invading":[83],"micro-organisms,remove":[84],"potentially":[85],"deleterious":[86],"debris,promote":[87],"by":[90,110,146],"secreting":[91],"growth":[92],"factors":[93],"thus":[95,149],"facilitate":[96],"return":[98],"homeostasis.Meanwhile,the":[101],"differentiation":[102],"into":[105],"brain":[106],"accompanied":[109],"release":[112],"several":[114],"secretory":[115],"products,such":[116],"as":[117],"proteinases,cytokines,reactive":[118],"oxygen":[119],"intermediates,and":[120],"reactive":[121],"nitrogen":[122],"intermediates.The":[123],"elevated":[124],"expression":[125],"such":[127],"molecules":[128],"responsible":[130],"increased":[132],"secondary":[133],"neuronal":[134,158],"death":[135,160],"after":[136],"injury.Interference":[137],"microglial":[139],"or":[141],"productions":[142],"cytotoxic":[144],"metabolites":[145],"may":[148],"offer":[150],"new":[151],"therapeutic":[152],"opportunities":[153],"prevention":[156],"cell":[159],"disease.":[163]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
