{"id":"https://openalex.org/W23828251","doi":null,"title":"The Effect of a six month low-carbohydrate diet on the biomarkers of bone health in pre- and post-menopausal women: a randomised control crossover trial","display_name":"The Effect of a six month low-carbohydrate diet on the biomarkers of bone health in pre- and post-menopausal women: a randomised control crossover trial","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W23828251","mag":"23828251"},"language":"en","primary_location":{"id":"pmh:oai:repository.wit.ie:3159","doi":null,"is_oa":false,"landing_page_url":"https://repository.wit.ie/3159/1/Final%20Thesis%20Dec%2012th.pdf","pdf_url":"https://repository.wit.ie/3159/1/Final%20Thesis%20Dec%2012th.pdf","source":{"id":"https://openalex.org/S4377196138","display_name":"SETU Waterford Libraries - Open Access Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046416526","display_name":"Doreen Fitzmaurice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fitzmaurice, Doreen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Doyle, Lorna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doyle, Lorna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046416526"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-carbohydrate-diet","display_name":"low-carbohydrate diet","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-health","display_name":"bone health","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.699999988079071},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7450000047683716},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8809999823570251},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.7210000157356262},{"id":"https://openalex.org/keywords/urinary-calcium","display_name":"urinary calcium","score":0.5429999828338623},{"id":"https://openalex.org/keywords/urinary-magnesium","display_name":"urinary magnesium","score":0.3059999942779541},{"id":"https://openalex.org/keywords/urinary-potassium","display_name":"urinary potassium","score":0.6859999895095825},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ntx","display_name":"NTX","score":0.8870000243186951},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6610000133514404},{"id":"https://openalex.org/keywords/dietary-macronutrients","display_name":"dietary macronutrients","score":0.6309999823570251},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5400000214576721},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.4860000014305115},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.460999995470047},{"id":"https://openalex.org/keywords/calcium-intake","display_name":"calcium intake","score":0.550000011920929},{"id":"https://openalex.org/keywords/sodium-intake","display_name":"sodium intake","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7525741457939148},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5515913963317871},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.5088046193122864},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47937634587287903},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.4772067964076996},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.476440966129303},{"id":"https://openalex.org/C2778976249","wikidata":"https://www.wikidata.org/wiki/Q17005820","display_name":"Bone health","level":4,"score":0.43203204870224},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.42798474431037903},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37661147117614746},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.37547072768211365},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.35629355907440186},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.28532254695892334},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.28037023544311523},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.17838671803474426},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.wit.ie:3159","doi":null,"is_oa":false,"landing_page_url":"https://repository.wit.ie/3159/1/Final%20Thesis%20Dec%2012th.pdf","pdf_url":"https://repository.wit.ie/3159/1/Final%20Thesis%20Dec%2012th.pdf","source":{"id":"https://openalex.org/S4377196138","display_name":"SETU Waterford Libraries - Open Access Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":175,"referenced_works":["https://openalex.org/W21231275","https://openalex.org/W83348053","https://openalex.org/W104095340","https://openalex.org/W117983342","https://openalex.org/W187931946","https://openalex.org/W198489678","https://openalex.org/W206271158","https://openalex.org/W626644052","https://openalex.org/W1500518888","https://openalex.org/W1507351190","https://openalex.org/W1513117029","https://openalex.org/W1534479899","https://openalex.org/W1540990557","https://openalex.org/W1542176248","https://openalex.org/W1580879347","https://openalex.org/W1786583825","https://openalex.org/W1890354996","https://openalex.org/W1891035597","https://openalex.org/W1907416804","https://openalex.org/W1912405252","https://openalex.org/W1912594399","https://openalex.org/W1919759535","https://openalex.org/W1920253561","https://openalex.org/W1950129067","https://openalex.org/W1965605044","https://openalex.org/W1965864361","https://openalex.org/W1967309168","https://openalex.org/W1972864074","https://openalex.org/W1975393404","https://openalex.org/W1979981434","https://openalex.org/W1982403156","https://openalex.org/W1986079069","https://openalex.org/W1988751617","https://openalex.org/W1991184745","https://openalex.org/W1995417183","https://openalex.org/W1995989871","https://openalex.org/W1997438219","https://openalex.org/W1998703445","https://openalex.org/W2001948451","https://openalex.org/W2003998239","https://openalex.org/W2004728560","https://openalex.org/W2005220269","https://openalex.org/W2005779589","https://openalex.org/W2006202722","https://openalex.org/W2007078240","https://openalex.org/W2008108291","https://openalex.org/W2013084866","https://openalex.org/W2013631553","https://openalex.org/W2015082391","https://openalex.org/W2017305275","https://openalex.org/W2018754780","https://openalex.org/W2018900615","https://openalex.org/W2018998710","https://openalex.org/W2020209491","https://openalex.org/W2021063196","https://openalex.org/W2022322844","https://openalex.org/W2024068251","https://openalex.org/W2024753111","https://openalex.org/W2035364124","https://openalex.org/W2037333519","https://openalex.org/W2040801983","https://openalex.org/W2041599197","https://openalex.org/W2042548863","https://openalex.org/W2042855443","https://openalex.org/W2046861848","https://openalex.org/W2046906493","https://openalex.org/W2051772576","https://openalex.org/W2053322674","https://openalex.org/W2054311522","https://openalex.org/W2054708872","https://openalex.org/W2056500794","https://openalex.org/W2058832432","https://openalex.org/W2060415047","https://openalex.org/W2060654590","https://openalex.org/W2060736241","https://openalex.org/W2062770407","https://openalex.org/W2064704120","https://openalex.org/W2068095019","https://openalex.org/W2068947159","https://openalex.org/W2072144889","https://openalex.org/W2074497389","https://openalex.org/W2074840086","https://openalex.org/W2075484386","https://openalex.org/W2077256934","https://openalex.org/W2083033643","https://openalex.org/W2084248319","https://openalex.org/W2087198098","https://openalex.org/W2088091529","https://openalex.org/W2088951374","https://openalex.org/W2092292715","https://openalex.org/W2092892976","https://openalex.org/W2092901735","https://openalex.org/W2094795339","https://openalex.org/W2096822954","https://openalex.org/W2100023355","https://openalex.org/W2102430011","https://openalex.org/W2103058568","https://openalex.org/W2103596372","https://openalex.org/W2103862350","https://openalex.org/W2103916483","https://openalex.org/W2104604816","https://openalex.org/W2105709324","https://openalex.org/W2105888529","https://openalex.org/W2106499145","https://openalex.org/W2107290206","https://openalex.org/W2107773516","https://openalex.org/W2108881204","https://openalex.org/W2109022664","https://openalex.org/W2109749440","https://openalex.org/W2113561145","https://openalex.org/W2113756292","https://openalex.org/W2115307655","https://openalex.org/W2115550020","https://openalex.org/W2115896958","https://openalex.org/W2116433329","https://openalex.org/W2116469631","https://openalex.org/W2116513447","https://openalex.org/W2119374420","https://openalex.org/W2119714551","https://openalex.org/W2119739932","https://openalex.org/W2120298824","https://openalex.org/W2120417182","https://openalex.org/W2122147292","https://openalex.org/W2124070987","https://openalex.org/W2124388416","https://openalex.org/W2126151621","https://openalex.org/W2127033523","https://openalex.org/W2128977360","https://openalex.org/W2130544065","https://openalex.org/W2131059541","https://openalex.org/W2131188896","https://openalex.org/W2132157492","https://openalex.org/W2132493841","https://openalex.org/W2133333193","https://openalex.org/W2133514604","https://openalex.org/W2134315295","https://openalex.org/W2135806535","https://openalex.org/W2136203132","https://openalex.org/W2136223041","https://openalex.org/W2138265539","https://openalex.org/W2139462080","https://openalex.org/W2140156866","https://openalex.org/W2140791028","https://openalex.org/W2143434254","https://openalex.org/W2144376568","https://openalex.org/W2145538642","https://openalex.org/W2146463166","https://openalex.org/W2148140834","https://openalex.org/W2151771709","https://openalex.org/W2153218339","https://openalex.org/W2153324978","https://openalex.org/W2156743436","https://openalex.org/W2156849867","https://openalex.org/W2158830391","https://openalex.org/W2159223439","https://openalex.org/W2160858945","https://openalex.org/W2160974120","https://openalex.org/W2161732392","https://openalex.org/W2165340329","https://openalex.org/W2165526796","https://openalex.org/W2166044131","https://openalex.org/W2167309544","https://openalex.org/W2167366583","https://openalex.org/W2168584580","https://openalex.org/W2169936359","https://openalex.org/W2170080359","https://openalex.org/W2170259364","https://openalex.org/W2170373716","https://openalex.org/W2185370485","https://openalex.org/W2302051883","https://openalex.org/W2398575778","https://openalex.org/W2562156993","https://openalex.org/W2798497722","https://openalex.org/W2993817728","https://openalex.org/W6908023797"],"related_works":["https://openalex.org/W2145395127","https://openalex.org/W2605952295","https://openalex.org/W2587053216","https://openalex.org/W2127033523","https://openalex.org/W2299741731","https://openalex.org/W2058832432","https://openalex.org/W2506521120","https://openalex.org/W2321078545","https://openalex.org/W3015551152","https://openalex.org/W7135445602"],"abstract_inverted_index":{"With":[0],"increasing":[1],"levels":[2],"of":[3,22,43,63,71,81,144,272],"obesity,":[4],"the":[5,69,121,185,259,263,273,279,293],"low-carbohydrate":[6,73,109,186,260,274,323],"diet":[7,26,45,74,110,187,275,296,324,360],"has":[8,27],"again":[9],"become":[10],"popular":[11],"as":[12],"a":[13,23,72,106,156,190,214,322],"weight":[14,18,218],"loss":[15,19,319],"method.":[16],"While":[17],"through":[20],"consumption":[21],"low":[24,294],"carbohydrate":[25,199,295],"been":[28],"well":[29],"researched,":[30],"there":[31],"is":[32,58],"contradictory":[33],"evidence":[34],"regarding":[35],"its":[36],"effect":[37,42,70],"on":[38,46,79,180],"bone":[39,47,82,145,337,347,356,364],"health.":[40],"The":[41,61],"this":[44,64,351,359],"health":[48,83,338,365],"for":[49,112,125,142,167],"greater":[50],"than":[51],"12":[52,181,270,298],"weeks":[53,78,271,299],"and":[54,86,94,129,138,147,155,169,198,237,251,290,300,305],"in":[55,84,189,193,217,258,287,302,313,328,350],"menopausal":[56],"women":[57],"relatively":[59],"unknown.":[60],"aim":[62],"study":[65,352],"was":[66,153,165,178,213],"to":[67,105,120,321,336,344],"assess":[68],"consumed":[75],"over":[76,119,269,278,297,366],"24":[77,96,113,126,280],"biomarkers":[80,143],"pre-":[85],"postmenopausal":[87],"females.":[88],"Following":[89],"ethical":[90],"approval,":[91],"informed":[92],"consent":[93],"screening,":[95],"subjects":[97,182],"(13":[98],"pre-menopausal;":[99],"11":[100],"postmenopausal)":[101],"were":[102,116,140,175,256,284,309],"randomly":[103],"assigned":[104],"control":[107],"or":[108],"group":[111],"weeks.":[114,127],"Subjects":[115],"then":[117],"crossed":[118],"alternative":[122],"dietary":[123],"regimen":[124],"Blood":[128],"urine":[130],"samples":[131],"taken":[132],"at":[133],"week":[134,281],"12,":[135],"24,":[136],"36":[137],"48":[139],"analysed":[141,161,166],"resorption":[146,348],"formation":[148,357],"using":[149,162],"ELIZA.":[150],"Urine":[151],"pH":[152],"measured":[154],"3":[157],"day":[158],"food":[159],"diary":[160],"CompEat\u2122.":[163],"Data":[164],"treatment":[168],"carryover":[170,173],"effects.":[171],"Where":[172],"effects":[174],"evident":[176],"analysis":[177],"completed":[179],"only.":[183],"Consuming":[184],"resulted":[188],"significant":[191,215,285,311,326],"decrease":[192],"energy":[194],"(P":[195,200,209,219,224,230,234,239,244,248,253],"=":[196,201,210,220,225,231,235,240,245,249,254],"0.017)":[197],"0.001)":[202],"but":[203,276,339],"protein":[204],"intake":[205,330],"did":[206],"not":[207,277],"change":[208],"0.264).":[211],"There":[212,283,308],"reduction":[216],"0.000),":[221,226],"waist":[222],"circumference":[223],"diastolic":[227],"blood":[228],"pressure":[229],"0.021),":[232],"K":[233],"0.047)":[236],"Mg":[238],"0.005).":[241],"Increased":[242,346],"PRAL":[243],"0.004),":[246],"NTx":[247],"0.019)":[250],"IGF-1":[252],"0.043)":[255],"observed":[257,349],"period":[261],"versus":[262],"control.":[264],"Several":[265],"other":[266,315,340],"parameters":[267,316],"changed":[268],"period.":[282],"decreases":[286],"fibre,":[288],"Ca":[289],"Na":[291],"during":[292],"increases":[301],"vitamin":[303],"D":[304],"urinary":[306],"Ca.":[307],"no":[310],"differences":[312],"any":[314],"measured.":[317],"Weight":[318],"due":[320],"caused":[325],"changes":[327],"nutrient":[329],"with":[331],"some":[332],"aspects":[333,341],"being":[334],"conducive":[335],"perhaps":[342],"detrimental":[343],"bone.":[345],"without":[353],"concomitant":[354],"increased":[355],"suggests":[358],"could":[361],"cause":[362],"poor":[363],"time.":[367]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
