{"id":"https://openalex.org/W2381990493","doi":"https://doi.org/10.2310/6650.2005.00006.329","title":"330 ORAL ALKALI IMPROVES INDICES OF INCREASED CARDIOVASCULAR RISK IN CHRONIC KIDNEY DISEASE ASSOCIATED WITH PRIMARY HYPERTENSION","display_name":"330 ORAL ALKALI IMPROVES INDICES OF INCREASED CARDIOVASCULAR RISK IN CHRONIC KIDNEY DISEASE ASSOCIATED WITH PRIMARY HYPERTENSION","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2381990493","doi":"https://doi.org/10.2310/6650.2005.00006.329","mag":"2381990493"},"language":"en","primary_location":{"id":"doi:10.2310/6650.2005.00006.329","doi":"https://doi.org/10.2310/6650.2005.00006.329","is_oa":false,"landing_page_url":"https://doi.org/10.2310/6650.2005.00006.329","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. Khanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Khanna","raw_affiliation_strings":["Physiology, and Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, and Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029844807","display_name":"Jane M. Simoni","orcid":"https://orcid.org/0000-0002-8711-1576","observed_orcids":["https://orcid.org/0000-0002-8711-1576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Simoni","raw_affiliation_strings":["Physiology, and Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, and Surgery","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019935894","display_name":"Donald E. Wesson","orcid":"https://orcid.org/0009-0007-7952-7401","observed_orcids":["https://orcid.org/0009-0007-7952-7401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. E. Wesson","raw_affiliation_strings":["Physiology, and Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, and Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30753906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"1","first_page":"S312.1","last_page":"S312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.2280000001192093,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-citrate","display_name":"sodium citrate","score":0.9580000042915344},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9789999723434448},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8539999723434448},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.8460000157356262},{"id":"https://openalex.org/keywords/serum-bicarbonate","display_name":"serum bicarbonate","score":0.6119999885559082},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.824999988079071},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.42899999022483826},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.44600000977516174},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.5070000290870667},{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":0.38600000739097595},{"id":"https://openalex.org/keywords/albumin-creatinine-ratio","display_name":"albumin-creatinine ratio","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.806836724281311},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.793170690536499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7024806141853333},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6440141201019287},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5912542939186096},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5677065253257751},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48917391896247864},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4522347152233124},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4376704692840576},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.41581130027770996},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.39009594917297363}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2310/6650.2005.00006.329","doi":"https://doi.org/10.2310/6650.2005.00006.329","is_oa":false,"landing_page_url":"https://doi.org/10.2310/6650.2005.00006.329","pdf_url":null,"source":{"id":"https://openalex.org/S104415515","display_name":"Journal of Investigative Medicine","issn_l":"1081-5589","issn":["1081-5589","1708-8267"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378217332","https://openalex.org/W2375381345","https://openalex.org/W6958093362","https://openalex.org/W2737884695","https://openalex.org/W2782886454","https://openalex.org/W2136034214","https://openalex.org/W1990067439","https://openalex.org/W2026719046","https://openalex.org/W4224310461","https://openalex.org/W2085029809"],"abstract_inverted_index":{"Subjects":[0],"with":[1,35,39,88,144,322,348],"compared":[2],"to":[3,72,211,242,258,279,295],"those":[4],"without":[5,53],"chronic":[6],"kidney":[7],"disease":[8,15],"(CKD)":[9],"have":[10],"increased":[11,202,334,352],"risk":[12,31],"for":[13,190],"cardiovascular":[14],"(CVD).":[16],"We":[17],"tested":[18],"the":[19,167,184,204,222,269,306],"hypothesis":[20],"that":[21,90,313,340],"oral":[22],"alkali":[23,176,314,341],"as":[24,162],"Na+":[25,156],"citrate":[26,157],"improves":[27],"indices":[28,332],"of":[29,188,333,343],"CVD":[30,335,353],"in":[32,138,203,221,268,305,319,346],"primary":[33,320],"hypertensives":[34,38,321],"CKD.":[36],"Nonsmoking":[37],"CKD":[40,54,323,349],"(HTN-CKD,":[41],"calculated":[42,56],"GFR":[43,57],"=":[44,50,58,64,152,172,285,300],"35":[45],"\u00b1":[46,60,76,80,106,110,129,133,209,213,227,231,240,244,256,260,277,281,293,297],"3":[47,61],"mL/min,":[48,62],"n":[49,63],"15)":[51],"and":[52,78,116,192,252,327],"(HTN,":[55],"89":[59],"21)":[65],"had":[66,99],"systolic":[67],"blood":[68],"pressure":[69],"(BP)":[70],"reduced":[71],"similar":[73],"levels":[74],"(132":[75],"2":[77],"135":[79],"1":[81],"mm":[82],"Hg,":[83],"respectively)":[84],"over":[85],"six":[86,186,197],"months":[87,187],"regimens":[89],"included":[91],"angiotensin-converting":[92],"enzyme":[93],"inhibitors.":[94],"After":[95,196],"BP":[96,179,317],"reduction,":[97],"HTN-CKD":[98,142,169,194,206,224,271,308],"higher":[100,117],"serum":[101,145,199,325],"C-reactive":[102],"protein":[103],"(CRP)":[104],"(13.7":[105],"1.9":[107],"vs.":[108,131,229],"8.4":[109],"0.9":[111],"mg/L,":[112,246,283],"p":[113,135,216,234,247,262,284,299],"<":[114,136,148,217,235,248,263],".01)":[115],"urine":[118,253,290,328],"albumin":[119,329],"excretion":[120],"measured":[121],"by":[122],"(mg)":[123],"albumin-to-(g)":[124],"creatinine":[125],"(alb/cr)":[126],"ratio":[127],"(71.4":[128],"20.7":[130],"9.9":[132],"1.5,":[134],".002)":[137],"an":[139],"a.m.":[140],"specimen.":[141],"subjects":[143,170,207,225,272,347],"total":[146,200],"CO2":[147,201],"22":[149],"mM":[150],"(n":[151,171],"9)":[153],"were":[154],"prescribed":[155],"(1":[158],"meq":[159],"HCO3":[160],"equivalent/kg/day)":[161],"per":[163],"current":[164],"recommendations":[165],"but":[166,219,273],"remaining":[168],"6)":[173],"received":[174],"no":[175],"therapy.":[177],"Systolic":[178],"control":[180],"was":[181],"unchanged":[182],"throughout":[183],"additional":[185],"follow-up":[189],"alkali-treated":[191,205,270],"not-treated":[193],"subjects.":[195,309],"months,":[198],"(20.2":[208],"0.4":[210,214,232],"24.4":[212],"mM,":[215,233],".001)":[218],"decreased":[220,267],"untreated":[223,307],"(24.0":[226],"0.5":[228],"23.3":[230],".02).":[236],"Serum":[237],"CRP":[238,275,326],"(13.0":[239],"1.3":[241],"10.2":[243],"0.8":[245],".02,":[249],"paired":[250,265,287,302],"t)":[251,266,288,303],"alb/cr":[254,291],"(91.9":[255],"29.8":[257],"67.4":[259],"23.7,":[261],".007,":[264],"neither":[274],"(14.7":[276],"4.6":[278],"15.7":[280],"4.1":[282],".14,":[286],"nor":[289],"(40.8":[292],"23.4":[294],"44.2":[296],"20.4,":[298],".35,":[301],"changed":[304],"These":[310],"data":[311,338],"show":[312],"therapy":[315],"following":[316],"reduction":[318],"reduces":[324,350],"excretion,":[330],"two":[331],"risk.":[336,354],"The":[337],"suggest":[339],"amelioration":[342],"metabolic":[344],"acidosis":[345],"their":[351]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}