{"id":"https://openalex.org/W2381972288","doi":null,"title":"Extracellular Heat Shock Protein 70 and Its Biological Functions","display_name":"Extracellular Heat Shock Protein 70 and Its Biological Functions","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2381972288","mag":"2381972288"},"language":"en","primary_location":{"id":"mag:2381972288","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWWX200701005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764550733","display_name":"Yixue fenzi shengwuxue zazhi","issn_l":"1672-8009","issn":["1672-8009"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue fenzi shengwuxue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113905927","display_name":"Lingjia Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingjia Qian","raw_affiliation_strings":["Laboratory of stress Medicine,the Institute of Hygienic and Environmental Medicines,the Academy of Military Medical Sciences,Tianjin,300050,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of stress Medicine,the Institute of Hygienic and Environmental Medicines,the Academy of Military Medical Sciences,Tianjin,300050,China","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113905927"],"corresponding_institution_ids":["https://openalex.org/I2802541053"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24217938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.6470000147819519},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.6190000176429749},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5849999785423279},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7250000238418579},{"id":"https://openalex.org/keywords/disease-biomarkers","display_name":"disease biomarkers","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.792731523513794},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7724568843841553},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.6835871934890747},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.6334268450737},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.627377986907959},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5770406126976013},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5403743982315063},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43471601605415344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4247113764286041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3833698332309723},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3310040235519409},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27559709548950195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09635540843009949},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2381972288","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWWX200701005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764550733","display_name":"Yixue fenzi shengwuxue zazhi","issn_l":"1672-8009","issn":["1672-8009"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue fenzi shengwuxue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W160183570","https://openalex.org/W2338506454","https://openalex.org/W2810483490","https://openalex.org/W59259273","https://openalex.org/W2386113091","https://openalex.org/W1976692335","https://openalex.org/W4244611720","https://openalex.org/W2370884404","https://openalex.org/W2498529766","https://openalex.org/W38117370"],"abstract_inverted_index":{"Heat":[0],"shock":[1],"proteins(HSP)were":[2],"first":[3],"characterized":[4],"as":[5,74],"intracellular":[6],"proteins,which":[7],"function":[8,31],"to":[9,39,53],"limit":[10],"protein":[11,13],"aggregation,facilitate":[12],"refolding,and":[14],"chaperone":[15],"proteins.Recently,it":[16],"has":[17,48],"been":[18,49],"demonstrated":[19],"that":[20,51],"HSP70":[21],"are":[22,37],"also":[23],"found":[24,38],"extracellularly(eHSP70).Little":[25],"is":[26],"known":[27],"about":[28],"the":[29,43,60,80],"potential":[30],"of":[32,45,62,82],"extracellular":[33],"HSP70(eHSP70).Circulating":[34],"eHSP70":[35,63,72],"levels":[36],"increase":[40],"substantially":[41],"in":[42],"process":[44,81],"many":[46],"diseases.It":[47],"proposed":[50],"exposure":[52],"acute":[54],"physical":[55],"or":[56,67],"mental":[57],"stressors":[58],"stimulates":[59],"release":[61],"via":[64],"lipid":[65],"raft":[66],"exosome-mediated":[68],"mechanism":[69],"and":[70,78],"elevated":[71],"serves":[73],"an":[75],"active":[76],"cytokine":[77],"influence":[79],"disease.":[83]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
