{"id":"https://openalex.org/W2381960384","doi":null,"title":"Testis Specific Protein Y Encoded and Genome Wide Copy Number Variation and Changes in Individual Bulls","display_name":"Testis Specific Protein Y Encoded and Genome Wide Copy Number Variation and Changes in Individual Bulls","publication_year":2016,"publication_date":"2016-05-12","ids":{"openalex":"https://openalex.org/W2381960384","mag":"2381960384"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9685","pdf_url":"http://hdl.handle.net/10214/9685","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10214/9685","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091009505","display_name":"Olutobi Arinola Oluwole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Olutobi A. Oluwole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091009505"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/tspy","display_name":"TSPY","score":0.8130000233650208},{"id":"https://openalex.org/keywords/y-chromosome","display_name":"Y chromosome","score":0.7239999771118164},{"id":"https://openalex.org/keywords/bulls","display_name":"bulls","score":0.8169999718666077},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9079999923706055},{"id":"https://openalex.org/keywords/somatic-mosaicism","display_name":"somatic mosaicism","score":0.921999990940094},{"id":"https://openalex.org/keywords/in-vitro-aging","display_name":"in vitro aging","score":0.6650000214576721},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.781000018119812},{"id":"https://openalex.org/keywords/de-novo-copy-number-variants","display_name":"de novo copy number variants","score":0.7210000157356262},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.6280753016471863},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.6277822852134705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5690471529960632},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5663650035858154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5316728949546814},{"id":"https://openalex.org/C151020129","wikidata":"https://www.wikidata.org/wiki/Q7625067","display_name":"Structural variation","level":4,"score":0.43655329942703247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43510112166404724},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3796389102935791},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2474949061870575},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9685","pdf_url":"http://hdl.handle.net/10214/9685","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2381960384","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9685","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/9685","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/9685","pdf_url":"http://hdl.handle.net/10214/9685","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2381960384.pdf","grobid_xml":"https://content.openalex.org/works/W2381960384.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W845218119","https://openalex.org/W1510708869","https://openalex.org/W1538623601","https://openalex.org/W1607298914","https://openalex.org/W1826750984","https://openalex.org/W1827251660","https://openalex.org/W1876187171","https://openalex.org/W1964013868","https://openalex.org/W1969098092","https://openalex.org/W1970218988","https://openalex.org/W1973502710","https://openalex.org/W1983126085","https://openalex.org/W1984259444","https://openalex.org/W1987523847","https://openalex.org/W1989851193","https://openalex.org/W1992722091","https://openalex.org/W1993113631","https://openalex.org/W1993214867","https://openalex.org/W1994067034","https://openalex.org/W1994601218","https://openalex.org/W1997647094","https://openalex.org/W2001341519","https://openalex.org/W2001963621","https://openalex.org/W2002457457","https://openalex.org/W2004189780","https://openalex.org/W2005374438","https://openalex.org/W2006431749","https://openalex.org/W2007969716","https://openalex.org/W2009331966","https://openalex.org/W2012316424","https://openalex.org/W2016724961","https://openalex.org/W2020541351","https://openalex.org/W2021119954","https://openalex.org/W2023464119","https://openalex.org/W2026711486","https://openalex.org/W2027318023","https://openalex.org/W2028152017","https://openalex.org/W2035084538","https://openalex.org/W2036680899","https://openalex.org/W2037313882","https://openalex.org/W2038481472","https://openalex.org/W2042003147","https://openalex.org/W2042334736","https://openalex.org/W2043449536","https://openalex.org/W2044354585","https://openalex.org/W2044823121","https://openalex.org/W2045886931","https://openalex.org/W2047803717","https://openalex.org/W2047944830","https://openalex.org/W2049117580","https://openalex.org/W2049424035","https://openalex.org/W2050691945","https://openalex.org/W2051106817","https://openalex.org/W2051146905","https://openalex.org/W2055467457","https://openalex.org/W2055812542","https://openalex.org/W2057009728","https://openalex.org/W2059241865","https://openalex.org/W2060480089","https://openalex.org/W2063441475","https://openalex.org/W2068403109","https://openalex.org/W2069120646","https://openalex.org/W2071044751","https://openalex.org/W2074968742","https://openalex.org/W2078075583","https://openalex.org/W2081067541","https://openalex.org/W2081724110","https://openalex.org/W2082522400","https://openalex.org/W2085235236","https://openalex.org/W2088333129","https://openalex.org/W2089550096","https://openalex.org/W2093477592","https://openalex.org/W2095399096","https://openalex.org/W2098198038","https://openalex.org/W2101775966","https://openalex.org/W2102143829","https://openalex.org/W2102347283","https://openalex.org/W2108244474","https://openalex.org/W2110374888","https://openalex.org/W2115424432","https://openalex.org/W2118094114","https://openalex.org/W2120213589","https://openalex.org/W2123431154","https://openalex.org/W2123621585","https://openalex.org/W2127612936","https://openalex.org/W2132162088","https://openalex.org/W2134239088","https://openalex.org/W2134783591","https://openalex.org/W2136471190","https://openalex.org/W2138755755","https://openalex.org/W2142602296","https://openalex.org/W2142695851","https://openalex.org/W2144974645","https://openalex.org/W2146948473","https://openalex.org/W2147429782","https://openalex.org/W2150751047","https://openalex.org/W2156851441","https://openalex.org/W2160621707","https://openalex.org/W2160868309","https://openalex.org/W2162212014","https://openalex.org/W2163097146","https://openalex.org/W2166879144","https://openalex.org/W2167482501","https://openalex.org/W2168538295","https://openalex.org/W2170875020","https://openalex.org/W2183771447"],"related_works":["https://openalex.org/W2620411296","https://openalex.org/W2292479726","https://openalex.org/W2516707064","https://openalex.org/W2611200179","https://openalex.org/W1969098092","https://openalex.org/W2095426243","https://openalex.org/W2596446388","https://openalex.org/W2011908033","https://openalex.org/W845218119","https://openalex.org/W7098406882"],"abstract_inverted_index":{"Copy":[0,58],"number":[1,23,43,48,59,111,128,144,172,197,204,249,258,274,328,355,373,396],"variation":[2,24,44,60,173,275],"has":[3,36,70,387],"been":[4,37,71],"reported":[5,72],"in":[6,13,73,86,95,115,119,122,146,151,154,158,169,194,225,231,246,251,255,282,286,291,294,314,317,323,330,361,374,380,393,416],"health":[7],"and":[8,19,52,77,117,137,153,157,186,217,284,293,316,342,356,379,401,406],"disease":[9],"conditions.":[10],"Several":[11],"genes":[12,278],"the":[14,74,87,91,99,134,147,214,220,232,265,290,334,339,367,383,398],"genome":[15,141,149],"of":[16,56,101,133,201,276,382],"both":[17],"humans":[18],"animals":[20],"exhibit":[21,40],"copy":[22,42,47,96,110,127,143,171,196,203,248,257,273,327,354,372,395],"(CNV).":[25],"Testis":[26],"specific":[27],"protein":[28],"Y":[29,33,66,266,399],"encoded":[30],"(TSPY),":[31],"a":[32,184,192,350,413],"chromosomal":[34,67],"gene":[35,256],"shown":[38,388],"to":[39,65,105,139,264,370],"extensive":[41],"with":[45,113,174,198,259,280,311,325,344],"its":[46],"varying":[49,329],"among":[50,130],"individuals":[51],"between":[53,207],"different":[54,131,159,167,234,331],"breeds":[55],"bulls.":[57,163,336,417],"is":[61,82,261,366,412],"not":[62,190,262],"limited":[63,263],"only":[64],"genes,":[68],"but":[69],"X":[75],"chromosome":[76,400],"autosomes":[78],"as":[79,89],"well.":[80],"There":[81],"very":[83],"little":[84],"information":[85],"literature":[88],"regards":[90],"age":[92,114,222,260,281,312,390],"related":[93,391],"changes":[94,392],"number.":[97],"Therefore,":[98],"purpose":[100],"this":[102,365],"thesis":[103],"was":[104,242],"determine":[106],"(a)":[107],"whether":[108],"TSPY":[109,126,170,195,202,247,326,353,394],"varied":[112,206],"bulls":[116,177,218,283,376],"during":[118,150,250,285,313],"vitro":[120,155,226,252,287,295,318],"aging":[121,227,296],"cultured":[123],"fibroblasts":[124],"(b)":[125],"varies":[129],"tissues":[132,160,332,381],"same":[135,215,221,335,384],"bull,":[136],"(c)":[138],"analyzed":[140],"wide":[142,269],"variations":[145],"bull":[148],"vivo":[152,292,315],"aging,":[156],"within":[161,219],"individual":[162,375],"We":[164],"observed":[165,299],"three":[166],"trends":[168],"age.":[175,199],"Some":[176],"(26%)":[178],"showed":[179,271],"an":[180],"increase,":[181],"some":[182,187],"(7%)":[183],"decrease":[185],"(67%)":[188],"did":[189],"have":[191,349],"change":[193,205,245],"Pattern":[200],"pattern":[208],"half":[209],"siblings":[210],"(bulls":[211],"born":[212],"from":[213,333],"sire)":[216],"group.":[223],"Our":[224],"model":[228],"revealed":[229],"that":[230,272,409],"3":[233],"bovine":[235],"fibroblast":[236],"cell":[237],"lines":[238],"we":[239,298],"examined,":[240],"there":[241,305],"no":[243],"significant":[244],"aging.":[253,288,319],"Variation":[254],"chromosome.":[267],"Genome":[268],"analysis":[270],"autosomal":[277,404],"occurs":[279,322],"In":[289],"studies,":[297],"more":[300,307],"deletions":[301],"than":[302],"gains.":[303],"And":[304],"were":[306,359],"de":[308],"novo":[309],"CNVs":[310,358,402],"Somatic":[320],"mosaicism":[321,411],"bulls,":[324],"Tissues":[337],"like":[338],"brain,":[340],"lung":[341],"muscle":[343],"less":[345,357],"actively":[346],"dividing":[347],"cells":[348],"lower":[351],"relative":[352],"detected":[360],"them.":[362],"To":[363],"date,":[364],"first":[368],"study":[369],"monitor":[371],"over":[377],"time":[378],"bull.":[385],"It":[386],"important":[389],"on":[397,403],"chromosomes,":[405],"also":[407],"demonstrated":[408],"somatic":[410],"common":[414],"feature":[415]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}