{"id":"https://openalex.org/W2381945286","doi":"https://doi.org/10.3760/cma.j.issn.1003-0603.2006.06.014","title":"[Diagnostic value of procalcitonin in ventilator associated pneumonia].","display_name":"[Diagnostic value of procalcitonin in ventilator associated pneumonia].","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2381945286","doi":"https://doi.org/10.3760/cma.j.issn.1003-0603.2006.06.014","mag":"2381945286","pmid":"https://pubmed.ncbi.nlm.nih.gov/16784569"},"language":"zh","primary_location":{"id":"pmid:16784569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16784569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037992989","display_name":"Cheng-dun Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng-dun Zhou","raw_affiliation_strings":["Futian People's Hospital, Guangdong Medical College, Shenzhen 518033, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Futian People's Hospital, Guangdong Medical College, Shenzhen 518033, Guangdong, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083452187","display_name":"Zeyuan Lu","orcid":"https://orcid.org/0000-0002-3002-9723","observed_orcids":["https://orcid.org/0000-0002-3002-9723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ze-yuan Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031046462","display_name":"Nan-zheng Ren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nan-zheng Ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049221768","display_name":"Guichang Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gui-chang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8562,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.80242915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"18","issue":"6","first_page":"370","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.6894999742507935,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.29910001158714294,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventilator-associated-pneumonia","display_name":"ventilator-associated pneumonia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":1.0},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8579999804496765},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6140000224113464},{"id":"https://openalex.org/keywords/infection-diagnosis","display_name":"infection diagnosis","score":0.5},{"id":"https://openalex.org/keywords/sepsis-biomarkers","display_name":"sepsis biomarkers","score":0.5109999775886536},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.4830000102519989},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.3440000116825104},{"id":"https://openalex.org/keywords/duration-of-mechanical-ventilation","display_name":"mechanical ventilation duration","score":0.4620000123977661},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.4950000047683716},{"id":"https://openalex.org/keywords/icu-length-of-stay","display_name":"ICU length of stay","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C10936531","wikidata":"https://www.wikidata.org/wiki/Q786600","display_name":"Procalcitonin","level":3,"score":0.9802454710006714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9377930164337158},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.7665377855300903},{"id":"https://openalex.org/C2777184939","wikidata":"https://www.wikidata.org/wiki/Q7920253","display_name":"Ventilator-associated pneumonia","level":3,"score":0.7051681876182556},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6994054317474365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.687794029712677},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6750612258911133},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5934723615646362},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5631201267242432},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.32337552309036255},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.12231388688087463}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012122","descriptor_name":"Ventilators, Mechanical","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16784569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16784569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","raw_type":"Journal Article"},{"id":"mag:2381945286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16784569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3032546769","doi":"https://doi.org/10.3760/cma.j.issn.1003-0603.2006.06.014","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN121430200606/586925.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306506051","display_name":"Chin Crit Care Med","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chin Crit Care Med","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030549044","https://openalex.org/W97789655","https://openalex.org/W2360900032","https://openalex.org/W2393078859","https://openalex.org/W3032154676","https://openalex.org/W2385832651","https://openalex.org/W2754771520","https://openalex.org/W2899885515","https://openalex.org/W1985871141","https://openalex.org/W2166220602"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,31,46,85,106,210,213,235,258,296,311,316],"diagnostic":[4,143],"value":[5,287],"of":[6,48,58,145,239,247,253,260,288,298,304,313],"procalcitonin":[7],"(PCT)":[8],"quantification":[9],"in":[10,35,61,115,132,295,315],"ventilator":[11],"associated":[12],"pneumonia":[13],"(VAP).":[14],"METHODS:":[15],"Sixty-one":[16],"patients":[17,32],"on":[18,29],"ventilators":[19],"were":[20,43,67,99,126,152,177,192],"divided":[21],"into":[22,69],"VAP":[23,34,133,138,151,222,226,240,249,261,314],"group":[24,27,134,139,223,227,241],"and":[25,53,79,93,108,123,147,156,167,172,182,187,196,224,278],"non-VAP":[26],"depending":[28],"whether":[30],"developed":[33],"7":[36,54],"days":[37,55],"or":[38,81,204],"not.":[39],"The":[40,64,120,142,251,286],"PCT":[41,65,214,236,255,290,306],"levels":[42,66],"determined":[44],"with":[45,136,266],"method":[47],"semi-solid":[49],"phase":[50],"immunoassay":[51],"before":[52,228],"after":[56,233],"instillation":[57],"mechanical":[59,104,229],"ventilation":[60,230],"these":[62],"patients.":[63],"graded":[68],"four":[70],"categories,":[71],"i.e.":[72],"<0.5":[73],"microg/L,":[74,76],"0.5-2.0":[75],"2.0-10.0":[77],"microg/L":[78,206],">":[80],"=10.0":[82],"microg/L.":[83],"At":[84],"same":[86],"time,":[87],"C":[88],"reactive":[89],"protein":[90],"(CRP)":[91],"content":[92,122],"white":[94],"blood":[95],"cell":[96],"(WBC)":[97],"count":[98,110,125,149],"also":[100],"determined.":[101],"RESULTS:":[102],"Before":[103],"ventilation,":[105],"CRP":[107,121,146],"WBC":[109,124,148],"showed":[111],"no":[112],"obvious":[113],"difference":[114,220],"both":[116],"groups":[117],"(all":[118,140],"P>0.05).":[119],"found":[127],"to":[128],"be":[129],"obviously":[130],"elevated":[131],"compared":[135],"non":[137,225,248],"P=0.000).":[141],"sensitivity":[144,252,293],"for":[150,257,310],"73.5%":[153],"(25/34":[154],"cases)":[155,159,166,181,195],"82.3%":[157],"(28/34":[158],"respectively,":[160,171,186],"their":[161,173,188],"specificity":[162,267],"was":[163,207,242,262],"48.1%":[164],"(13/27":[165],"55.5%":[168],"(15/27":[169],"cases),":[170,185,199,265,271,277],"positive":[174,215,237,272],"prediction":[175,190,273,280],"rates":[176,191],"64.":[178],"1%":[179],"(25/39":[180],"70.0%":[183],"(28/40":[184],"negative":[189,279],"59.1%":[193],"(13/22":[194],"71.4%":[197],"(15/21":[198],"respectively.":[200],"If":[201],"serum":[202,254,289,305],"PCT>":[203],"=0.5":[205],"regarded":[208],"as":[209],"cutoff":[211],"value,":[212],"percentage":[216,238],"did":[217],"not":[218],"show":[219],"between":[221],"(P>0.05).":[231],"However,":[232],"VAP,":[234,299],"much":[243],"higher":[244],"than":[245],"that":[246,301],"group.":[250],"determination":[256],"diagnosis":[259,297,312],"85.3%":[263],"(29/34":[264],"rate":[268,274,281,294],"74.1%":[269],"(20/27":[270],"80.5%":[275],"(29/36":[276],"80.0%":[282],"(20/25":[283],"cases).":[284],"CONCLUSION:":[285],"has":[291],"high":[292],"so":[300],"timely":[302],"surveillance":[303],"change":[307],"is":[308],"helpful":[309],"early":[317],"stage.":[318]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}