{"id":"https://openalex.org/W238157698","doi":null,"title":"The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study.","display_name":"The role of melatonin receptor 1B gene (MTNR1B) in adolescent idiopathic scoliosis--a genetic association study.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W238157698","mag":"238157698","pmid":"https://pubmed.ncbi.nlm.nih.gov/17108395"},"language":"en","primary_location":{"id":"pmid:17108395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17108395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101484624","display_name":"Xiaoqiang Qiu","orcid":"https://orcid.org/0000-0002-2442-4073","observed_orcids":["https://orcid.org/0000-0002-2442-4073"]},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X S Qiu","raw_affiliation_strings":["The Affiliated Drum Town Hospital of Nanjing University Medical School, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Drum Town Hospital of Nanjing University Medical School, Nanjing, China","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735664","display_name":"Nelson L.S. Tang","orcid":"https://orcid.org/0000-0002-3607-5819","observed_orcids":["https://orcid.org/0000-0002-3607-5819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N L Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109409028","display_name":"H.Y. Yeung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Y Yeung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038744509","display_name":"Yan-Yu Qiu","orcid":"https://orcid.org/0000-0003-2185-5721","observed_orcids":["https://orcid.org/0000-0003-2185-5721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Qiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058273834","display_name":"Linyuan Qin","orcid":"https://orcid.org/0000-0002-2691-3903","observed_orcids":["https://orcid.org/0000-0002-2691-3903","https://orcid.org/0009-0002-7575-829X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Qin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013801699","display_name":"K M Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088079144","display_name":"Jack C. Y. Cheng","orcid":"https://orcid.org/0000-0001-8153-364X","observed_orcids":["https://orcid.org/0000-0001-8153-364X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Y Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5397,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87556579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"123","issue":null,"first_page":"3","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11030","display_name":"Scoliosis diagnosis and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11030","display_name":"Scoliosis diagnosis and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12830","display_name":"Pectus Deformity Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-idiopathic-scoliosis","display_name":"adolescent idiopathic scoliosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mtnr1b","display_name":"MTNR1B","score":0.9380000233650208},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.859000027179718},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7210000157356262},{"id":"https://openalex.org/keywords/haplotype-tagging","display_name":"haplotype tagging","score":0.722000002861023},{"id":"https://openalex.org/keywords/curve-severity","display_name":"curve severity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cobb-angle","display_name":"Cobb angle","score":0.8489999771118164},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C177580304","wikidata":"https://www.wikidata.org/wiki/Q1147298","display_name":"International HapMap Project","level":5,"score":0.8321667909622192},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6526695489883423},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6119140982627869},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.5601593852043152},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.48935335874557495},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.48247554898262024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4663699269294739},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.45924025774002075},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.445727676153183},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37458986043930054},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36540207266807556},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34145402908325195},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2796052396297455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21395063400268555}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012600","descriptor_name":"Scoliosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012600","descriptor_name":"Scoliosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044094","descriptor_name":"Receptors, Melatonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17108395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17108395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":"Journal Article"},{"id":"mag:238157698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17108395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043651315","https://openalex.org/W2072789550","https://openalex.org/W2057010715","https://openalex.org/W2073209193","https://openalex.org/W2390170406","https://openalex.org/W3028752707","https://openalex.org/W2340832640","https://openalex.org/W2791927813","https://openalex.org/W3029171493","https://openalex.org/W1071113295"],"abstract_inverted_index":{"UNLABELLED:":[0],"Many":[1],"studies":[2,15],"have":[3,16,38],"demonstrated":[4],"the":[5,10,26,40,65,70,77,88,108,139,143,153,160,198,203,213,217,221,229,238,241],"role":[6,41,239],"of":[7,12,23,42,57,69,79,90,107,129,142,159,200,212,220,240],"melatonin":[8,27,43,230,242],"in":[9,25,31,46,84,125,152,173,176,228,243],"etiology":[11],"AIS.":[13,49],"Previous":[14],"shown":[17],"that":[18],"there":[19],"is":[20],"no":[21,149,171,194],"evidence":[22],"mutations":[24],"receptor":[28,44],"1A":[29],"gene":[30,223],"AIS":[32,91,96,126,164,177,201,208,244],"patients.":[33,127],"In":[34,167],"this":[35],"study,":[36],"we":[37],"examined":[39],"1B":[45],"predisposition":[47],"for":[48,62],"Using":[50],"haplotype":[51],"block":[52],"tagging":[53,58,78],"technique,":[54],"a":[55,168],"set":[56],"SNPs":[59],"were":[60,102,132,135],"defined":[61],"MTNR1B":[63,85,144,222],"from":[64],"Han":[66],"Chinese":[67],"data":[68],"International":[71],"HapMap":[72],"project.":[73],"The":[74,104,117,190],"association":[75,195],"between":[76,111,163],"single":[80],"nucleotide":[81],"polymorphisms":[82],"(tSNPs)":[83],"region":[86,141,219],"and":[87,98,113,165,224],"occurrence":[89,199],"was":[92,110,120,148,179],"studied.":[93],"METHOD:":[94],"473":[95],"girls":[97],"311":[99],"normal":[100],"controls":[101],"recruited.":[103],"age":[105],"range":[106],"patients":[109,178,182],"10":[112],"18":[114],"years":[115],"old.":[116],"maximum":[118,204],"Cobb":[119,205],"recorded":[121],"at":[122],"latest":[123],"follow-up":[124],"Three":[128],"five":[130],"tSNPs":[131,162,192,215],"studied;":[133],"they":[134],"all":[136],"located":[137],"within":[138,207,216],"coding":[140],"gene.":[145],"RESULTS:":[146],"There":[147],"significant":[150],"difference":[151,172],"genotype":[154],"or":[155,202],"allelic":[156],"frequencies":[157],"(AF)":[158],"3":[161,191],"controls.":[166],"case-only":[169],"analysis,":[170],"curve":[174],"severity":[175],"found":[180],"among":[181],"with":[183,196],"different":[184],"genotypes":[185],"(by":[186],"one-way":[187],"ANOVA).":[188],"DISCUSSION:":[189],"showed":[193],"either":[197],"angle":[206],"girls.":[209,245],"Further":[210],"analysis":[211],"remaining":[214],"regulatory":[218],"other":[225],"related":[226],"genes":[227],"signaling":[231],"pathway":[232],"may":[233],"provide":[234],"further":[235],"information":[236],"on":[237]},"counts_by_year":[{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}