{"id":"https://openalex.org/W238104175","doi":null,"title":"Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium.","display_name":"Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium.","publication_year":1976,"publication_date":"1976-07-01","ids":{"openalex":"https://openalex.org/W238104175","mag":"238104175","pmid":"https://pubmed.ncbi.nlm.nih.gov/937512","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2032353"},"language":"en","primary_location":{"id":"pmid:937512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/937512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032353/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002161137","display_name":"Filiberto Giacomelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Giacomelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113529991","display_name":"Piero Anversa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Anversa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053286483","display_name":"Joseph Wiener","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wiener","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1948,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.89909021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"84","issue":"1","first_page":"111","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myocardium","display_name":"myocardium","score":0.8069999814033508},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.7670000195503235},{"id":"https://openalex.org/keywords/interendothelial-clefts","display_name":"interendothelial clefts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.6759999990463257},{"id":"https://openalex.org/keywords/epicardial-arteries","display_name":"epicardial arteries","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intramyocardial-arteries","display_name":"intramyocardial arteries","score":0.8500000238418579},{"id":"https://openalex.org/keywords/arterioles","display_name":"arterioles","score":0.8830000162124634},{"id":"https://openalex.org/keywords/myocardial-necrosis","display_name":"myocardial necrosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/myocardial-ischemic-injury","display_name":"myocardial ischemic injury","score":0.7620000243186951},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.9459999799728394},{"id":"https://openalex.org/keywords/coronary-circulation","display_name":"coronary circulation","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.7933413982391357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5965931415557861},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5861566662788391},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5562555193901062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.516727864742279},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4804089367389679},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.47293734550476074},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.4409337639808655},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4142100512981415},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40313148498535156},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.20281118154525757}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006735","descriptor_name":"Horseradish Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:937512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/937512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2032353","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032353/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:238104175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/937512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2032353","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2032353/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W36631690","https://openalex.org/W156104386","https://openalex.org/W180139333","https://openalex.org/W241116528","https://openalex.org/W252954355","https://openalex.org/W1427695666","https://openalex.org/W1472392470","https://openalex.org/W1529141639","https://openalex.org/W1591137397","https://openalex.org/W1595062875","https://openalex.org/W1687842363","https://openalex.org/W1695036386","https://openalex.org/W1754455313","https://openalex.org/W1966299443","https://openalex.org/W1975576699","https://openalex.org/W1981148223","https://openalex.org/W1982071727","https://openalex.org/W1985711398","https://openalex.org/W1990295308","https://openalex.org/W1999793750","https://openalex.org/W2000344683","https://openalex.org/W2006387884","https://openalex.org/W2014021386","https://openalex.org/W2022346538","https://openalex.org/W2025745642","https://openalex.org/W2026072007","https://openalex.org/W2030910978","https://openalex.org/W2038204666","https://openalex.org/W2044998924","https://openalex.org/W2046174983","https://openalex.org/W2046902532","https://openalex.org/W2050593291","https://openalex.org/W2057666723","https://openalex.org/W2059116827","https://openalex.org/W2059367249","https://openalex.org/W2060655901","https://openalex.org/W2065914370","https://openalex.org/W2081679747","https://openalex.org/W2085801491","https://openalex.org/W2093572243","https://openalex.org/W2108683773","https://openalex.org/W2114631182","https://openalex.org/W2129179416","https://openalex.org/W2140233303","https://openalex.org/W2172531133","https://openalex.org/W2175715156","https://openalex.org/W2264075669","https://openalex.org/W2307467836","https://openalex.org/W2312872944","https://openalex.org/W2342067247","https://openalex.org/W2343373252","https://openalex.org/W2397519183","https://openalex.org/W2405342422","https://openalex.org/W2411644560","https://openalex.org/W2413685787","https://openalex.org/W2418803577","https://openalex.org/W2419291008","https://openalex.org/W2419295967","https://openalex.org/W2435715611","https://openalex.org/W2462351094","https://openalex.org/W2465852388"],"related_works":["https://openalex.org/W2132341884","https://openalex.org/W1964071830","https://openalex.org/W1595062875","https://openalex.org/W1968456775","https://openalex.org/W148581379","https://openalex.org/W1982071727","https://openalex.org/W2264075669","https://openalex.org/W2034581527","https://openalex.org/W1975576699","https://openalex.org/W126844672"],"abstract_inverted_index":{"Acute":[0],"hypertension":[1],"has":[2],"been":[3,49],"produced":[4,188],"in":[5,103,130,134,199],"rats":[6],"by":[7,149,189],"the":[8,58,81,91,104,157,170,186,202,208],"intravenous":[9],"infusion":[10,111],"of":[11,40,60,83,88,94,99,106,115,118,139,160,176,205,214],"angiotensin":[12,110,206],"amide":[13],"for":[14,51],"4":[15],"hours.":[16],"Both":[17],"control":[18,64],"and":[19,38,46,72,86,112,124,173,179,193,211],"hypertensive":[20],"animals":[21,65],"were":[22],"injected":[23],"intravenously":[24],"prior":[25],"to":[26,56,166,185,201],"sacrifice":[27],"with":[28],"either":[29],"horseradish":[30],"peroxidase":[31],"(HRP)":[32],"or":[33,145],"colloidal":[34],"carbon.":[35],"Epicardial":[36],"arteries":[37,45,62,85,108,162,178],"blocks":[39],"ventricular":[41],"myocardium":[42],"containing":[43],"intramyocardial":[44,131],"arterioles":[47,87,180],"have":[48],"processed":[50],"electron":[52],"microscopy.":[53],"HRP":[54],"appears":[55],"penetrate":[57],"endoethelium":[59],"epicardial":[61,107,135,161],"from":[63],"within":[66],"vesicles":[67],"that":[68,156],"bypass":[69],"endothelial":[70],"junctions":[71],"empty":[73],"into":[74],"interendoethelial":[75],"clefts.":[76],"Peroxidase":[77],"does":[78],"not":[79,133],"traverse":[80],"endothelium":[82,105],"intramural":[84,119,177],"controls":[89],"over":[90],"10-minute":[92],"period":[93],"observation.":[95],"There":[96],"is":[97,154],"acceleration":[98],"lateral":[100],"vesicular":[101],"transport":[102],"after":[109],"direct":[113],"permeation":[114],"interendothelial":[116],"clefts":[117],"arterial":[120,136],"vessels.":[121,137],"Medial":[122],"fragmentation":[123],"more":[125,182],"extensive":[126],"necrosis":[127],"are":[128,151,181,196],"observed":[129],"but":[132],"Foci":[138],"myocardial":[140,194],"damage":[141],"resembling":[142],"irreversible":[143],"ischemic":[144],"anoxic":[146],"injury":[147],"followed":[148],"reflow":[150],"described.":[152],"It":[153],"suggested":[155],"increased":[158],"permeability":[159,172],"may":[163],"be":[164],"due":[165],"elevated":[167],"pressure,":[168],"while":[169],"altered":[171],"vascular":[174,192],"lesions":[175,195],"readily":[183],"attributable":[184],"vasoconstriction":[187],"angiotension.":[190],"The":[191],"also":[197],"discussed":[198],"relation":[200],"regional":[203],"actions":[204],"on":[207,218],"coronary":[209],"circulation":[210],"known":[212],"effects":[213],"this":[215],"vasoactive":[216],"peptide":[217],"myocardium.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}