{"id":"https://openalex.org/W23807015","doi":"https://doi.org/10.1007/978-1-4612-4266-6_14","title":"Tumor Suppressor Genes and Oncogenes in Human Prostate Cancer","display_name":"Tumor Suppressor Genes and Oncogenes in Human Prostate Cancer","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W23807015","doi":"https://doi.org/10.1007/978-1-4612-4266-6_14","mag":"23807015"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4612-4266-6_14","doi":"https://doi.org/10.1007/978-1-4612-4266-6_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-4266-6_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306462921","display_name":"Birkh\u00e4user Boston eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormones and Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W622546212","display_name":"Hormones and Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066248850","display_name":"Jill A. Macoska","orcid":"https://orcid.org/0000-0001-8471-2221","observed_orcids":["https://orcid.org/0000-0001-8471-2221"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jill A. Macoska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066248850"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02774566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"395","last_page":"414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.890999972820282},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/retinoblastoma-gene","display_name":"retinoblastoma gene","score":0.9459999799728394},{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gene-inactivation","display_name":"gene inactivation","score":0.671999990940094},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.7110000252723694},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7725698947906494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7087937593460083},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6568006277084351},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.6225978136062622},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6107217073440552},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5982033014297485},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5432314872741699},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5410571694374084},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.470938116312027},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4620596170425415},{"id":"https://openalex.org/C26567756","wikidata":"https://www.wikidata.org/wiki/Q2146845","display_name":"Suppressor mutation","level":4,"score":0.43046414852142334},{"id":"https://openalex.org/C84934515","wikidata":"https://www.wikidata.org/wiki/Q18033987","display_name":"SOCS6","level":4,"score":0.41547614336013794},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1788366734981537}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4612-4266-6_14","doi":"https://doi.org/10.1007/978-1-4612-4266-6_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4612-4266-6_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306462921","display_name":"Birkh\u00e4user Boston eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormones and Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W45711525","https://openalex.org/W68299364","https://openalex.org/W138310779","https://openalex.org/W164631372","https://openalex.org/W272049967","https://openalex.org/W1419228847","https://openalex.org/W1483323966","https://openalex.org/W1488193995","https://openalex.org/W1492993820","https://openalex.org/W1495871951","https://openalex.org/W1502326330","https://openalex.org/W1519595222","https://openalex.org/W1522090696","https://openalex.org/W1541516070","https://openalex.org/W1552426876","https://openalex.org/W1552542302","https://openalex.org/W1575078202","https://openalex.org/W1587842942","https://openalex.org/W1595222477","https://openalex.org/W1606316894","https://openalex.org/W1660065282","https://openalex.org/W1812479640","https://openalex.org/W1818588435","https://openalex.org/W1969525391","https://openalex.org/W1971874426","https://openalex.org/W1972153062","https://openalex.org/W1973690102","https://openalex.org/W1975593329","https://openalex.org/W1976718740","https://openalex.org/W1977752124","https://openalex.org/W1978881929","https://openalex.org/W1979822034","https://openalex.org/W1980637945","https://openalex.org/W1987070143","https://openalex.org/W1991763093","https://openalex.org/W1991957719","https://openalex.org/W1994559762","https://openalex.org/W1996449685","https://openalex.org/W2002931312","https://openalex.org/W2007599495","https://openalex.org/W2008301561","https://openalex.org/W2010057554","https://openalex.org/W2011120797","https://openalex.org/W2012924225","https://openalex.org/W2017767253","https://openalex.org/W2029343025","https://openalex.org/W2030045204","https://openalex.org/W2032191237","https://openalex.org/W2035159808","https://openalex.org/W2035244457","https://openalex.org/W2036247923","https://openalex.org/W2037722366","https://openalex.org/W2040974016","https://openalex.org/W2042337149","https://openalex.org/W2044954464","https://openalex.org/W2053099268","https://openalex.org/W2053989508","https://openalex.org/W2057563358","https://openalex.org/W2060725528","https://openalex.org/W2072320617","https://openalex.org/W2073101093","https://openalex.org/W2077858999","https://openalex.org/W2079701632","https://openalex.org/W2084557738","https://openalex.org/W2097974266","https://openalex.org/W2099742439","https://openalex.org/W2102590970","https://openalex.org/W2110565554","https://openalex.org/W2113225024","https://openalex.org/W2116020751","https://openalex.org/W2117337312","https://openalex.org/W2119798255","https://openalex.org/W2120435603","https://openalex.org/W2123335542","https://openalex.org/W2126619432","https://openalex.org/W2131287825","https://openalex.org/W2137330819","https://openalex.org/W2137504406","https://openalex.org/W2139062667","https://openalex.org/W2140501888","https://openalex.org/W2144351490","https://openalex.org/W2147543618","https://openalex.org/W2159594827","https://openalex.org/W2162920929","https://openalex.org/W2165170481","https://openalex.org/W2168884694","https://openalex.org/W2201991510","https://openalex.org/W2396068614","https://openalex.org/W2413197413","https://openalex.org/W2413460136","https://openalex.org/W2415758662","https://openalex.org/W2416023135","https://openalex.org/W2420507634","https://openalex.org/W2426274300","https://openalex.org/W2428071088","https://openalex.org/W2764885353","https://openalex.org/W3022296611","https://openalex.org/W4235925468"],"related_works":["https://openalex.org/W4232395388","https://openalex.org/W3191913738","https://openalex.org/W3096312397","https://openalex.org/W2479968031","https://openalex.org/W4255448838","https://openalex.org/W2333618020","https://openalex.org/W1976956469","https://openalex.org/W1562501703","https://openalex.org/W2034754552","https://openalex.org/W4322709030"],"abstract_inverted_index":{"A":[0],"tumor":[1,41,68,82,115,167,176,221],"suppressor":[2,42,83,116,168,177,222],"gene":[3,10,43,63,84,102,105,109,117,169,204,215,223],"may":[4,18,253],"be":[5,74,98,254],"broadly":[6],"defined":[7],"as":[8,256],"a":[9,88,114,160,201,207,220],"whose":[11],"inactivation":[12],"is":[13,110,128,136,163,173,216,248],"permissive":[14],"to":[15,34,66,99,165],"tumorigenesis.":[16],"Inactivation":[17],"occur":[19],"through":[20],"deletion":[21,39,54,93],"or":[22,38,55,92,138,150,189],"mutation":[23,37,56,91,153,195],"of":[24,40,61,78,90,113,154,159,219],"the":[25,51,62,76,101,120,131,134,148,226,244,251,257],"DNA":[26,44],"base":[27],"sequence.":[28],"Two":[29],"hypotheses":[30],"have":[31],"been":[32],"proposed":[33],"explain":[35],"how":[36],"sequences":[45],"inactivates":[46],"normal":[47,161],"genie":[48],"functions.":[49],"In":[50,147,192],"Knudson":[52,121],"hypothesis,":[53,122,152,194],"must":[57],"affect":[58],"both":[59,95],"alleles":[60],"in":[64,130,140,196,200],"order":[65],"disable":[67,100,166],"suppression":[69],"(Knudson,":[70],"1971).":[71],"As":[72],"might":[73],"expected,":[75],"effect":[77],"\u201ctwo":[79],"hits\u201d":[80],"on":[81],"integrity,":[85],"for":[86,123,175],"example,":[87,124],"combination":[89],"affecting":[94],"alleles,":[96],"would":[97],"from":[103],"encoding":[104],"product.":[106],"The":[107,213],"retinoblastoma":[108],"an":[111,217],"example":[112,218],"that":[118,179,182,224],"fulfills":[119,225],"one":[125,155,197],"mutant":[126,210],"allele":[127,156,162,198],"inherited":[129],"germline,":[132],"and":[133,209,232,241,250],"other":[135,190],"mutated":[137],"deleted":[139],"affected":[141],"tissues":[142],"(reviewed":[143,229],"by":[144,230,239,243],"Weinberg,":[145],"1992).":[146,234],"second,":[149],"\u201cdominant-negative\u201d":[151,227],"with":[157],"retention":[158],"sufficient":[164],"function.":[170],"This":[171,246],"rationale":[172],"appropriate":[174],"genes":[178],"encode":[180],"proteins":[181],"normally":[183],"form":[184],"homomeric":[185],"complexes":[186],"(e.g.,":[187,206],"dimers":[188],"oligomers).":[191],"this":[193],"results":[199],"heteromeric,":[202],"dys-functional":[203],"product":[205],"wild-type":[208],"protein":[211],"complex).":[212],"p53":[214],"hypothesis":[228],"Vogelstein":[231],"Kinzler,":[233],"These":[235],"keywords":[236,252],"were":[237],"added":[238],"machine":[240],"not":[242],"authors.":[245],"process":[247],"experimental":[249],"updated":[255],"learning":[258],"algorithm":[259],"improves.":[260]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}