{"id":"https://openalex.org/W23806796","doi":null,"title":"Cheminformatic and Mechanistic Study of Drug Subcellular Transport/Distribution.","display_name":"Cheminformatic and Mechanistic Study of Drug Subcellular Transport/Distribution.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W23806796","mag":"23806796"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89626","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89626","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/a82cad81-5138-4dd4-b047-37bbd304d435/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://deepblue.lib.umich.edu/bitstreams/a82cad81-5138-4dd4-b047-37bbd304d435/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nan Zheng","orcid":"https://orcid.org/0000-0002-8808-5154","observed_orcids":["https://orcid.org/0000-0002-8808-5154"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nan Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8808-5154","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.07779999822378159,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7260000109672546},{"id":"https://openalex.org/keywords/organelle-targeting","display_name":"organelle targeting","score":0.6880000233650208},{"id":"https://openalex.org/keywords/intracellular-accumulation","display_name":"intracellular accumulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"synthetic biology","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cellular-pharmacokinetics","display_name":"cellular pharmacokinetics","score":0.625},{"id":"https://openalex.org/keywords/drug-candidate-screening","display_name":"drug candidate screening","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5465523600578308},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5164444446563721},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3930225670337677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3827897012233734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3468042016029358},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21935218572616577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2078423798084259},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11941653490066528},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89626","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89626","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/a82cad81-5138-4dd4-b047-37bbd304d435/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:23806796","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/89626","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/89626","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/a82cad81-5138-4dd4-b047-37bbd304d435/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W23806796.pdf","grobid_xml":"https://content.openalex.org/works/W23806796.grobid-xml"},"referenced_works_count":289,"referenced_works":["https://openalex.org/W58176467","https://openalex.org/W205982582","https://openalex.org/W1484059593","https://openalex.org/W1487822126","https://openalex.org/W1515803461","https://openalex.org/W1523274332","https://openalex.org/W1538651517","https://openalex.org/W1571185475","https://openalex.org/W1571546288","https://openalex.org/W1580816202","https://openalex.org/W1585514236","https://openalex.org/W1588830049","https://openalex.org/W1595749894","https://openalex.org/W1695930458","https://openalex.org/W1822446348","https://openalex.org/W1877053426","https://openalex.org/W1888455958","https://openalex.org/W1901283126","https://openalex.org/W1919757304","https://openalex.org/W1944255103","https://openalex.org/W1947716969","https://openalex.org/W1963801361","https://openalex.org/W1964093308","https://openalex.org/W1964894520","https://openalex.org/W1968720831","https://openalex.org/W1969583408","https://openalex.org/W1970084895","https://openalex.org/W1970401090","https://openalex.org/W1971305333","https://openalex.org/W1972708116","https://openalex.org/W1973020582","https://openalex.org/W1973742211","https://openalex.org/W1974236818","https://openalex.org/W1974825648","https://openalex.org/W1975656014","https://openalex.org/W1976100892","https://openalex.org/W1977044468","https://openalex.org/W1978333877","https://openalex.org/W1978388868","https://openalex.org/W1979129343","https://openalex.org/W1979147708","https://openalex.org/W1979220266","https://openalex.org/W1979355851","https://openalex.org/W1979735910","https://openalex.org/W1980541144","https://openalex.org/W1981020538","https://openalex.org/W1981389898","https://openalex.org/W1983684735","https://openalex.org/W1984760567","https://openalex.org/W1984851754","https://openalex.org/W1985478695","https://openalex.org/W1986254790","https://openalex.org/W1987128119","https://openalex.org/W1987885263","https://openalex.org/W1987893453","https://openalex.org/W1989238270","https://openalex.org/W1989741821","https://openalex.org/W1989990191","https://openalex.org/W1990411057","https://openalex.org/W1991055159","https://openalex.org/W1992769097","https://openalex.org/W1993015516","https://openalex.org/W1993543551","https://openalex.org/W1993818918","https://openalex.org/W1993865998","https://openalex.org/W1994880547","https://openalex.org/W1996728254","https://openalex.org/W1997355056","https://openalex.org/W1998359769","https://openalex.org/W1999272804","https://openalex.org/W1999704534","https://openalex.org/W2000482482","https://openalex.org/W2001139215","https://openalex.org/W2002193947","https://openalex.org/W2002583617","https://openalex.org/W2002635986","https://openalex.org/W2003223378","https://openalex.org/W2003337014","https://openalex.org/W2004963632","https://openalex.org/W2006616385","https://openalex.org/W2007396482","https://openalex.org/W2007505141","https://openalex.org/W2007728890","https://openalex.org/W2007891562","https://openalex.org/W2009038858","https://openalex.org/W2010021881","https://openalex.org/W2010300252","https://openalex.org/W2012737246","https://openalex.org/W2013580319","https://openalex.org/W2015538125","https://openalex.org/W2016062690","https://openalex.org/W2018023039","https://openalex.org/W2018079000","https://openalex.org/W2018173377","https://openalex.org/W2018196278","https://openalex.org/W2018226695","https://openalex.org/W2018622482","https://openalex.org/W2019557881","https://openalex.org/W2019688392","https://openalex.org/W2020221058","https://openalex.org/W2020956292","https://openalex.org/W2021557629","https://openalex.org/W2022038655","https://openalex.org/W2022376905","https://openalex.org/W2026927904","https://openalex.org/W2027947397","https://openalex.org/W2028390740","https://openalex.org/W2028474406","https://openalex.org/W2028925696","https://openalex.org/W2029959277","https://openalex.org/W2030081715","https://openalex.org/W2030415476","https://openalex.org/W2031978408","https://openalex.org/W2032511569","https://openalex.org/W2033045117","https://openalex.org/W2033229805","https://openalex.org/W2033256212","https://openalex.org/W2033301024","https://openalex.org/W2033589385","https://openalex.org/W2034268083","https://openalex.org/W2034879954","https://openalex.org/W2035906823","https://openalex.org/W2035995705","https://openalex.org/W2036174328","https://openalex.org/W2036940831","https://openalex.org/W2036946743","https://openalex.org/W2038247151","https://openalex.org/W2038563978","https://openalex.org/W2039106845","https://openalex.org/W2041329246","https://openalex.org/W2042106494","https://openalex.org/W2042393861","https://openalex.org/W2042993926","https://openalex.org/W2045368640","https://openalex.org/W2045748010","https://openalex.org/W2046244841","https://openalex.org/W2046432380","https://openalex.org/W2046545813","https://openalex.org/W2047758994","https://openalex.org/W2048848797","https://openalex.org/W2049144802","https://openalex.org/W2051602817","https://openalex.org/W2052399139","https://openalex.org/W2053272866","https://openalex.org/W2053727115","https://openalex.org/W2053990285","https://openalex.org/W2054471415","https://openalex.org/W2056851369","https://openalex.org/W2057588560","https://openalex.org/W2057932372","https://openalex.org/W2058187882","https://openalex.org/W2058249868","https://openalex.org/W2058445327","https://openalex.org/W2058774662","https://openalex.org/W2059164393","https://openalex.org/W2061115935","https://openalex.org/W2063821921","https://openalex.org/W2063987302","https://openalex.org/W2064285157","https://openalex.org/W2065103311","https://openalex.org/W2065268472","https://openalex.org/W2065644790","https://openalex.org/W2065737912","https://openalex.org/W2066560540","https://openalex.org/W2066889228","https://openalex.org/W2069570359","https://openalex.org/W2070229001","https://openalex.org/W2070639936","https://openalex.org/W2070883788","https://openalex.org/W2071192915","https://openalex.org/W2072009964","https://openalex.org/W2072791430","https://openalex.org/W2073788301","https://openalex.org/W2074076128","https://openalex.org/W2074322766","https://openalex.org/W2076296181","https://openalex.org/W2076869647","https://openalex.org/W2076919958","https://openalex.org/W2076958319","https://openalex.org/W2077694384","https://openalex.org/W2078835466","https://openalex.org/W2079189479","https://openalex.org/W2079541326","https://openalex.org/W2080279469","https://openalex.org/W2080361931","https://openalex.org/W2080742684","https://openalex.org/W2081019782","https://openalex.org/W2081371282","https://openalex.org/W2081475314","https://openalex.org/W2081589302","https://openalex.org/W2084978560","https://openalex.org/W2086098893","https://openalex.org/W2088715137","https://openalex.org/W2088806233","https://openalex.org/W2089712488","https://openalex.org/W2090453432","https://openalex.org/W2091239867","https://openalex.org/W2093394396","https://openalex.org/W2093636101","https://openalex.org/W2093763598","https://openalex.org/W2094095836","https://openalex.org/W2095485042","https://openalex.org/W2095514613","https://openalex.org/W2096490067","https://openalex.org/W2096535122","https://openalex.org/W2096597046","https://openalex.org/W2096759740","https://openalex.org/W2097514325","https://openalex.org/W2097521067","https://openalex.org/W2098799558","https://openalex.org/W2099064181","https://openalex.org/W2099386789","https://openalex.org/W2099644823","https://openalex.org/W2099984416","https://openalex.org/W2101324236","https://openalex.org/W2101449590","https://openalex.org/W2101657078","https://openalex.org/W2101965284","https://openalex.org/W2102857711","https://openalex.org/W2103252941","https://openalex.org/W2105702785","https://openalex.org/W2107166355","https://openalex.org/W2107312415","https://openalex.org/W2109760026","https://openalex.org/W2111732338","https://openalex.org/W2115299925","https://openalex.org/W2115668137","https://openalex.org/W2119098586","https://openalex.org/W2123902908","https://openalex.org/W2125156658","https://openalex.org/W2125280858","https://openalex.org/W2128924784","https://openalex.org/W2130101808","https://openalex.org/W2130359925","https://openalex.org/W2130618352","https://openalex.org/W2131115067","https://openalex.org/W2131126105","https://openalex.org/W2131207346","https://openalex.org/W2135195608","https://openalex.org/W2135740730","https://openalex.org/W2135804407","https://openalex.org/W2135945868","https://openalex.org/W2137854825","https://openalex.org/W2138034636","https://openalex.org/W2139607149","https://openalex.org/W2139793307","https://openalex.org/W2141932654","https://openalex.org/W2142628334","https://openalex.org/W2144491599","https://openalex.org/W2145617380","https://openalex.org/W2146625467","https://openalex.org/W2146726392","https://openalex.org/W2146967405","https://openalex.org/W2149301630","https://openalex.org/W2149320353","https://openalex.org/W2150744118","https://openalex.org/W2151962691","https://openalex.org/W2152270251","https://openalex.org/W2154734205","https://openalex.org/W2155478211","https://openalex.org/W2155710404","https://openalex.org/W2155884605","https://openalex.org/W2156864427","https://openalex.org/W2157210567","https://openalex.org/W2158187981","https://openalex.org/W2160416906","https://openalex.org/W2162664876","https://openalex.org/W2162916961","https://openalex.org/W2164042904","https://openalex.org/W2164743326","https://openalex.org/W2166271857","https://openalex.org/W2167122375","https://openalex.org/W2169189990","https://openalex.org/W2169741467","https://openalex.org/W2171857291","https://openalex.org/W2213002714","https://openalex.org/W2242174805","https://openalex.org/W2252779726","https://openalex.org/W2267378377","https://openalex.org/W2315996234","https://openalex.org/W2337216472","https://openalex.org/W2340723176","https://openalex.org/W2398294812","https://openalex.org/W2412849200","https://openalex.org/W2413616721","https://openalex.org/W2886709486","https://openalex.org/W2951321431","https://openalex.org/W4250743572","https://openalex.org/W4253258573"],"related_works":["https://openalex.org/W2053610032","https://openalex.org/W1540925384","https://openalex.org/W26991484","https://openalex.org/W2165758944","https://openalex.org/W4402221837","https://openalex.org/W2145066118","https://openalex.org/W2894117724","https://openalex.org/W7097158525","https://openalex.org/W2017459842","https://openalex.org/W182063461"],"abstract_inverted_index":{"The":[0,82,102],"subcellular":[1,40,97,125,156,183,208],"transport":[2,41,98,139,160,179],"and":[3,15,23,34,48,69,73,78,99,141,153,158,178,184,201,228,240],"distribution":[4,100,157,177],"behavior":[5,55,180,227],"determines":[6],"both":[7],"the":[8,12,16,29,39,151,191,198,211,223,233,242],"pharmacological":[9],"effect":[10],"on":[11],"cellular":[13,53],"level":[14],"drug":[17,96,173],"exposure":[18],"at":[19,181],"a":[20,45,91,142,182,219],"tissue,":[21],"organ":[22],"whole":[24],"body":[25],"level.":[26,186],"Despite":[27],"of":[28,42,52,85,105,109,116,155,193,203,213,222,235,244],"rapid":[30],"evolution":[31],"in":[32,76,114,206],"experimental":[33,50,195,237],"computational":[35,59,121],"approaches":[36],"for":[37,64,95,123,172,197],"studying":[38],"small":[43,110,136],"molecules,":[44],"thorough":[46],"understanding":[47,221],"reliable":[49],"analysis":[51,75,154,202],"pharmacokinetic":[54,77,126],"remain":[56],"challenging.":[57],"Mechanism-based":[58],"models":[60,122],"are":[61],"promising":[62],"tools":[63],"testing":[65],"hypothesis,":[66],"exploring":[67],"mechanism":[68],"guiding":[70],"experiment":[71],"design":[72,152,238],"data":[74],"system":[79,131],"biology":[80,246],"studies.":[81,101,250],"primary":[83],"goal":[84],"this":[86],"work":[87],"is":[88],"to":[89,119,134,149,168],"propose":[90],"hypothesis-driven,":[92,214],"simulation-guided":[93,236],"strategy":[94],"current":[103],"knowledge":[104],"organelle":[106],"targeting":[107],"features":[108],"molecules":[111,205],"was":[112,132,147],"analyzed":[113],"terms":[115],"its":[117],"relevance":[118],"developing":[120],"analyzing":[124],"behavior.":[127],"A":[128],"non-invasive":[129],"insert":[130],"designed":[133],"characterize":[135],"molecules\u2019":[137],"intercellular":[138,159,230],"kinetics,":[140],"mechanism-based":[143],"passive":[144],"diffusion":[145],"model":[146],"adapted":[148],"facilitate":[150],"experiments.":[161],"This":[162],"study":[163],"pointed":[164],"out":[165],"many":[166],"opportunities":[167,188],"advance":[169],"effective":[170],"screening":[171],"candidates":[174],"with":[175],"desirable":[176],"systemic":[185],"These":[187],"include:":[189],"1)":[190],"development":[192],"quantitative":[194],"platform":[196],"real-time":[199],"tracking":[200],"non-fluorescent":[204],"multiple":[207],"compartments;":[209],"2)":[210],"elaboration":[212],"mechanistic":[215],"modeling":[216],"techniques":[217],"emphasizing":[218],"better":[220],"non-steady-state":[224],"intracellular":[225],"accumulation":[226],"limited":[229],"diffusivity;":[231],"3)":[232],"promotion":[234],"strategy;":[239],"4)":[241],"incorporation":[243],"synthetic":[245],"concepts":[247],"into":[248],"pharmacokinetics":[249]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}