{"id":"https://openalex.org/W2380109522","doi":null,"title":"Research progress of relationship between kainate receptors and neurodegenerative diseases","display_name":"Research progress of relationship between kainate receptors and neurodegenerative diseases","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2380109522","mag":"2380109522"},"language":"en","primary_location":{"id":"mag:2380109522","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYLN201404041.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764497753","display_name":"Chinese Journal of New Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of New Clinical Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Le Yuan","orcid":"https://orcid.org/0000-0002-0974-9566","observed_orcids":["https://orcid.org/0000-0002-0974-9566"]},"institutions":[{"id":"https://openalex.org/I165911609","display_name":"Changsha Medical University","ror":"https://ror.org/05dt7z971","country_code":"CN","type":"education","lineage":["https://openalex.org/I165911609"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Le Yuan","raw_affiliation_strings":["Changsha Medical University"],"raw_orcid":"https://orcid.org/0000-0002-0974-9566","affiliations":[{"raw_affiliation_string":"Changsha Medical University","institution_ids":["https://openalex.org/I165911609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165911609"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.22069314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kainate-receptors","display_name":"kainate receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9829999804496765},{"id":"https://openalex.org/keywords/excitatory-neurotransmitter","display_name":"excitatory neurotransmitter","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.878000020980835},{"id":"https://openalex.org/keywords/receptor-overexpression","display_name":"receptor overexpression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.9150940179824829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7679413557052612},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7452312707901001},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6138316988945007},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.46748536825180054},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4480286240577698},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.42419862747192383},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3525371551513672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14812609553337097},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.14108401536941528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13027074933052063},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09008333086967468},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2380109522","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYLN201404041.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764497753","display_name":"Chinese Journal of New Clinical Medicine","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of New Clinical Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1516847526","https://openalex.org/W3167955668","https://openalex.org/W7095366100","https://openalex.org/W2038017090","https://openalex.org/W7096445050","https://openalex.org/W4409829627","https://openalex.org/W2138295391","https://openalex.org/W3159716719","https://openalex.org/W3178071059","https://openalex.org/W2071955212"],"abstract_inverted_index":{"Studies":[0],"have":[1],"shown":[2],"that":[3],"the":[4,35],"kainate":[5],"receptors(":[6],"KARs)":[7],"plays":[8],"a":[9],"very":[10],"important":[11],"role":[12],"in":[13],"neurodegenerative":[14,46],"diseases.":[15,47],"The":[16],"excitatory":[17],"neurotransmitters":[18],"can":[19,41],"cause":[20],"up-regulation":[21],"of":[22,32,37,39],"KARs":[23,40],"expression":[24],"and":[25],"neuronal":[26],"cell":[27],"death":[28],"through":[29],"excessive":[30],"activation":[31],"KARs.":[33],"Studying":[34],"mechanism":[36],"action":[38],"provide":[42],"treatment":[43],"target":[44],"for":[45]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}