{"id":"https://openalex.org/W237903802","doi":null,"title":"Purification of the Sm nuclear autoantigen. Detection and clinical significance of IgM antibody.","display_name":"Purification of the Sm nuclear autoantigen. Detection and clinical significance of IgM antibody.","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W237903802","mag":"237903802","pmid":"https://pubmed.ncbi.nlm.nih.gov/4017287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577198"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108593966","display_name":"K. Michael Pollard","orcid":"https://orcid.org/0000-0002-7269-4035","observed_orcids":["https://orcid.org/0000-0002-7269-4035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K M Pollard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065446697","display_name":"Eng M. Tan","orcid":"https://orcid.org/0000-0002-8711-3248","observed_orcids":["https://orcid.org/0000-0002-8711-3248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E M Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9764,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.96481683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"60","issue":"3","first_page":"586","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sm-antigen","display_name":"Sm antigen","score":0.8399999737739563},{"id":"https://openalex.org/keywords/nuclear-autoantigens","display_name":"nuclear autoantigens","score":0.6830000281333923},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.6840000152587891},{"id":"https://openalex.org/keywords/anti-sm-antibodies","display_name":"anti-Sm antibodies","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.625},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mixed-connective-tissue-disease","display_name":"mixed connective tissue disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibody-isotyping","display_name":"antibody isotyping","score":0.4410000145435333},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2776151748","wikidata":"https://www.wikidata.org/wiki/Q4320806","display_name":"Extractable nuclear antigens","level":5,"score":0.7845087051391602},{"id":"https://openalex.org/C2776153627","wikidata":"https://www.wikidata.org/wiki/Q1622407","display_name":"Mixed connective tissue disease","level":3,"score":0.7477121949195862},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6953978538513184},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6563404202461243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5041884183883667},{"id":"https://openalex.org/C196955773","wikidata":"https://www.wikidata.org/wiki/Q256632","display_name":"Immunodiffusion","level":3,"score":0.5023846626281738},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.46739134192466736},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.46329793334007263},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.4632742404937744},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42404255270957947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3716059625148773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3653069734573364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3236727714538574}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008947","descriptor_name":"Mixed Connective Tissue Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017411","descriptor_name":"Ribonucleoproteins, Small Nuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055517","descriptor_name":"snRNP Core Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1577198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:4017287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4017287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:237903802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4017287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1055493","https://openalex.org/W7529361","https://openalex.org/W160997634","https://openalex.org/W1485518974","https://openalex.org/W1494605757","https://openalex.org/W1496775456","https://openalex.org/W1530522395","https://openalex.org/W1532341752","https://openalex.org/W1608232370","https://openalex.org/W1647491433","https://openalex.org/W1967921399","https://openalex.org/W2005946614","https://openalex.org/W2011457680","https://openalex.org/W2014281089","https://openalex.org/W2016288440","https://openalex.org/W2018967405","https://openalex.org/W2021783076","https://openalex.org/W2022961230","https://openalex.org/W2027063893","https://openalex.org/W2031642976","https://openalex.org/W2032029264","https://openalex.org/W2064139685","https://openalex.org/W2082626537","https://openalex.org/W2086665691","https://openalex.org/W2091039005","https://openalex.org/W2122398974","https://openalex.org/W2125742485"],"related_works":["https://openalex.org/W2038194898","https://openalex.org/W1591983988","https://openalex.org/W165919372","https://openalex.org/W2011457680","https://openalex.org/W1525306627","https://openalex.org/W2417256243","https://openalex.org/W2039441576","https://openalex.org/W2396875803","https://openalex.org/W206590323","https://openalex.org/W1496775456"],"abstract_inverted_index":{"Sm":[0,78],"antigen":[1,35,39,44,49,52],"from":[2,139,156,166,201],"rabbit":[3],"thymus":[4],"acetone":[5],"powder":[6],"was":[7,22,61],"purified":[8,59],"using":[9],"a":[10,140,145],"combination":[11],"of":[12,24,118,192,203],"ammonium":[13],"sulphate":[14],"precipitation,":[15],"DEAE-Sephacel":[16],"and":[17,56,91,126,132,152,163,189],"hydroxyapatite":[18],"chromatography.":[19],"This":[20],"preparation":[21],"devoid":[23],"previously":[25],"identified":[26],"nuclear":[27,34],"antigens":[28],"including":[29],"ribonucleoprotein":[30],"(U1-RNP),":[31],"proliferating":[32],"cell":[33],"(PCNA),":[36],"Sj\u00f6gren's":[37,42,47],"syndrome":[38,43],"A":[40],"(SS-A/Ro),":[41],"B":[45],"(SS-B/La),":[46],"lupus":[48,160],"(SL),":[50],"scleroderma":[51],"70":[53],"(Scl-70),":[54],"DNA":[55],"histones.":[57],"The":[58],"material":[60],"used":[62],"in":[63,85,190],"an":[64],"enzyme":[65],"linked":[66],"immunosorbent":[67],"assay":[68],"(ELISA)":[69],"to":[70,187],"detect":[71],"anti-Sm":[72,95,104,182],"antibody.":[73,96],"All":[74],"sera":[75,99,121],"with":[76,158,168],"precipitating":[77],"antibody":[79,125,148],"detected":[80],"by":[81,105],"immunodiffusion":[82,106],"gave":[83,111],"reactions":[84,112],"ELISA":[86],"greater":[87,113],"than":[88,114],"0.40":[89,115],"OD405":[90],"contained":[92,122,129],"predominantly":[93],"IgG":[94],"Of":[97,134],"112":[98],"which":[100,110],"did":[101],"not":[102],"have":[103],"there":[107,178],"were":[108,155,165],"five":[109,120],"OD405.":[116],"Four":[117],"these":[119,135,193],"only":[123],"IgM":[124,131,188],"the":[127,195],"fifth":[128],"both":[130],"IgG.":[133],"five,":[136],"one":[137],"came":[138],"'normal'":[141],"control":[142],"who":[143],"had":[144],"positive":[146],"anti-nuclear":[147],"(ANA),":[149],"facial":[150],"rash":[151],"diabetes,":[153],"two":[154,164],"patients":[157,167,180,194],"systemic":[159],"erythematosus":[161],"(SLE)":[162],"mixed":[169],"connective":[170],"tissue":[171],"disease":[172],"(MCTD).":[173],"These":[174],"findings":[175],"demonstrate":[176],"that":[177,202],"are":[179],"whose":[181],"response":[183],"may":[184,198],"be":[185,199],"restricted":[186],"some":[191],"clinical":[196],"presentation":[197],"different":[200],"classical":[204],"SLE.":[205]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}