{"id":"https://openalex.org/W2379008461","doi":null,"title":"Therapeutic peptides based on HBcAg_(18-27) epitope can induce CT L response in vitro and in vivo","display_name":"Therapeutic peptides based on HBcAg_(18-27) epitope can induce CT L response in vitro and in vivo","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2379008461","mag":"2379008461"},"language":"en","primary_location":{"id":"mag:2379008461","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ200303000.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102201849","display_name":"Tong Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tong Shi","raw_affiliation_strings":["dong, WU Yu  zhang, BIAN Jiang, JIA Zheng  cai, ZHOU Wei, ZOU Li  yun"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dong, WU Yu  zhang, BIAN Jiang, JIA Zheng  cai, ZHOU Wei, ZOU Li  yun","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5102201849"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.49239999055862427,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.4318999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hbcag","display_name":"HBcAg","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hbv-core-antigen","display_name":"HBV core antigen","score":0.824999988079071},{"id":"https://openalex.org/keywords/cytotoxic-cd8-t-cells","display_name":"CD8+ cytotoxic T lymphocytes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hla-a2-restriction","display_name":"HLA-A2 restriction","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lipid-adjuvants","display_name":"lipid adjuvants","score":0.5770000219345093},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/peptide-immunogenicity","display_name":"peptide immunogenicity","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2779729466","wikidata":"https://www.wikidata.org/wiki/Q24723361","display_name":"HBcAg","level":5,"score":0.8787295818328857},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8717008233070374},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.8630454540252686},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.6370275020599365},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5725265145301819},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5569138526916504},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5158330798149109},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.48701244592666626},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4710032045841217},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4637243449687958},{"id":"https://openalex.org/C2777351567","wikidata":"https://www.wikidata.org/wiki/Q908822","display_name":"Toxoid","level":4,"score":0.4313245117664337},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42416948080062866},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41635000705718994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40851709246635437},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.35929304361343384},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.20056471228599548},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11133798956871033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10355237126350403},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.0823482871055603},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.06765002012252808}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2379008461","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-MYXZ200303000.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764367629","display_name":"Immunological Journal","issn_l":"1000-8861","issn":["1000-8861"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361730452","host_organization_name":"Army Medical University","host_organization_lineage":["https://openalex.org/P4361730452"],"host_organization_lineage_names":["Army Medical University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Immunological Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W25852371","https://openalex.org/W2409187404","https://openalex.org/W2388226269","https://openalex.org/W2373293980","https://openalex.org/W2008507118","https://openalex.org/W1985839241","https://openalex.org/W2015504393","https://openalex.org/W2037387436","https://openalex.org/W2094614919","https://openalex.org/W2031913338"],"abstract_inverted_index":{"Objective":[0],"To":[1],"design":[2],"by":[3],"computerized":[4],"molecular":[5],"des":[6],"ign":[7],"methods":[8],"therapeutic":[9],"polypeptides":[10,43],"against":[11,199],"chronic":[12,200],"hepatitis":[13,202],"B":[14,50,203],"infection":[15],"to":[16,20,125,152,159],"ex":[17],"plore":[18],"how":[19],"trigger":[21],"HLA":[22,77],"\u2160restricted":[23],"HBV":[24,54],"specific":[25],"CD8":[26,112,141],"+":[27,79,113,142],"T":[28,65],"cell":[29,161],"response":[30],"and":[31,49,57,61,186],"h":[32],"ence":[33],"eradicate":[34],"viruses":[35],"within":[36],"hepatocytes.":[37],"Methods":[38],"A":[39],"new":[40],"panel":[41],"of":[42,45,53,97,101,129,183],"comprised":[44],"the":[46,62,98,126,130,153,172,180],"immunodominant":[47],"CTL":[48,114,133,143,155],"ep":[51],"itopes":[52],"core":[55],"antigen(HBcAg)":[56],"Pre":[58],"S2":[59],"protein,":[60],"tetanus":[63],"toxoid":[64],"helper":[66],"epitope":[67,134,156],"were":[68,73,148],"synthesized,and":[69],"their":[70],"immunological":[71],"properties":[72],"inve":[74],"stigated":[75],"in":[76,86,105,110,137,150,165,175],"A2":[78],"human":[80,106],"peri":[81],"pheral":[82],"blood":[83],"mononuclear":[84],"cells(PBMCs)and":[85],"Bal":[87],"b/c":[88],"mice.Results":[89],"The":[90,168],"results":[91],"demonstrated":[92],"that":[93,171],"p":[94,122],"olypeptides":[95],"consist":[96],"three":[99],"kinds":[100],"epitopes":[102],"could":[103],"evoke":[104],"PBMCs":[107],"an":[108],"d":[109],"mice":[111],"response.":[115],"Palm":[116,187],"p44,a":[117],"polypeptide":[118],"which":[119,157],"covalently":[120],"linked":[121],"almitic":[123],"acids":[124],"carboxyl":[127],"termini":[128],"potent":[131],"HBcAg":[132],"as":[135],"built":[136,174],"adjuvant":[138,176],"induced":[139],"vigorous":[140],"response,":[144],"no":[145],"additional":[146],"adjuvants":[147],"necessary":[149],"comparison":[151],"free":[154],"failed":[158],"induce":[160],"med":[162],"iated":[163],"immunity":[164],"mice.":[166],"Conclusions":[167],"findings":[169],"indicate":[170],"lipidic":[173],"can":[177],"efficiently":[178],"improve":[179],"immuno":[181],"genicity":[182],"peptide":[184,197],"antigens,":[185],"p44":[188],"might":[189],"be":[190],"a":[191],"promising":[192],"candidate":[193],"for":[194],"t":[195],"herapeutic":[196],"vaccines":[198],"viral":[201],"infection.":[204]},"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-06-24T00:00:00"}
