{"id":"https://openalex.org/W2378972796","doi":null,"title":"Anorexia nervosa. From single SNP studies, through biomarkers, to genome-wide association","display_name":"Anorexia nervosa. From single SNP studies, through biomarkers, to genome-wide association","publication_year":2016,"publication_date":"2016-01-19","ids":{"openalex":"https://openalex.org/W2378972796","mag":"2378972796"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/324887","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/324887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/324887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055961312","display_name":"Marek K. Brandys","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marek K. Brandys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055961312"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7590000033378601},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9670000076293945},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9399999976158142},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pomc-gene","display_name":"POMC gene","score":0.9409999847412109},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.7120000123977661},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9229999780654907},{"id":"https://openalex.org/keywords/abdominal-adiposity","display_name":"abdominal fat","score":0.9229999780654907},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8109999895095825},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/serum-bdnf-levels","display_name":"serum BDNF","score":0.7730000019073486},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.7639999985694885},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"meta-analysis","score":0.5950000286102295},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2778524067","wikidata":"https://www.wikidata.org/wiki/Q17142059","display_name":"rs4680","level":5,"score":0.8777543306350708},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.815004289150238},{"id":"https://openalex.org/C2778163459","wikidata":"https://www.wikidata.org/wiki/Q7375573","display_name":"rs6265","level":5,"score":0.7927894592285156},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6895880103111267},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6682517528533936},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5398411750793457},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.4877844452857971},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47203198075294495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4262336492538452},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4025256037712097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3762472867965698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36137357354164124},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33765941858291626},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23194992542266846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17060688138008118},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/324887","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/324887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/324887","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/324887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Center Rudolf Magnus, 116. Utrecht University","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2378972796","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/324887","pdf_url":null,"source":{"id":"https://openalex.org/S4306504912","display_name":"Brain Center Rudolf Magnus","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Brain Center Rudolf Magnus","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/324887","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/324887","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1974062404","https://openalex.org/W1980584142","https://openalex.org/W1992810061","https://openalex.org/W2074362293","https://openalex.org/W2076660369","https://openalex.org/W2088373020","https://openalex.org/W2092964716","https://openalex.org/W2100218863","https://openalex.org/W2103550195","https://openalex.org/W2104650169","https://openalex.org/W2108356100","https://openalex.org/W2117720353","https://openalex.org/W2134453207","https://openalex.org/W2156759015"],"related_works":["https://openalex.org/W2104650169","https://openalex.org/W4300698937","https://openalex.org/W7111443777","https://openalex.org/W4309563340","https://openalex.org/W2292186837","https://openalex.org/W3048663799","https://openalex.org/W1998147008","https://openalex.org/W2063838385","https://openalex.org/W4387496933","https://openalex.org/W2101413010"],"abstract_inverted_index":{"The":[0,417,441,459],"research":[1,423,432],"in":[2,29,34,73,106,113,172,186,189,278,303,319,326,346,385,405,424,433,468],"this":[3,392],"thesis":[4,393],"focused":[5,150],"on":[6,44,84,151,155,297],"searching":[7],"for:":[8],"-the":[9,23,38,54],"genetic":[10,48,62,460],"variants":[11,24,39,63,112,334,408,479],"which":[12,25,40,161,272,368],"increase":[13,474],"or":[14],"decrease":[15],"the":[16,30,35,45,58,61,74,114,156,173,192,198,205,234,243,256,279,288,298,304,315,354,399,421,431,447,451,471],"risk":[17,96],"of":[18,50,57,102,130,175,179,255,266,283,300,307,353,383,391,402,420,450,462],"developing":[19],"anorexia":[20],"nervosa":[21],"(AN)":[22],"play":[26,275],"a":[27,90,142,170,264,276,295,411],"role":[28,171,277],"body-weight":[31,123],"related":[32,64,127],"parameters":[33],"general":[36,75],"population":[37,76],"might":[41,273],"shed":[42],"light":[43],"hypothetical":[46],"common":[47],"background":[49],"AN":[51,105,322,349,386,425,463,484],"and":[52,60,88,118,124,137,158,165,203,223,241,249,253,268,281,293,331,387],"obesity":[53],"biochemical":[55],"markers":[56],"disease":[59],"to":[65,121,201,263,358,370,430,483],"them.":[66],"Single-nucleotide":[67],"polymorphisms":[68],"(SNPs)":[69],"associated":[70,228,338,360,409,480],"with":[71,81,104,132,211,229,309,321,339,348,361,457,481],"BMI":[72],"were":[77,194,226,365,415],"tested":[78,183,343,355],"for":[79,145,168,245,444],"association":[80,103,120,131,381],"AN,":[82,190,362,406],"both":[83,107,162],"an":[85],"individual":[86],"basis":[87],"as":[89,439,467],"combined":[91,287],"score":[92],"(a":[93],"so-called":[94],"polygenic":[95],"score).":[97],"There":[98],"was":[99,182,389,398],"no":[100,407],"evidence":[101,206],"scenarios.":[108],"We":[109,148,196,342],"also":[110],"studied":[111],"POMC":[115,141],"gene":[116],"locus":[117],"its":[119,403],"several":[122,184,291],"food":[125],"intake":[126],"phenotypes.":[128],"Signals":[129],"waist:hip":[133],"ratio,":[134],"visceral":[135],"fat":[136,139],"abdominal":[138],"made":[140],"strong":[143],"candidate":[144],"further":[146,149],"studies.":[147],"two":[152],"SNPs":[153,181,220,384],"located":[154],"BDNF":[157,301,317],"COMT":[159],"genes,":[160],"have":[163,336],"theoretical":[164],"empirical":[166],"support":[167],"playing":[169],"aetiology":[174],"psychiatric":[176,340,436],"disorders.":[177,341],"Each":[178],"those":[180,208],"times":[185],"previous":[187,209],"studies":[188,210,292],"but":[191],"results":[193,232,240],"inconsistent.":[195],"applied":[197],"meta-analytic":[199],"framework":[200],"evaluate":[202],"combine":[204],"from":[207,237,290,455],"our":[212],"own,":[213],"novel":[214],"data.":[215,257],"This":[216,311],"work":[217],"showed":[218,313],"that":[219,314,445,465],"rs6265":[221],"(BDNF)":[222,261],"rs4680":[224],"(COMT)":[225],"not":[227],"AN.":[230,284,310,458],"Our":[231],"resolve":[233],"controversy":[235],"stemming":[236],"prior":[238],"inconsistent":[239],"underlie":[242],"necessity":[244],"large":[246,330],"sample":[247,472],"sizes":[248,473],"stringent":[250],"quality":[251],"control":[252],"analysis":[254],"Brain-derived":[258],"neurotrophic":[259],"factor":[260],"belongs":[262],"family":[265],"neurotrophins":[267],"has":[269],"multiple":[270],"functions":[271],"theoretically":[274],"development":[280],"maintenance":[282],"Here,":[285],"we":[286],"data":[289],"performed":[294],"meta-analysis":[296],"levels":[299],"protein":[302],"blood":[305],"serum":[306,316],"patients":[308,320,456],"study":[312,382,401],"level":[318,414],"is":[323],"lower":[324],"than":[325],"healthy":[327],"controls.":[328],"Several":[329],"recurrent":[332],"copy-number":[333],"(CNVs)":[335],"been":[337],"preselected":[344],"CNVs":[345,356],"cases":[347],"versus":[350],"control.":[351],"None":[352],"appeared":[357],"be":[359,371,486],"although":[363],"there":[364],"important":[366],"caveats":[367],"needed":[369],"taken":[372],"into":[373],"account":[374],"when":[375,470],"interpreting":[376],"these":[377],"results.":[378],"A":[379],"genome-wide":[380,412],"controls":[388],"part":[390],"work.":[394],"Even":[395],"though":[396],"it":[397],"largest":[400],"kind":[404],"at":[410],"significance":[413],"found.":[416],"current":[418],"accomplishments":[419],"gene-association":[422],"are":[426,446],"more":[427],"modest,":[428],"compared":[429],"some":[434],"other":[435],"disorders,":[437],"such":[438],"schizophrenia.":[440],"main":[442],"reason":[443],"smaller":[448],"numbers":[449],"available":[452],"DNA":[453],"samples":[454],"architecture":[461],"suggest":[464],"(similarly":[466],"schizophrenia)":[469],"substantially,":[475],"new":[476],"loci":[477],"harbouring":[478],"susceptibility":[482],"will":[485],"determined.":[487]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}