{"id":"https://openalex.org/W2378863307","doi":null,"title":"Loss of Perivascular Aquaporin 4 and Inwardly Rectifying Potassium Channel 4.1 in Human Mesial Temporal Lobe Epilepsy","display_name":"Loss of Perivascular Aquaporin 4 and Inwardly Rectifying Potassium Channel 4.1 in Human Mesial Temporal Lobe Epilepsy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2378863307","mag":"2378863307"},"language":"en","primary_location":{"id":"mag:2378863307","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZKLS201203008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764517539","display_name":"Zhongguo kangfu lilun yu shijian","issn_l":"1006-9771","issn":["1006-9771"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4361729651","host_organization_name":"China Rehabilitation Research Center","host_organization_lineage":["https://openalex.org/P4361729651"],"host_organization_lineage_names":["China Rehabilitation Research Center"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo kangfu lilun yu shijian","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100601432","display_name":"Guilin Li","orcid":"https://orcid.org/0000-0001-8007-6096","observed_orcids":["https://orcid.org/0000-0001-8007-6096"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guilin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8007-6096","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100601432"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.105,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44457452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.164900004863739,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesial-temporal-lobe-epilepsy","display_name":"mesial temporal lobe epilepsy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kir4-1","display_name":"Kir4.1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/inwardly-rectifying-potassium-channels","display_name":"inwardly rectifying potassium channels","score":0.9350000023841858},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9580000042915344},{"id":"https://openalex.org/keywords/astrocyte-swelling","display_name":"astrocyte swelling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/astrocyte-hyperplasia","display_name":"astrocyte hyperplasia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8640000224113464},{"id":"https://openalex.org/keywords/astrocyte-dysfunction","display_name":"astrocyte dysfunction","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.765438437461853},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6373612880706787},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.6286981701850891},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5903668999671936},{"id":"https://openalex.org/C2994116697","wikidata":"https://www.wikidata.org/wiki/Q616667","display_name":"Mesial temporal lobe epilepsy","level":4,"score":0.5135776996612549},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4965682625770569},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4746147692203522},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4426915645599365},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.3644280433654785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34068095684051514},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31946173310279846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2580510973930359},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22572684288024902}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2378863307","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZKLS201203008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764517539","display_name":"Zhongguo kangfu lilun yu shijian","issn_l":"1006-9771","issn":["1006-9771"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4361729651","host_organization_name":"China Rehabilitation Research Center","host_organization_lineage":["https://openalex.org/P4361729651"],"host_organization_lineage_names":["China Rehabilitation Research Center"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo kangfu lilun yu shijian","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972464623","https://openalex.org/W4200585707","https://openalex.org/W2092912392","https://openalex.org/W2148048620","https://openalex.org/W2012665046","https://openalex.org/W2155769860","https://openalex.org/W2085600559","https://openalex.org/W7164196381","https://openalex.org/W3084155058","https://openalex.org/W2137420165"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,15,106,113],"distribution":[4,41],"of":[5,27,32,42,59,74,88,100,115],"aquaporin":[6],"4(AQP4)":[7],"and":[8,29,37,44,67,76,90,103],"inwardly":[9],"rectifying":[10],"potassium":[11],"channel":[12],"4.1(Kir4.1)":[13],"in":[14,46,92,97,105,117],"astrocytes":[16,47,66],"from":[17],"human":[18,107],"mesial":[19],"temporal":[20],"lobe":[21],"epilepsy(MTLE).Methods":[22],"Hippocampal":[23],"specimens,including":[24],"10":[25],"cases":[26,31],"MTLE":[28,60,108],"6":[30],"non-MTLE,were":[33],"observed":[34],"under":[35],"optical":[36],"transmission":[38],"electron":[39],"microscopy.The":[40],"AQP4":[43,75,89,102],"Kir4.1":[45,77,91,104],"was":[48],"investigated":[49],"with":[50,53],"immunoflurescence.Results":[51],"Compared":[52],"non-MTLE":[54,71],"hippocampus,the":[55],"main":[56],"structural":[57],"changes":[58],"included":[61],"remarkable":[62],"hyperplasia":[63],"astrocytes,serious":[64],"swelling":[65],"distinguished":[68],"astrophy":[69],"neurons.In":[70],"hippocampus,immunoflurescence":[72],"signals":[73],"were":[78],"enriched":[79],"along":[80],"perivascular":[81,93,101],"astrocyte":[82,94,116],"end-feet":[83,95],"domain.However,it":[84],"reveals":[85],"significant":[86],"loss":[87],"domain":[96],"MTLE.Conclusion":[98],"Loss":[99],"may":[109],"help":[110],"to":[111],"understand":[112],"roles":[114],"MTLE.":[118]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-20T06:17:55.931218","created_date":"2016-06-24T00:00:00"}