{"id":"https://openalex.org/W23779910","doi":null,"title":"[Relationship between RAR-beta gene expression defect and its methylation].","display_name":"[Relationship between RAR-beta gene expression defect and its methylation].","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W23779910","mag":"23779910","pmid":"https://pubmed.ncbi.nlm.nih.gov/17961338"},"language":"zh","primary_location":{"id":"pmid:17961338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17961338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004283841","display_name":"Yanping Gao","orcid":"https://orcid.org/0009-0002-7254-4480","observed_orcids":["https://orcid.org/0009-0002-7254-4480"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-ping Gao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101466958","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-2776-679X","observed_orcids":["https://orcid.org/0000-0002-2776-679X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103582672","display_name":"Yingying Zhang","orcid":"https://orcid.org/0009-0005-9614-0503","observed_orcids":["https://orcid.org/0009-0005-9614-0503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying-ying Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034356382","display_name":"Han Wang","orcid":"https://orcid.org/0000-0002-1933-5762","observed_orcids":["https://orcid.org/0000-0002-1933-5762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110905130","display_name":"Xiaohong He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-hong He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100396235","display_name":"Zehua Wang","orcid":"https://orcid.org/0000-0001-6423-8219","observed_orcids":["https://orcid.org/0000-0001-6423-8219","https://orcid.org/0009-0001-1879-7594"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ze-hua Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00261473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"7","first_page":"472","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rarbeta","display_name":"RAR\u03b2","score":0.7350000143051147},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-beta","display_name":"retinoic acid receptor beta","score":0.8289999961853027},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.7730000019073486},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/demethylation","display_name":"demethylation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.671999990940094},{"id":"https://openalex.org/keywords/siha-cells","display_name":"SiHa cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caski-cells","display_name":"CaSki cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/c33a-cells","display_name":"C33A cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6520000100135803},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.7881829738616943},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.755573570728302},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7424424886703491},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.665930986404419},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6362966299057007},{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.6046383380889893},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5591036081314087},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47067198157310486},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4489724040031433},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4121474623680115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40635576844215393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39388149976730347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08687072992324829},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05690169334411621}],"mesh":[{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17961338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17961338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua fu chan ke za zhi","raw_type":"English Abstract"},{"id":"mag:23779910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17961338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2517131087","https://openalex.org/W3029694692","https://openalex.org/W1861883318","https://openalex.org/W2076939478","https://openalex.org/W2370532941","https://openalex.org/W2054120792","https://openalex.org/W1978075575","https://openalex.org/W2165664170","https://openalex.org/W2382746886","https://openalex.org/W2253421696"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,21,28,45,71,89,210,319,338],"expression":[4,26,36,98,118,157,173,214,312,341],"of":[5,31,37,41,73,91,120,158,216,258,321,329,340,342],"RAR-beta":[6,32,42,74,92,96,121,159,185,199,217,259,310,330,343],"gene":[7,25,43,93,97,186,200,311,331],"in":[8,44,70,122,160,175,188,202,218,271,294,318,326],"cervical":[9,322],"carcinoma":[10],"cell":[11,47,86,103,123,165,177,193,204,224,276,296,306],"lines":[12,48,87,124,166,225,277],"SiHa,":[13,125,161,189,219,272],"HeLa,":[14,126,220,273],"C33A":[15,129,176,203,223,295],"and":[16,18,27,39,55,88,95,116,128,141,155,163,191,212,222,239,255,266,274,289],"Caski":[17,127,164,192,221,275],"to":[19,64,83],"analyze":[20],"relation":[22],"between":[23,264,287],"their":[24],"promoter":[29,72],"methylation":[30,69,94,187,201,325],"DNA.":[33],"METHODS:":[34],"The":[35,76,102,114,153,253,301,309],"mRNA":[38,115,154,211,254],"protein":[40,117,156,213,256],"four":[46],"were":[49,100,130,167,184,226],"analyzed":[50],"by":[51],"RT-PCR,":[52],"western":[53],"blot":[54],"immunofluorescence,":[56],"respectively.":[57,152,252],"Methylation":[58],"specific":[59],"PCR":[60],"(MSP)":[61],"was":[62,68,81,105,197],"used":[63,82],"check":[65],"whether":[66],"there":[67,183,196],"gene.":[75,344],"demethylating":[77],"agent":[78],"5-aza-2'-deoxycytidine":[79],"(5-Aza-cdR)":[80],"treat":[84],"methylated":[85],"change":[90],"defects":[99,313],"observed.":[101],"proliferation":[104],"assayed":[106],"with":[107,208,269,292],"3-(4,":[108],"5-dimethylthiazol-2-yl)-2,":[109],"5-diphenyltetrazolium":[110],"bromide":[111],"method.":[112],"RESULTS:":[113],"levels":[119,215,257],"0.25":[131],"+/-":[132,136,139,143,147,150,228,231,234,237,241,244,247,250],"0.08,":[133],"0,":[134,145],"0.60":[135],"0.19,":[137],"3.12":[138],"0.92":[140],"0.23":[142],"0.07,":[144],"0.14":[146],"0.05,":[148],"0.68":[149],"0.21,":[151,242],"HeLa":[162,190],"decreased":[168],"or":[169],"silenced,":[170],"whereas":[171],"its":[172],"increased":[174],"line.":[178,205],"MSP":[179],"method":[180],"showed":[181],"that":[182],"lines,":[194],"while":[195],"no":[198,284],"After":[206],"treated":[207],"5-Aza-cdR,":[209],"1.82":[227],"0.59,":[229],"2.13":[230],"0.62,":[232],"1.67":[233],"0.43,":[235],"2.95":[236],"0.89":[238],"0.69":[240],"0.83":[243],"0.29,":[245],"0.56":[246],"0.16,":[248],"0.64":[249],"0.20":[251],"had":[260,283],"a":[261],"significant":[262,285],"difference":[263,286],"before":[265,288],"after":[267,290],"interference":[268,291],"5-Aza-cdR":[270,293,302],"(P":[278,298],"<":[279],"0.05).":[280,300],"However,":[281],"they":[282],"line":[297],">":[299],"treatment":[303],"could":[304],"suppress":[305],"proliferation.":[307],"CONCLUSIONS:":[308],"play":[314],"an":[315,334],"important":[316,335],"role":[317],"carcinogenesis":[320],"cancer.":[323],"Aberrant":[324],"promotor":[327],"region":[328],"may":[332],"be":[333],"mechanism":[336],"for":[337],"loss":[339]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}