{"id":"https://openalex.org/W2377690331","doi":null,"title":"In vitro study of the synergistic effect of tetrandrine and fluconazole against Candida albicans","display_name":"In vitro study of the synergistic effect of tetrandrine and fluconazole against Candida albicans","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2377690331","mag":"2377690331"},"language":"en","primary_location":{"id":"mag:2377690331","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHPF200608008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764659248","display_name":"Chinese Journal of Dermatology","issn_l":"0412-4030","issn":["0412-4030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Dermatology","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071946240","display_name":"Zhang Hon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhang Hon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071946240"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.28460978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrandrine","display_name":"tetrandrine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/antifungal-synergy","display_name":"antifungal synergy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/fluconazole-resistance","display_name":"fluconazole resistance","score":0.7900000214576721},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8640000224113464},{"id":"https://openalex.org/keywords/combination-antifungal-therapy","display_name":"combination antifungal therapy","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2779934757","wikidata":"https://www.wikidata.org/wiki/Q7706612","display_name":"Tetrandrine","level":2,"score":0.9765150547027588},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.9301060438156128},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8304275274276733},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.7024218440055847},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5936893224716187},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5594661235809326},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.500831127166748},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49720075726509094},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.4597935378551483},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.42711713910102844},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42031562328338623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2979758381843567},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.28142452239990234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2705318331718445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09111583232879639}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2377690331","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHPF200608008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764659248","display_name":"Chinese Journal of Dermatology","issn_l":"0412-4030","issn":["0412-4030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Dermatology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1478152577","https://openalex.org/W2390420628","https://openalex.org/W2806315833","https://openalex.org/W2356480206","https://openalex.org/W2073755704","https://openalex.org/W2068173118","https://openalex.org/W2087436516","https://openalex.org/W2348564677","https://openalex.org/W960107024","https://openalex.org/W3029813041"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,11,63,78,89,103,112],"synergistic":[4],"effect":[5,31],"of":[6,13,55,66,71,85,95],"tetrandrine":[7,27,48,67,100],"and":[8,15,44,117],"fluconazole":[9,42,86,96,110],"on":[10,32],"growth":[12],"fluconazole-sensitive":[14,116],"-resistant":[16],"Candida":[17],"albicans":[18],"in":[19,45,97,111,121],"vitro.Methods":[20],"The":[21],"minimum":[22,39],"concentra-":[23],"tion":[24],"at":[25],"which":[26],"had":[28],"no":[29],"cytotoxic":[30],"C.albicans":[33,56,72,79,120],"was":[34,49,73],"determined":[35],"by":[36,57],"microdilution":[37,60],"test.The":[38],"inhibitory":[40],"concentration(MIC)of":[41],"alone":[43,87],"combination":[46,98],"with":[47,99,109],"de-":[50],"termined":[51],"against":[52,114],"16":[53],"strains":[54,80,91],"NCCLS":[58],"M27-A":[59],"method.Results":[61],"When":[62],"con-":[64],"centration":[65],"was\u226440\u03bcg/mL,the":[68],"survival":[69],"rate":[70],"greater":[74],"than":[75],"95%.Tetrandrine":[76],"(30\uff5e40\u03bcg/mL)inhibited":[77],"from":[81],"forming":[82],"hyphae.The":[83],"MICs":[84],"to":[88],"above":[90],"were":[92],"0.250\uff5e64\u03bcg/mL,while":[93],"those":[94],"(40\u03bcg/mL)were":[101],"0.125\uff5e16\u03bcg/mL,and":[102],"so-called\u201ctrailing\u201dphenomenon":[104],"disappeared.Conclusion":[105],"Tetrandrine":[106],"acts":[107],"synergistically":[108],"activity":[113],"both":[115],"-resis-":[118],"tant":[119],"vitro.":[122]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
