{"id":"https://openalex.org/W2377465425","doi":"https://doi.org/10.1186/s13062-016-0126-5","title":"Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals","display_name":"Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals","publication_year":2016,"publication_date":"2016-05-13","ids":{"openalex":"https://openalex.org/W2377465425","doi":"https://doi.org/10.1186/s13062-016-0126-5","mag":"2377465425","pmid":"https://pubmed.ncbi.nlm.nih.gov/27179769"},"language":"en","primary_location":{"id":"doi:10.1186/s13062-016-0126-5","doi":"https://doi.org/10.1186/s13062-016-0126-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-016-0126-5","pdf_url":"https://biologydirect.biomedcentral.com/track/pdf/10.1186/s13062-016-0126-5","source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biologydirect.biomedcentral.com/track/pdf/10.1186/s13062-016-0126-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068524661","display_name":"Sean Broce","orcid":"https://orcid.org/0000-0003-0527-9605","observed_orcids":["https://orcid.org/0000-0003-0527-9605"]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Broce","raw_affiliation_strings":["Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061407674","display_name":"Lisa E. Hensley","orcid":"https://orcid.org/0000-0003-1188-4342","observed_orcids":["https://orcid.org/0000-0003-1188-4342"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Hensley","raw_affiliation_strings":["NIAID, Ft Detrick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIAID, Ft Detrick, MD, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104133235","display_name":"Tomoharu Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316910977","display_name":"DuPont (United States)","ror":"https://ror.org/03g3m1w62","country_code":"US","type":"company","lineage":["https://openalex.org/I1316910977"]},{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoharu Sato","raw_affiliation_strings":["DuPont Industrial Biosciences, Palo Alto, CA, USA","Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DuPont Industrial Biosciences, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I1316910977"]},{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066247177","display_name":"Joshua Lehrer\u2010Graiwer","orcid":"https://orcid.org/0009-0006-1196-7307","observed_orcids":["https://orcid.org/0009-0006-1196-7307"]},"institutions":[{"id":"https://openalex.org/I4210117853","display_name":"Global Blood Therapeutics (United States)","ror":"https://ror.org/03cr60k70","country_code":"US","type":"company","lineage":["https://openalex.org/I4210117853"]},{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Lehrer-Graiwer","raw_affiliation_strings":["Global Blood Therapeutics, Inc, Palo Alto, CA, USA","Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Blood Therapeutics, Inc, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210117853"]},{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013528983","display_name":"Christian Essrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Essrich","raw_affiliation_strings":["Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085304299","display_name":"Katie J. Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156279","display_name":"Calspan-University of Buffalo Research Center","ror":"https://ror.org/05hb9gz45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210156279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie J. Edwards","raw_affiliation_strings":["CUBRC, Inc, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CUBRC, Inc, Buffalo, NY, USA","institution_ids":["https://openalex.org/I4210156279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027686592","display_name":"Jacqueline Pajda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102308","display_name":"Lifetech Scientific (China)","ror":"https://ror.org/00qw2t413","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210102308"]},{"id":"https://openalex.org/I4210118323","display_name":"Life Prediction Technologies (Canada)","ror":"https://ror.org/02y8r3y04","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210118323"]}],"countries":["CA","CN"],"is_corresponding":false,"raw_author_name":"Jacqueline Pajda","raw_affiliation_strings":["Life Technologies, Inc, Grand Island, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Technologies, Inc, Grand Island, NY, USA","institution_ids":["https://openalex.org/I4210102308","https://openalex.org/I4210118323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073749050","display_name":"Christopher J. Davis","orcid":"https://orcid.org/0000-0002-9613-928X","observed_orcids":["https://orcid.org/0000-0002-9613-928X"]},"institutions":[{"id":"https://openalex.org/I1299022934","display_name":"United States Department of Health and Human Services","ror":"https://ror.org/033jnv181","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934"]},{"id":"https://openalex.org/I2801182042","display_name":"Biomedical Advanced Research and Development Authority","ror":"https://ror.org/029y69023","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I2801182042"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Davis","raw_affiliation_strings":["Biomedical Advanced Research & Development Authority, Office of the Assistant Secretary of Preparedness & Response, U.S. Department of Health & Human Services, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Advanced Research & Development Authority, Office of the Assistant Secretary of Preparedness & Response, U.S. Department of Health & Human Services, Washington, DC, USA","institution_ids":["https://openalex.org/I1299022934","https://openalex.org/I2801182042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129683305","display_name":"Rami Bhadresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]},{"id":"https://openalex.org/I4210149349","display_name":"Syngene International (India)","ror":"https://ror.org/04k99et05","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210149349"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Rami Bhadresh","raw_affiliation_strings":["Biocon Bristol-Myers Squibb, Syngene International Ltd, Bangalore, India","Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocon Bristol-Myers Squibb, Syngene International Ltd, Bangalore, India","institution_ids":["https://openalex.org/I4210149349"]},{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070959242","display_name":"Clarence R. Hurt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clarence R. Hurt","raw_affiliation_strings":["Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038748737","display_name":"Beverly Freeman","orcid":"https://orcid.org/0009-0009-9489-2161","observed_orcids":["https://orcid.org/0009-0009-9489-2161"]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly Freeman","raw_affiliation_strings":["Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037677777","display_name":"Vishwanath R. Lingappa","orcid":"https://orcid.org/0000-0003-0962-6571","observed_orcids":["https://orcid.org/0000-0003-0962-6571"]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vishwanath R. Lingappa","raw_affiliation_strings":["Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113525213","display_name":"Colm A. Kelleher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133312","display_name":"Nano Hydrophobics (United States)","ror":"https://ror.org/02xejyg29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colm A. Kelleher","raw_affiliation_strings":["Bigelow Aerospace Advanced Space Studies, Las Vegas, NV, USA","Prosetta Antiviral Inc, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bigelow Aerospace Advanced Space Studies, Las Vegas, NV, USA","institution_ids":[]},{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA","institution_ids":["https://openalex.org/I4210133312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069745813","display_name":"Marcela Viviana Karpuj","orcid":"https://orcid.org/0000-0002-2209-2175","observed_orcids":["https://orcid.org/0000-0002-2209-2175"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I4210156279","display_name":"Calspan-University of Buffalo Research Center","ror":"https://ror.org/05hb9gz45","country_code":"US","type":"education","lineage":["https://openalex.org/I4210156279"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Marcela V. Karpuj","raw_affiliation_strings":["BioA2Z, Inc, San Francisco, CA, USA. mvkarpuj@bioa2z.com","CUBRC, Inc, Buffalo, NY, USA. mvkarpuj@bioa2z.com","Faculty of Medicine, Bar-Ilan University, 8 Henrietta Szold, Safed, 1311502, Israel. mvkarpuj@bioa2z.com","Prosetta Antiviral Inc, San Francisco, CA, USA. mvkarpuj@bioa2z.com","CUBRC, Inc, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioA2Z, Inc, San Francisco, CA, USA. mvkarpuj@bioa2z.com","institution_ids":[]},{"raw_affiliation_string":"CUBRC, Inc, Buffalo, NY, USA. mvkarpuj@bioa2z.com","institution_ids":["https://openalex.org/I4210156279"]},{"raw_affiliation_string":"Faculty of Medicine, Bar-Ilan University, 8 Henrietta Szold, Safed, 1311502, Israel. mvkarpuj@bioa2z.com","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Prosetta Antiviral Inc, San Francisco, CA, USA. mvkarpuj@bioa2z.com","institution_ids":[]},{"raw_affiliation_string":"CUBRC, Inc, Buffalo, NY, USA","institution_ids":["https://openalex.org/I4210156279"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5069745813"],"corresponding_institution_ids":["https://openalex.org/I13955877","https://openalex.org/I4210156279"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.5601,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.719853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"1","first_page":"25","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rift-valley-fever-virus","display_name":"Rift Valley fever virus","score":1.0},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.7160000205039978},{"id":"https://openalex.org/keywords/capsid-assembly","display_name":"capsid assembly","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antiviral-drug-screening","display_name":"antiviral drug screening","score":0.8100000023841858},{"id":"https://openalex.org/keywords/wheat-germ-extract","display_name":"wheat germ extract","score":0.6980000138282776},{"id":"https://openalex.org/keywords/transcription-and-translation","display_name":"transcription and translation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.9599999785423279},{"id":"https://openalex.org/keywords/capsid-structure","display_name":"capsid structure","score":0.7639999985694885},{"id":"https://openalex.org/keywords/viral-countermeasures","display_name":"viral countermeasures","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9120951890945435},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.742573618888855},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.7368111610412598},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6919634342193604},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.6508803963661194},{"id":"https://openalex.org/C2778960357","wikidata":"https://www.wikidata.org/wiki/Q326638","display_name":"Rift Valley fever","level":3,"score":0.6381317377090454},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5338692665100098},{"id":"https://openalex.org/C2778116200","wikidata":"https://www.wikidata.org/wiki/Q630622","display_name":"Arbovirus","level":3,"score":0.4886086583137512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19411513209342957}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012296","descriptor_name":"Rift Valley fever virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012296","descriptor_name":"Rift Valley fever virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012296","descriptor_name":"Rift Valley fever virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012296","descriptor_name":"Rift Valley fever virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13062-016-0126-5","doi":"https://doi.org/10.1186/s13062-016-0126-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-016-0126-5","pdf_url":"https://biologydirect.biomedcentral.com/track/pdf/10.1186/s13062-016-0126-5","source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"},{"id":"pmid:27179769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27179769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology direct","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4867995","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4867995","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biol Direct","raw_type":"Text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0r91f2wh","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0r91f2wh","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:qt0r91f2wh","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/0r91f2wh","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lingappa, Vishwanath; Broce, S; Hensley, L; Sato, T; Lehrer-Graiwer, J; Essrich, C; \u00c2\u00a0et al.(2016). Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0r91f2wh","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13062-016-0126-5","doi":"https://doi.org/10.1186/s13062-016-0126-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-016-0126-5","pdf_url":"https://biologydirect.biomedcentral.com/track/pdf/10.1186/s13062-016-0126-5","source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4589795325","display_name":null,"funder_award_id":"Contract No. HDTRA1-06-C-0028.","funder_id":"https://openalex.org/F4320332186","funder_display_name":"Defense Threat Reduction Agency"},{"id":"https://openalex.org/G7739926629","display_name":null,"funder_award_id":"27302C0028","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2377465425.pdf","grobid_xml":"https://content.openalex.org/works/W2377465425.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W4177936","https://openalex.org/W200105130","https://openalex.org/W569951484","https://openalex.org/W1977151278","https://openalex.org/W1977660380","https://openalex.org/W1979236771","https://openalex.org/W2007418972","https://openalex.org/W2020357764","https://openalex.org/W2030746098","https://openalex.org/W2035760671","https://openalex.org/W2046821199","https://openalex.org/W2047267761","https://openalex.org/W2050739438","https://openalex.org/W2051504973","https://openalex.org/W2067820449","https://openalex.org/W2115451854","https://openalex.org/W2120031060","https://openalex.org/W2120034417","https://openalex.org/W2129549132","https://openalex.org/W2129587821","https://openalex.org/W2134294929","https://openalex.org/W2136057221","https://openalex.org/W2143943017","https://openalex.org/W2147282955","https://openalex.org/W2155754702","https://openalex.org/W2161903988","https://openalex.org/W2181908191"],"related_works":["https://openalex.org/W2207673543","https://openalex.org/W2077986276","https://openalex.org/W2065199367","https://openalex.org/W4309528855","https://openalex.org/W2900078974","https://openalex.org/W2105528824","https://openalex.org/W4221072037","https://openalex.org/W2064379354","https://openalex.org/W1965958028","https://openalex.org/W2471913697"],"abstract_inverted_index":{"BACKGROUND:":[0],"Viral":[1],"capsid":[2,9,115,158],"assembly":[3,105,177],"involves":[4],"the":[5,8,57,64,79,85,100,108,127,150,172,182,201,207],"oligomerization":[6,148],"of":[7,66,88,99,129,154,175,184],"nucleoprotein":[10,147],"(NP),":[11],"which":[12,145],"is":[13],"an":[14],"essential":[15],"step":[16],"in":[17,28,38,101,181,188],"viral":[18,165],"replication":[19],"and":[20,96,112,167,178,197],"may":[21],"represent":[22],"a":[23,33,41,74,89,123,155,189],"potential":[24,130,185],"antiviral":[25,54,131,186],"target.":[26],"An":[27],"vitro":[29],"transcription-translation":[30],"reaction":[31],"using":[32],"wheat":[34],"germ":[35],"(WG)":[36],"extract":[37],"combination":[39],"with":[40,53,71,73,149],"sandwich":[42],"ELISA":[43],"assay":[44],"has":[45],"recently":[46],"been":[47],"used":[48,120,168],"to":[49,69,121,163,170,179,206],"identify":[50],"small":[51],"molecules":[52],"activity":[55],"against":[56],"rabies":[58],"virus.":[59],"RESULTS:":[60],"Here,":[61],"we":[62],"examined":[63],"application":[65],"this":[67,141],"system":[68],"viruses":[70],"capsids":[72],"different":[75],"structure,":[76,159],"such":[77],"as":[78],"Rift":[80],"Valley":[81],"fever":[82],"virus":[83],"(RVFV),":[84],"etiological":[86],"agent":[87],"severe":[90],"emerging":[91],"infectious":[92],"disease.":[93],"The":[94],"biochemical":[95],"immunological":[97],"characterization":[98],"vitro-generated":[102],"RVFV":[103,134],"NP":[104,176],"products":[106],"enabled":[107],"distinction":[109,118],"between":[110],"intermediately":[111],"highly":[113,156],"ordered":[114,157],"structures.":[116],"This":[117],"was":[119],"establish":[122],"screening":[124],"method":[125],"for":[126,133],"identification":[128,183],"drugs":[132,187],"countermeasures.":[135],"CONCLUSIONS:":[136],"These":[137],"results":[138],"indicated":[139],"that":[140],"unique":[142],"analytical":[143],"system,":[144],"combines":[146],"specific":[151],"immune":[152],"recognition":[153],"can":[160],"be":[161],"extended":[162],"various":[164],"families":[166],"both":[169],"study":[171],"early":[173],"stages":[174],"assist":[180],"cost-efficient":[190],"manner.":[191],"REVIEWERS:":[192],"Reviewed":[193],"by":[194],"Jeffry":[195],"Skolnick":[196],"Noah":[198],"Isakov.":[199],"For":[200],"full":[202],"reviews":[203],"please":[204],"go":[205],"Reviewers'":[208],"comments":[209],"section.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
