{"id":"https://openalex.org/W2377396155","doi":null,"title":"Promoting effect of statin on the growth of vessel-like structure","display_name":"Promoting effect of statin on the growth of vessel-like structure","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2377396155","mag":"2377396155"},"language":"en","primary_location":{"id":"mag:2377396155","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SHYX200510017.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764609275","display_name":"Shanghai yixue","issn_l":"0253-9934","issn":["0253-9934"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323294652","host_organization_name":"Shanghai Medical Association","host_organization_lineage":["https://openalex.org/P4323294652"],"host_organization_lineage_names":["Shanghai Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shanghai yixue","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079799092","display_name":"QI Guo-xia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"QI Guo-xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079799092"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20284813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pitavastatin","display_name":"pitavastatin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":1.0},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.9169999957084656},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/fibroblast-co-culture","display_name":"fibroblast co-culture","score":0.796999990940094},{"id":"https://openalex.org/keywords/luminal-area","display_name":"luminal area","score":0.5519999861717224},{"id":"https://openalex.org/keywords/vegf-receptor-2","display_name":"VEGF receptor 2","score":0.41600000858306885},{"id":"https://openalex.org/keywords/vegf-receptor-1","display_name":"VEGF receptor 1","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C2776692505","wikidata":"https://www.wikidata.org/wiki/Q412677","display_name":"Pitavastatin","level":3,"score":0.9334886074066162},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8329918384552002},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7730845212936401},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5618896484375},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.554955244064331},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5399565100669861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158747434616089},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.5130699872970581},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4709131419658661},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4170922636985779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4006495177745819},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3739059567451477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3649486303329468},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3524770736694336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2830311059951782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22368445992469788},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1711517870426178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16724592447280884},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14504370093345642},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2377396155","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-SHYX200510017.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764609275","display_name":"Shanghai yixue","issn_l":"0253-9934","issn":["0253-9934"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323294652","host_organization_name":"Shanghai Medical Association","host_organization_lineage":["https://openalex.org/P4323294652"],"host_organization_lineage_names":["Shanghai Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Shanghai yixue","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2379650524","https://openalex.org/W2051672717","https://openalex.org/W1992067276","https://openalex.org/W2092615804","https://openalex.org/W2094550436","https://openalex.org/W1985016499","https://openalex.org/W2355305552","https://openalex.org/W2264726489","https://openalex.org/W4389033852","https://openalex.org/W2062235476"],"abstract_inverted_index":{"Objective":[0],"To":[1],"observe":[2],"the":[3,8,14,28,69,91,106,112,121,125,128,131,133,136,138,146,154,159,170,185,193,197,208,216,221,233,237,240,243,264,275,292,298,315],"influence":[4],"of":[5,10,17,31,34,36,71,124,130,135,140,161,172,215,223,227,235,239,245,277,284,294,300,314,317],"Statins":[6,32,290,305],"on":[7],"growth":[9,293],"vessel-like":[11,72,126,186,217,295],"structure":[12,218,296],"and":[13,25,42,79,90,110,143,158,196,232,242,297,312],"cytokines\u2032":[15],"expression":[16,160,276,299],"cultivated":[18,303],"human":[19],"umbilical":[20],"vessel":[21,141,246],"endothelial":[22],"cells":[23,107],"(HUVEC),":[24],"to":[26,119],"test":[27],"pro-angiogenesis":[29,308],"effect":[30,309,316],"independent":[33,313],"regulation":[35],"blood":[37,318],"lipids.":[38],"Methods":[39],"The":[40,212,268],"HUVECs":[41,155,280],"fibroblasts":[43],"were":[44,156,188],"co-cultured":[45],"with":[46,81,145,152,207,220,263,310],"1\u00d710":[47,57,173,181,228,250,285],"-8\uff5e1\u00d710":[48,286],"-10":[49,174,230,251],"mol/ml":[50,54,175,178,183,252,288],"Pitavastatin\u30011\u00d710":[51,176],"-6\uff5e1\u00d710":[52],"-8":[53],"Atorvastatin":[55,179],"or":[56,180],"-5\uff5e1\u00d710":[58],"-7mol/ml":[59],"Provastatin":[60],"in":[61,74,95,192,225,279,302],"multiple":[62],"6":[63],"pores":[64],"Petri":[65],"dish.":[66],"And":[67],"then":[68,111],"number":[70,139,244],"structures":[73,187],"each":[75],"pore":[76],"was":[77,103,117,163,203,254,259],"calculated":[78],"compared":[80,144,206,262],"negative":[82,194],"control":[83,87,148,195,210,266],"(DMSO)":[84],"group,":[85,199],"positive":[86,147,209,265],"(VEGF)":[88],"group":[89],"angiogenesis-antagonist":[92,198],"group.":[93,149,211,267],"Pitavastatin":[94,224,253],"a":[96],"serial":[97],"concentrations":[98,226],"(1\u00d710":[99],"-10\uff5e1\u00d710":[100],"-13":[101],"mol/ml)":[102],"added":[104],"into":[105],"co-culture":[108],"system,":[109],"quantitative":[113],"angiogenesis":[114],"analysis":[115],"software":[116],"used":[118],"calculate":[120],"luminal":[122,213],"area":[123,214],"structure,":[127],"length":[129,234],"lumen,":[132,236],"crossing-point":[134,238],"vessels,":[137],"branches":[142,247],"After":[150],"treatment":[151,222],"Pitavastatin,":[153],"collected":[157],"VEGF":[162,278,301],"assessed":[164],"by":[165],"western":[166,271],"blot.":[167],"Results":[168],"Under":[169],"conditions":[171],"-6":[177],"-5":[182],"Provastatin,":[184],"more":[189],"than":[190],"that":[191,274],"no":[200,256],"significant":[201,257],"difference":[202,258],"seen":[204,260],"as":[205,261],"increased":[219,248],"-11\uff5e1\u00d710":[229],"mol/ml,":[231],"vessels":[241],"when":[249],"added,":[255],"results":[269],"from":[270],"blot":[272],"implied":[273],"augmented":[281],"under":[282],"circumstances":[283],"-12":[287],"Pitavastatin.Conclusions":[289],"induce":[291],"HUVECs.":[304],"may":[306],"have":[307],"dose-dependent":[311],"lipid":[319],"regulation.":[320]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}