{"id":"https://openalex.org/W2376982193","doi":null,"title":"Protective Effect of Mangiferin on Kidney in Diabetic Rats","display_name":"Protective Effect of Mangiferin on Kidney in Diabetic Rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2376982193","mag":"2376982193"},"language":"en","primary_location":{"id":"mag:2376982193","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-KDYZ201012011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764612545","display_name":"Chinese Journal of Arteriosclerosis","issn_l":"1007-3949","issn":["1007-3949"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4353108606","host_organization_name":"Chinese Society of Pathophysiology","host_organization_lineage":["https://openalex.org/P4353108606"],"host_organization_lineage_names":["Chinese Society of Pathophysiology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Arteriosclerosis","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019370827","display_name":"Shui Qiu","orcid":"https://orcid.org/0000-0001-5539-3321","observed_orcids":["https://orcid.org/0000-0001-5539-3321"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shui Qiu","raw_affiliation_strings":["-Jing1,LIU Yi1,and DU Hong-Yu2"],"raw_orcid":"https://orcid.org/0000-0001-5539-3321","affiliations":[{"raw_affiliation_string":"-Jing1,LIU Yi1,and DU Hong-Yu2","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019370827"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52044553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13846","display_name":"Mangiferin and Mango Extracts","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mangiferin","display_name":"mangiferin","score":1.0},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":1.0},{"id":"https://openalex.org/keywords/renal-hypertrophy","display_name":"renal hypertrophy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/urine-protein","display_name":"urinary protein","score":0.7239999771118164},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2777781930","wikidata":"https://www.wikidata.org/wiki/Q1074417","display_name":"Mangiferin","level":2,"score":0.8940463066101074},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.8430159091949463},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7595394253730774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7369313836097717},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6789218187332153},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6697294116020203},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.6567519903182983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6535992622375488},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.522229790687561},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.44998785853385925},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4450899660587311},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11834847927093506}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2376982193","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-KDYZ201012011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764612545","display_name":"Chinese Journal of Arteriosclerosis","issn_l":"1007-3949","issn":["1007-3949"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4353108606","host_organization_name":"Chinese Society of Pathophysiology","host_organization_lineage":["https://openalex.org/P4353108606"],"host_organization_lineage_names":["Chinese Society of Pathophysiology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Arteriosclerosis","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2141262645","https://openalex.org/W1916263719","https://openalex.org/W3028562336","https://openalex.org/W1966623127","https://openalex.org/W7098346363","https://openalex.org/W1981550821","https://openalex.org/W3003266517","https://openalex.org/W2350041295","https://openalex.org/W878926699","https://openalex.org/W2260809410"],"abstract_inverted_index":{"Aim":[0],"To":[1],"investigate":[2],"the":[3,15,36,84,117,135,190],"therapeutic":[4],"effects":[5],"of":[6,48,54,70,86,92,106,122,139,155,172,185,192],"mangiferin":[7,49,150],"on":[8,183],"experimental":[9],"diabetic":[10,20,40,118,136,178,186],"nephropathy":[11],"in":[12,95,116,149],"rats,and":[13],"explore":[14],"underlying":[16],"mechanism.":[17],"Methods":[18],"The":[19,170],"rats":[21,29,187],"was":[22,72,131,164],"induced":[23],"by":[24,74],"intraperitoneal":[25],"injection":[26],"with":[27,100,134],"streptozotocin(STZ).The":[28],"were":[30,64,80,113,126,146,159],"randomly":[31],"divided":[32],"into":[33],"five":[34],"groups:":[35],"normal":[37,101],"control":[38,102],"group,the":[39,42,103],"model":[41],"low(15":[43],"mg/(kg\u00b7d)),middle(30":[44],"mg/(kg\u00b7d)),high(60":[45],"mg/(kg\u00b7d))":[46],"doses":[47],"therapy":[50,151],"group.Renal":[51],"weight,index":[52],"number":[53,105,138],"kidney":[55,71,107,140,184],"hypertrophy,fasting":[56],"blood":[57],"glucose":[58],"and":[59,77,109,124,142,157],"24-hour":[60,110,143],"urinary":[61,111,144],"protein":[62,112,120,145,153],"excretion":[63],"examined":[65],"at":[66],"12":[67],"weeks.The":[68],"structure":[69],"analyzed":[73],"light":[75],"microscope.Immunohistochemistry":[76],"Western":[78],"Blotting":[79],"used":[81],"to":[82,177],"detect":[83],"expression":[85,121,154,171],"transforming":[87],"growing":[88],"factor-\u03b2(TGF-\u03b2),matrix":[89],"metalloproteinases-2(MMP-2),tissue":[90],"inhibitors":[91],"matrix":[93],"metalloproteinase-2(TIMP-2)":[94],"renal":[96],"tissues.":[97],"Results":[98],"Compared":[99],"index":[104],"hypertrophy":[108,141],"significantly":[114,127,132,147,160,165],"up-regulated":[115,128],"group;the":[119],"TGF-\u03b2":[123,156],"TIMP-2":[125,158],"while":[129],"MMP-2":[130],"decreased.Compared":[133],"group,index":[137],"decreased":[148],"groups(P0.01);the":[152],"decreased(P0.05":[161],"or":[162,167],"P0.01),MMP-2":[163],"up-regulated(P0.05":[166],"P0.01).":[168],"Conclusion":[169],"TGF-\u03b2,MMP-2":[173],"andTIMP-2":[174],"are":[175],"related":[176],"nephropathy(DN),mangiferin":[179],"has":[180],"protective":[181],"effect":[182],"through":[188],"affecting":[189],"changes":[191],"above":[193],"mentioned":[194],"indexes.":[195]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-06-24T00:00:00"}
