{"id":"https://openalex.org/W2376719540","doi":null,"title":"[Effects of different interventional modalities on vascular endothelial dysfunction of obese rats].","display_name":"[Effects of different interventional modalities on vascular endothelial dysfunction of obese rats].","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2376719540","mag":"2376719540","pmid":"https://pubmed.ncbi.nlm.nih.gov/17083792"},"language":"zh","primary_location":{"id":"pmid:17083792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17083792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er ke za zhi = Chinese journal of pediatrics","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100394235","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0001-6449-8838","observed_orcids":["https://orcid.org/0000-0001-6449-8838"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Department Pediatric of Shandong Provincial Hospital, Shandong University, Jinan 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Pediatric of Shandong Provincial Hospital, Shandong University, Jinan 250014, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058075739","display_name":"Yan Li","orcid":"https://orcid.org/0000-0003-2145-2869","observed_orcids":["https://orcid.org/0000-0003-2145-2869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112250386","display_name":"Shuzhen Sun","orcid":"https://orcid.org/0000-0001-8514-7113","observed_orcids":["https://orcid.org/0000-0001-8514-7113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu-zhen Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049560731","display_name":"Yonghui Yu","orcid":"https://orcid.org/0000-0003-0067-9028","observed_orcids":["https://orcid.org/0000-0003-0067-9028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong-hui Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418044","display_name":"Yulin Wang","orcid":"https://orcid.org/0000-0002-5934-4014","observed_orcids":["https://orcid.org/0000-0002-5934-4014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-lin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053966333","display_name":"Xiaohui Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-hui Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2284,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6330751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"8","first_page":"607","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9509999752044678},{"id":"https://openalex.org/keywords/swimming-training","display_name":"swimming training","score":0.7390000224113464},{"id":"https://openalex.org/keywords/sulfated-polysaccharides","display_name":"sulfated polysaccharides","score":0.906000018119812},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.4909999966621399},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.878000020980835},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.75},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.968999981880188},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/arterial-endothelium","display_name":"arterial endothelium","score":0.7429999709129333},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6460000276565552},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7821671366691589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7042276859283447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6826294660568237},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6157875657081604},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5957679748535156},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.544951319694519},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49620991945266724},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4921931326389313},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.4432673752307892},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.41089364886283875},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17083792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17083792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua er ke za zhi = Chinese journal of pediatrics","raw_type":"Comparative Study"},{"id":"mag:2376719540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17083792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2348509066","https://openalex.org/W2397814752","https://openalex.org/W4225130158","https://openalex.org/W2133208340","https://openalex.org/W3173230887","https://openalex.org/W2097749927","https://openalex.org/W3175695496","https://openalex.org/W2121071210","https://openalex.org/W2049742369","https://openalex.org/W4294957942"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"observe":[2],"the":[3,24,46,77,127,168,184,189,244,266],"effect":[4],"of":[5,19,85,90,94,102,107,114,124,129,154,171,191,206,262,278],"diet-control":[6,8,86,95,108,254,279],"only,":[7],"with":[9,13,96,109,250,255,280],"swimming":[10,97,251,281],"training":[11,98,252],"or":[12],"polysaccharide":[14],"sulfate":[15],"(PSS),":[16],"a":[17,242],"kind":[18],"blood":[20],"lipid-lowering":[21],"drug":[22],"on":[23,282],"serum":[25,132,192,230],"lipid":[26],"level":[27],"and":[28,70,104,144,167,195,215,222,246,253,264,273],"vascular":[29,247,268,283],"endothelial":[30,269,284],"function":[31,285],"in":[32,159,198,219,236,259],"obese":[33],"rats":[34,41,78,118,263],"fed":[35],"by":[36,164,175],"fat-rich-diet.":[37],"METHODS:":[38],"Forty":[39],"Wistar":[40],"were":[42,79,119,149,286],"randomly":[43],"divided":[44],"into":[45],"following":[47],"5":[48],"groups:":[49],"group":[50,55,60,65,71,199,220,237],"F":[51],"(n":[52,57,62,67,73],"=":[53,58,63,68,74],"8),":[54,59,64,75],"N":[56],"A":[61,200],"B":[66,221],"8)":[69],"C":[72,223],"where":[76],"given":[80],"fat-rich-diet,":[81,91,115],"basic-diet,":[82],"12":[83,92,105,122,187],"weeks":[84,89,93,101,106,113,123],"after":[87,99,111,121],"8":[88,100,112],"fat-rich-diet":[103],"PSS":[110,256],"respectively.":[116],"All":[117],"sacrificed":[120],"intervention.":[125],"Then":[126],"levels":[128,190,205],"Lee":[130,207],"index,":[131,208],"total":[133],"cholesterol":[134],"(TC),":[135],"triglyceride":[136],"(TG),":[137],"plasma":[138],"endothelin":[139],"(ET),":[140],"nitric":[141],"oxide":[142],"(NO)":[143],"von":[145],"Willebrand":[146],"Factor":[147],"(vWF)":[148],"measured.":[150],"The":[151,204,276],"protein":[152,214],"expression":[153,170],"intercellular":[155],"adhesion":[156],"molecule-1":[157],"(ICAM-1)":[158],"artery":[160],"endothelium":[161],"was":[162,173],"evaluated":[163],"immunohistochemistry":[165],"(IHC)":[166],"gene":[169],"ICAM-1":[172,213,216],"examined":[174],"semi-quantitative":[176],"reverse":[177],"transcription-polymerase":[178],"chain":[179],"reaction":[180],"(RT-PCR).":[181],"RESULTS:":[182],"After":[183],"interventions":[185,228],"for":[186],"weeks,":[188],"TC,":[193,209],"TG":[194],"ET":[196],"decreased":[197,218],"(P":[201,224,233],"<":[202,225,234],"0.05).":[203,226],"TG,":[210],"ET,":[211],"vWF,":[212],"mRNA":[217],"Three":[227],"increased":[229],"NO":[231],"production":[232],"0.05)":[235],"B.":[238],"CONCLUSIONS:":[239],"Diet-control":[240,249],"could":[241,257],"meliorate":[243,265],"hyperlipidemia":[245],"function.":[248],"result":[258],"weight":[260],"loss":[261],"hyperlipidemia,":[267],"function,":[270],"coagulatory":[271],"activities":[272],"adhesive":[274],"dysfunction.":[275],"effects":[277],"prominent.":[287]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}