{"id":"https://openalex.org/W2376710029","doi":null,"title":"Advances research in chromatin DNaseI hypersensitive sites and its transcriptional regulation function","display_name":"Advances research in chromatin DNaseI hypersensitive sites and its transcriptional regulation function","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2376710029","mag":"2376710029"},"language":"en","primary_location":{"id":"mag:2376710029","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB201506024.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003345393","display_name":"YU Wen-q","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"YU Wen-q","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Capital Medical University","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003345393"],"corresponding_institution_ids":["https://openalex.org/I183519381"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14880457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.9670000076293945},{"id":"https://openalex.org/keywords/chromatin","display_name":"chromatin","score":0.718999981880188},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dnase-seq","display_name":"DNase-seq","score":0.9200000166893005},{"id":"https://openalex.org/keywords/genome-wide-mapping","display_name":"genome-wide mapping","score":0.7770000100135803},{"id":"https://openalex.org/keywords/regulatory-elements","display_name":"regulatory elements","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.9462326765060425},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.6654402613639832},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.604362428188324},{"id":"https://openalex.org/C182614070","wikidata":"https://www.wikidata.org/wiki/Q17119065","display_name":"DNase I hypersensitive site","level":5,"score":0.5321637392044067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.525668203830719},{"id":"https://openalex.org/C58237431","wikidata":"https://www.wikidata.org/wiki/Q5958570","display_name":"Hypersensitive site","level":5,"score":0.5225754976272583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4953280985355377},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49377331137657166},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.484150230884552},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.4726630449295044},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.40294861793518066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3691500723361969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3639943301677704},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.3469342589378357},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2354225516319275},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.07085904479026794}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2376710029","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-JLYB201506024.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764879260","display_name":"Yixue yanjiusheng xuebao","issn_l":"1008-8199","issn":["1008-8199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361729665","host_organization_name":"Nanjing General of Nanjing Military Region","host_organization_lineage":["https://openalex.org/P4361729665"],"host_organization_lineage_names":["Nanjing General of Nanjing Military Region"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Yixue yanjiusheng xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804049357","https://openalex.org/W2122818453","https://openalex.org/W2412548558","https://openalex.org/W1964963969","https://openalex.org/W2964717004","https://openalex.org/W2884951082","https://openalex.org/W7098909439","https://openalex.org/W138260553","https://openalex.org/W1542952446","https://openalex.org/W1562426635"],"abstract_inverted_index":{"DNase\u2160":[0],"hypersensitive":[1],"sites(":[2],"DHSs)":[3],"are":[4],"regions":[5],"of":[6,27,46,54,57,67],"extreme":[7],"chromatin":[8],"which":[9],"is":[10,18],"highly":[11],"sensitive":[12],"to":[13],"DNase\u2160.":[14],"Genome-wide":[15],"mapping":[16],"DHSs":[17],"a":[19],"powerful":[20],"method":[21],"for":[22],"identifying":[23],"many":[24],"different":[25],"types":[26],"regulatory":[28],"elements":[29],"within":[30],"nuclear":[31],"chromatin.":[32],"It":[33],"can":[34],"help":[35],"systematically":[36],"resolve":[37],"gene":[38],"and":[39,59],"genomic":[40],"information,and":[41],"the":[42,52,60],"dynamic":[43],"molecular":[44],"mechanism":[45],"transcriptional":[47,64],"regulation.":[48],"This":[49],"paper":[50],"reviews":[51],"distribution":[53],"DHSs,the":[55],"technology":[56],"DNase-seq":[58],"research":[61],"progress":[62],"in":[63],"regulation":[65],"functions":[66],"DHSs.":[68]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}