{"id":"https://openalex.org/W2376656442","doi":null,"title":"Abnormality of VHL gene and VEGF expression in primary renal cell carcinoma","display_name":"Abnormality of VHL gene and VEGF expression in primary renal cell carcinoma","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2376656442","mag":"2376656442"},"language":"en","primary_location":{"id":"mag:2376656442","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHMN200110002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764971217","display_name":"Zhonghua miniao waike zazhi","issn_l":"1000-6702","issn":["1000-6702"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua miniao waike zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0001-6939-7905","observed_orcids":["https://orcid.org/0000-0001-6939-7905"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jie Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6939-7905","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32200216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/vhl-gene","display_name":"VHL gene","score":0.9750000238418579},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.9049999713897705},{"id":"https://openalex.org/keywords/vhl-mutation","display_name":"VHL mutation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7049999833106995},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.9919999837875366},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.7174180746078491},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6328593492507935},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6015496850013733},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5704928040504456},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5106728672981262},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.4873131215572357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43102163076400757},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4235297441482544},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3607001304626465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.344002366065979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2151619791984558},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2376656442","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHMN200110002.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764971217","display_name":"Zhonghua miniao waike zazhi","issn_l":"1000-6702","issn":["1000-6702"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua miniao waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2347880680","https://openalex.org/W2282932138","https://openalex.org/W2038781838","https://openalex.org/W2084522805","https://openalex.org/W2062957198","https://openalex.org/W3081397151","https://openalex.org/W2793746618","https://openalex.org/W4248132665","https://openalex.org/W2029126579","https://openalex.org/W2610355462"],"abstract_inverted_index":{"Objective":[0],"To":[1],"evaluate":[2],"the":[3,32,55,83,91,98,103,126,131,137,143,148,150,155,166,182,190,204],"significance":[4],"of":[5,9,27,34,40,48,62,71,97,108,130,140,147,158,168,184,192,208],"t":[6],"he":[7],"abnormality":[8,167,175],"VHL":[10,28,72,169,172],"gene":[11,73],"and":[12,24,31,43,58,88,95,123,128,145,186,206],"VEGF":[13,35,109,159,193],"expression":[14,33,160,191],"in":[15,45,59,76,82,112,117,181,194],"primary":[16,49,195],"renal":[17,64,85,119],"cell":[18],"carcinoma":[19],"(":[20],"RCC).":[21],"Methods":[22],"Mutation":[23],"abnormal":[25],"methylation":[26],"g":[29],"ene":[30],"were":[36],"dtected":[37],"by":[38],"means":[39],"multiplex":[41],"PCR,PCR-SSCP":[42],"immunohistochemistry":[44],"42":[46],"cases":[47],"RCC,in":[50],"18":[51],"specimens":[52,61],"adjacent":[53],"to":[54],"neoplastic":[56],"lesion":[57],"10":[60],"normal":[63,84,118],"tissues.":[65],"R":[66],"esults":[67],"The":[68],"alteration":[69],"rate":[70,157],"was":[74,110],"higher":[75,111,142],"RCC":[77,113,185],"tissue":[78,86,114,120],"(61.":[79],"9%)":[80],"than":[81,116],"(3.6%,P0.005)":[87],"correlated":[89,124,162],"with":[90,102,125,165],"p":[92],"athological":[93],"type":[94,139],"stage":[96,129,146],"tumor":[99,132,149],"but":[100,133],"not":[101,134],"grade.The":[104],"positive":[105,156],"r":[106],"ate":[107],"(64.29%)":[115],"(21.4":[121],"%,P0.005)":[122],"grade":[127,144],"wit":[135],"h":[136,151],"pathological":[138],"RCC.The":[141],"igher":[152],"would":[153],"be":[154],"which":[161],"significant":[163,179],"ly":[164],"gene.":[170],"Conclusions":[171],"gen":[173],"e":[174],"may":[176],"play":[177,198],"a":[178],"role":[180,201],"tumorigenesis":[183,205],"can":[187],"de":[188],"regulate":[189],"RCC.It":[196],"might":[197],"an":[199],"important":[200],"i":[202],"n":[203],"progression":[207],"RCC.":[209]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
