{"id":"https://openalex.org/W237648781","doi":null,"title":"Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5.","display_name":"Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W237648781","mag":"237648781","pmid":"https://pubmed.ncbi.nlm.nih.gov/25878490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4390809"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4390809","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027247545","display_name":"Margrit Hollborn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Margrit Hollborn","raw_affiliation_strings":["Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017649992","display_name":"Stefanie Vogler","orcid":"https://orcid.org/0000-0002-2474-611X","observed_orcids":["https://orcid.org/0000-0002-2474-611X"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Vogler","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045138697","display_name":"Andreas Reichenbach","orcid":"https://orcid.org/0000-0001-5398-032X","observed_orcids":["https://orcid.org/0000-0001-5398-032X"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Reichenbach","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018272749","display_name":"Peter Wiedemann","orcid":"https://orcid.org/0000-0002-5540-6847","observed_orcids":["https://orcid.org/0000-0002-5540-6847"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Wiedemann","raw_affiliation_strings":["Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006741407","display_name":"Andreas Bringmann","orcid":"https://orcid.org/0000-0001-6193-8041","observed_orcids":["https://orcid.org/0000-0001-6193-8041"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Bringmann","raw_affiliation_strings":["Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017888536","display_name":"Leon Kohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I4405271141","display_name":"Helios Klinikum Aue","ror":"https://ror.org/01y99eb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940","https://openalex.org/I4405271141"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leon Kohen","raw_affiliation_strings":["Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany ; Helios Klinikum Aue, Aue, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany ; Helios Klinikum Aue, Aue, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I4405271141","https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.0876,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.98027613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":null,"first_page":"360","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.968999981880188},{"id":"https://openalex.org/keywords/aqp5","display_name":"aquaporin 5","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aquaporin-8","display_name":"AQP8","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/retinal-pigment-epithelial-cells","display_name":"retinal pigment epithelial cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/nfat5","display_name":"NFAT5","score":0.996999979019165},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.6330000162124634},{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.8899999856948853},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.8949999809265137},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8759999871253967},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9049999713897705},{"id":"https://openalex.org/keywords/triamcinolone-acetonide","display_name":"triamcinolone acetonide","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6346839666366577},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6287927627563477},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.5982466340065002},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.584834635257721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.532871425151825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4919102191925049},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.44528311491012573},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42981332540512085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3957919776439667},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.29357534646987915},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.249067485332489},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.20832720398902893},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1685141623020172},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09538426995277405},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020346","descriptor_name":"Aquaporins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020346","descriptor_name":"Aquaporins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048052","descriptor_name":"Mitogen-Activated Protein Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051402","descriptor_name":"Aquaporin 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051402","descriptor_name":"Aquaporin 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051402","descriptor_name":"Aquaporin 5","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4390809","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:25878490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25878490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:237648781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25878490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4390809","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4390809/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W237648781.pdf","grobid_xml":"https://content.openalex.org/works/W237648781.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W840384106","https://openalex.org/W1524612163","https://openalex.org/W1539820027","https://openalex.org/W1540982890","https://openalex.org/W1545732697","https://openalex.org/W1556783877","https://openalex.org/W1565600091","https://openalex.org/W1580865462","https://openalex.org/W1970929493","https://openalex.org/W1970937193","https://openalex.org/W1972071166","https://openalex.org/W1973221286","https://openalex.org/W1976552412","https://openalex.org/W1980466416","https://openalex.org/W1984327097","https://openalex.org/W1996418653","https://openalex.org/W2000624133","https://openalex.org/W2007897471","https://openalex.org/W2018468745","https://openalex.org/W2024486369","https://openalex.org/W2026225289","https://openalex.org/W2034530918","https://openalex.org/W2035088045","https://openalex.org/W2035881395","https://openalex.org/W2039122391","https://openalex.org/W2041820145","https://openalex.org/W2044531877","https://openalex.org/W2044914889","https://openalex.org/W2056838803","https://openalex.org/W2057652942","https://openalex.org/W2060445193","https://openalex.org/W2061685766","https://openalex.org/W2065372694","https://openalex.org/W2084575920","https://openalex.org/W2086964414","https://openalex.org/W2089088191","https://openalex.org/W2093834664","https://openalex.org/W2095251996","https://openalex.org/W2111274886","https://openalex.org/W2117525838","https://openalex.org/W2117696490","https://openalex.org/W2123883528","https://openalex.org/W2124663880","https://openalex.org/W2127048642","https://openalex.org/W2142786915","https://openalex.org/W2144792936","https://openalex.org/W2146743122","https://openalex.org/W2157179744","https://openalex.org/W2160847021","https://openalex.org/W2160906502","https://openalex.org/W2163069245","https://openalex.org/W2167747754","https://openalex.org/W2170661359","https://openalex.org/W2172124430","https://openalex.org/W2186616911","https://openalex.org/W2281424226","https://openalex.org/W2330001992","https://openalex.org/W2394966073","https://openalex.org/W2411514865","https://openalex.org/W2771472252","https://openalex.org/W3198570063","https://openalex.org/W4253427643"],"related_works":["https://openalex.org/W2395288072","https://openalex.org/W2270019828","https://openalex.org/W2922438676","https://openalex.org/W2598726076","https://openalex.org/W2912603586","https://openalex.org/W7066971190","https://openalex.org/W820738555","https://openalex.org/W2563856044","https://openalex.org/W1965204440","https://openalex.org/W2054351725"],"abstract_inverted_index":{"PURPOSE:":[0],"High":[1],"intake":[2,280],"of":[3,16,46,57,77,90,117,123,136,158,167,174,182,191,196,203,215,224,237,244,259,269,295,302,311],"dietary":[4],"salt":[5,279],"increases":[6],"extracellular":[7,52],"osmolarity,":[8],"which":[9],"results":[10],"in":[11,61,101,218,282,298],"hypertension,":[12],"a":[13],"risk":[14],"factor":[15,36,122],"neovascular":[17,287],"age-related":[18],"macular":[19],"degeneration.":[20],"Neovascular":[21],"retinal":[22,64,288],"diseases":[23,289],"are":[24],"associated":[25],"with":[26,109,140,146],"edema.":[27,47,312],"Various":[28],"factors":[29],"and":[30,38,43,59,82,104,112,120,155,169,177,184,186,210,229,251,262,290],"channels,":[31],"including":[32],"vascular":[33],"endothelial":[34],"growth":[35],"(VEGF)":[37],"aquaporins":[39],"(AQPs),":[40],"influence":[41],"neovascularization":[42],"the":[44,55,88,97,156,164,172,180,188,201,222,234,256,267,293,309],"development":[45],"Therefore,":[48],"we":[49],"determined":[50,108,130,139],"whether":[51],"hyperosmolarity":[53,150],"alters":[54],"expression":[56,103,166,181,195,236,243],"VEGF":[58,152,159,197,238,270,296],"AQPs":[60],"cultured":[62],"human":[63],"pigment":[65],"epithelial":[66],"(RPE)":[67],"cells.":[68,273],"METHODS:":[69],"Human":[70],"RPE":[71,272],"cells":[72],"obtained":[73],"within":[74],"48":[75],"h":[76],"donor":[78],"death":[79],"were":[80,107,129],"prepared":[81],"cultured.":[83],"Hyperosmolarity":[84,161,254],"was":[85,138,143,198,217,246],"induced":[86,171,187],"by":[87,131,248],"addition":[89],"100":[91],"mM":[92],"NaCl":[93],"or":[94],"sucrose":[95],"to":[96],"culture":[98],"medium.":[99],"Alterations":[100],"gene":[102,153,165,257],"protein":[105],"secretion":[106,157,268],"real-time":[110],"RT-PCR":[111],"ELISA,":[113],"respectively.":[114],"The":[115,193,212,242,274,300],"levels":[116],"signaling":[118],"proteins":[119],"nuclear":[121],"activated":[124],"T":[125],"cell":[126],"5":[127],"(NFAT5)":[128],"western":[132],"blotting.":[133],"DNA":[134,189],"binding":[135,190],"NFAT5":[137,142],"EMSA.":[141],"knocked":[144],"down":[145],"siRNA.":[147],"RESULTS:":[148],"Extracellular":[149],"stimulated":[151],"transcription":[154,258],"protein.":[160],"also":[162],"increased":[163,179],"AQP5":[168,216,245,303],"AQP8,":[170,261],"phosphorylation":[173],"p38":[175,204,225],"MAPK":[176],"ERK1/2,":[178,206,227],"HIF-1\u03b1":[183],"NFAT5,":[185],"NFAT5.":[192,211,230],"hyperosmotic":[194,213,235],"dependent":[199,220],"on":[200,221],"activation":[202,223],"MAPK,":[205,226],"JNK,":[207],"PI3K,":[208],"HIF-1,":[209],"induction":[214],"part":[219],"NF-\u03baB,":[228],"Triamcinolone":[231],"acetonide":[232],"inhibited":[233],"but":[239],"not":[240],"AQP5.":[241],"decreased":[247],"hypoosmolarity,":[249],"serum,":[250],"hypoxia.":[252],"CONCLUSIONS:":[253],"induces":[255],"AQP5,":[260],"VEGF,":[263],"as":[264,266],"well":[265],"from":[271],"data":[275],"suggest":[276],"that":[277],"high":[278],"resulting":[281],"osmotic":[283],"stress":[284],"may":[285,307],"aggravate":[286],"edema":[291],"via":[292],"stimulation":[294],"production":[297],"RPE.":[299],"downregulation":[301],"under":[304],"hypoxic":[305],"conditions":[306],"prevent":[308],"resolution":[310]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}