{"id":"https://openalex.org/W237641482","doi":null,"title":"The pharmacodynamics of L-arginine.","display_name":"The pharmacodynamics of L-arginine.","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W237641482","mag":"237641482","pmid":"https://pubmed.ncbi.nlm.nih.gov/24755570"},"language":"en","primary_location":{"id":"pmid:24755570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24755570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038106053","display_name":"Rainer H. B\u00f6ger","orcid":"https://orcid.org/0000-0003-3770-5357","observed_orcids":["https://orcid.org/0000-0003-3770-5357"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rainer H B\u00f6ger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038106053"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2695,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.9442159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"3","first_page":"48","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.777999997138977},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5600000023841858},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7319999933242798},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.8813529014587402},{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.8100459575653076},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.735092282295227},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.596845805644989},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.528667688369751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.527146577835083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5155630111694336},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.48970964550971985},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4828348755836487},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.451900452375412},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.442716509103775},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.4186147451400757},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3958015441894531},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.25852102041244507},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2179383635520935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20488202571868896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16575932502746582}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:24755570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24755570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},{"id":"mag:237641482","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24755570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2010799584","https://openalex.org/W2067261577","https://openalex.org/W7097808902","https://openalex.org/W2088652661","https://openalex.org/W2159157497","https://openalex.org/W3024062720","https://openalex.org/W2117928472","https://openalex.org/W2103931005","https://openalex.org/W2118692312","https://openalex.org/W1953477778"],"abstract_inverted_index":{"L-Arginine":[0,191,203],"is":[1,10,15],"a":[2,11,18,32,41,62,78,159,187],"precursor":[3],"for":[4,167,172],"nitric":[5],"oxide":[6],"(NO)":[7],"synthesis.":[8],"NO":[9,23,29,120],"ubiquitous":[12],"mediator":[13,42],"that":[14,180],"formed":[16],"by":[17,193],"family":[19],"of":[20,43,56,71,84,107,111,137,146,183,190,237,250],"enzymes":[21],"called":[22],"synthases":[24],"(NOSs).":[25],"In":[26,130,233],"the":[27,35,48,53,57,144,162,223,235],"brain,":[28],"acts":[30,39],"as":[31,40,61],"neurotransmitter;":[33],"in":[34,47,77,90,94,118,122,150,158,209,216,264],"immune":[36],"system,":[37,50],"it":[38,51,177],"host":[44],"defense;":[45],"and":[46,64,157,247,257],"cardiovascular":[49,147],"mediates":[52],"protective":[54],"effects":[55,236,263],"intact":[58],"endothelium,":[59],"acting":[60],"vasodilator":[63],"endogenous,":[65],"antiatherogenic":[66],"molecule.":[67],"About":[68],"5":[69],"g":[70],"L-arginine":[72,85,112,138,153,170,201,221,238],"are":[73,86],"ingested":[74],"each":[75],"day":[76],"normal":[79,227],"Western":[80],"diet.":[81],"Plasma":[82],"levels":[83,182],"not":[87,155,258],"significantly":[88],"reduced":[89],"most":[91],"diseases,":[92],"except":[93],"end-stage":[95],"renal":[96],"failure":[97],"during":[98],"hemodialysis":[99],"treatment.":[100],"Nonetheless,":[101],"intravenous":[102],"or":[103],"dietary":[104],"(oral)":[105],"administration":[106,136],"relatively":[108],"large":[109],"doses":[110],"has":[113,139],"been":[114,140],"shown":[115,141],"to":[116,142,200,205,226,244,254,259],"result":[117],"enhanced":[119],"formation":[121],"individuals":[123,210],"with":[124,211,218],"impaired":[125],"endothelial":[126,231],"function":[127],"at":[128],"baseline.":[129],"several":[131],"controlled":[132],"clinical":[133],"trials,":[134,152],"long-term":[135],"improve":[143],"symptoms":[145],"disease.":[148],"However,":[149],"other":[151],"was":[154],"beneficial,":[156],"recent":[160],"study,":[161],"authors":[163],"reported":[164],"higher":[165],"mortality":[166],"participants":[168],"receiving":[169,174],"than":[171],"those":[173,217],"placebo.":[175],"Recently,":[176],"became":[178],"clear":[179],"endogenous":[181],"asymmetric":[184],"dimethylarginine":[185],"(ADMA),":[186],"competitive":[188],"inhibitor":[189],"metabolism":[192],"NOS,":[194],"may":[195],"determine":[196],"an":[197],"individual's":[198],"response":[199],"supplementation.":[202],"appears":[204],"exert":[206],"no":[207],"effect":[208],"low":[212],"ADMA":[213],"levels,":[214,220],"whereas":[215],"high":[219],"restores":[222],"L-arginine/ADMA":[224],"ratio":[225],"and,":[228],"thereby,":[229],"normalizes":[230],"function.":[232],"conclusion,":[234],"supplementation":[239],"on":[240],"human":[241],"physiology":[242],"appear":[243,253],"be":[245,255],"multicausal":[246],"dose-related.":[248],"Doses":[249],"3-8":[251],"g/d":[252],"safe":[256],"cause":[260],"acute":[261],"pharmacologic":[262],"humans.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
