{"id":"https://openalex.org/W2375831997","doi":null,"title":"[Inhibitory effect of siRNA on bcr-abl gene expression in K562 cell line].","display_name":"[Inhibitory effect of siRNA on bcr-abl gene expression in K562 cell line].","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2375831997","mag":"2375831997","pmid":"https://pubmed.ncbi.nlm.nih.gov/15228661"},"language":"zh","primary_location":{"id":"pmid:15228661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15228661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068705633","display_name":"Lei Jiang","orcid":"https://orcid.org/0000-0001-9588-2015","observed_orcids":["https://orcid.org/0000-0001-9588-2015"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Jiang","raw_affiliation_strings":["Institute of Medical Sciences, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. jianglei0299@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. jianglei0299@hotmail.com","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078315294","display_name":"Jianbo Wu","orcid":"https://orcid.org/0000-0003-3673-6477","observed_orcids":["https://orcid.org/0000-0003-3673-6477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Bo Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072823398","display_name":"Kang Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kang Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025063680","display_name":"Wu-Hua Ni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wu-Hua Ni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2133,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59164733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"3","first_page":"332","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.8190000057220459},{"id":"https://openalex.org/keywords/bcr-abl-fusion","display_name":"BCR-ABL fusion gene","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/sirna-transfection","display_name":"siRNA transfection","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.9030614495277405},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7584164142608643},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.7523282766342163},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.7275393009185791},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.6651794910430908},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.6276652812957764},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6080555319786072},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6061975359916687},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.575810968875885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4630003571510315},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4627848267555237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4508095979690552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44467028975486755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37316906452178955},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3201145529747009},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2405746877193451},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.12865230441093445},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.09569016098976135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07683193683624268}],"mesh":[{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:15228661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15228661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2384521259","https://openalex.org/W2484650223","https://openalex.org/W2351631472","https://openalex.org/W7221033649","https://openalex.org/W2041297372","https://openalex.org/W2355601388","https://openalex.org/W2409443902","https://openalex.org/W4239498620","https://openalex.org/W2378721789","https://openalex.org/W2159334925"],"abstract_inverted_index":{"To":[0],"explore":[1],"a":[2],"new":[3],"way":[4],"to":[5,61],"treat":[6],"CML,":[7],"inhibitory":[8],"effect":[9],"of":[10,20,65,105],"small":[11],"interfering":[12],"RNA":[13],"(SiRNA)":[14],"on":[15],"bcr-abl":[16,28,37,48,88,102],"fusion":[17],"gene":[18,29,38,49,89,103],"expression":[19,39,50,90,104],"K562":[21,35,81,106],"cell":[22,107],"line":[23],"was":[24,30,40,51,84],"studied.":[25],"SiRNA":[26],"for":[27],"designed":[31],"and":[32,59,63,70],"transfected":[33],"into":[34],"cells,":[36],"tested":[41],"by":[42,53],"RT-PCR.":[43],"The":[44],"results":[45],"showed":[46],"that":[47],"inhibited":[52],"using":[54],"siRNA":[55,79,98],"in":[56],"dose-dependent":[57],"manner":[58],"reduced":[60],"19.9%":[62],"26.6%":[64],"the":[66],"control":[67],"at":[68,92],"24":[69],"48":[71],"hours":[72],"after":[73],"transfection":[74],"with":[75],"0.2":[76],"micro":[77],"g":[78],"respectively.":[80],"cells":[82],"proliferation":[83],"suppressed":[85],"finally,":[86],"but":[87],"restored":[91],"72":[93],"hours.":[94],"In":[95],"conclusion,":[96],"anti-bcr-abl":[97],"can":[99],"effectively":[100],"inhibit":[101],"line.":[108]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
