{"id":"https://openalex.org/W2374843547","doi":null,"title":"Relationship between the point mutations of ERG11 gene in Candida albicans and azole antifungal agent resistance","display_name":"Relationship between the point mutations of ERG11 gene in Candida albicans and azole antifungal agent resistance","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2374843547","mag":"2374843547"},"language":"en","primary_location":{"id":"mag:2374843547","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HNZD201109016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764572692","display_name":"Journal of Chinese Practical Diagnosis and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chinese Practical Diagnosis and Therapy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006903529","display_name":"Wei-Qi Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119987","display_name":"Qingdao Municipal Hospital","ror":"https://ror.org/02jqapy19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei-Qi Su","raw_affiliation_strings":["Department of Clinical Laboratory,Qingdao Municipal Hospital,Qingdao 266011,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory,Qingdao Municipal Hospital,Qingdao 266011,China","institution_ids":["https://openalex.org/I4210119987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006903529"],"corresponding_institution_ids":["https://openalex.org/I4210119987"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30232064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9739999771118164},{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.9959999918937683},{"id":"https://openalex.org/keywords/azole-resistance","display_name":"azole resistance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.9610000252723694},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-resistant-strains","display_name":"drug-resistant strains","score":0.5519999861717224},{"id":"https://openalex.org/keywords/sterol-14alpha-demethylase","display_name":"sterol 14\u03b1-demethylase","score":0.7630000114440918},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7160000205039978},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8427327871322632},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.7439615726470947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6777775287628174},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.6641626358032227},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.5997376441955566},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5256943702697754},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47342756390571594},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.45646750926971436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43522581458091736},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4338451325893402},{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.42918288707733154},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.4243418574333191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4195288121700287},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.36389368772506714},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.24948152899742126}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2374843547","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-HNZD201109016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764572692","display_name":"Journal of Chinese Practical Diagnosis and Therapy","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chinese Practical Diagnosis and Therapy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3028752112","https://openalex.org/W2151649073","https://openalex.org/W2071718406","https://openalex.org/W7097239802","https://openalex.org/W2564016800","https://openalex.org/W2363151190","https://openalex.org/W2040810699","https://openalex.org/W2073180088","https://openalex.org/W1603981109","https://openalex.org/W3145104987"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2],"the":[3,6,28,59,70,91,104,117,132],"relationship":[4],"between":[5,113],"point":[7],"mutations":[8,128],"of":[9,33,58,65,72,78,89,99,136,143,158,165],"ERG11":[10,73,79,106,163],"gene":[11,74,164],"in":[12,120,131,141,162],"Candida":[13,34,60,168],"albicans":[14,61,169],"and":[15,36,81,85,116,126,151,170],"azole":[16],"antifungal":[17],"agent":[18],"resistance.Methods":[19],"Disc":[20],"diffusion":[21],"method":[22],"was":[23,41,62,95],"performed":[24],"to":[25,43,54],"screen":[26],"preliminarily":[27],"clinical":[29],"isolated":[30],"drug-resistant":[31,49],"strains":[32,50],"albicans.Clinical":[35],"Laboratory":[37],"Standards":[38],"Institute":[39],"M-27":[40],"used":[42],"measure":[44],"their":[45],"minimal":[46],"inhibitory":[47],"concentration.Ten":[48],"were":[51,75,83,108,129,139,153],"randomly":[52],"selected":[53],"be":[55,175],"studied.Genome":[56],"DNA":[57],"extracted.Three":[63],"pairs":[64],"PCR":[66,93],"primers":[67],"overlapping":[68],"all":[69,90],"sequence":[71,119],"synthesized.The":[76],"fragments":[77,94],"gene(P1,P2":[80],"P3)":[82],"amplified":[84],"purified.Results":[86],"The":[87],"size":[88],"three":[92],"consistent":[96],"with":[97,177],"that":[98,103,123],"expected.Sequencing":[100],"results":[101],"showed":[102,122],"complete":[105],"genes":[107],"successfully":[109],"amplified.The":[110],"aligning":[111],"analysis":[112],"acquired":[114],"sequences":[115],"standard":[118],"GenBank(X13296)":[121],"both":[124],"same-sense":[125],"missense":[127,137,159],"existed":[130],"resistant":[133],"strains.Fifteen":[134],"sites":[135,148,157],"mutation":[138,160],"proved":[140],"total":[142],"27":[144],"base":[145],"altered":[146],"sites.Five":[147],"including":[149],"F126L,I166N,H183Q,S453F":[150],"N490K":[152],"newly":[154],"probed.Conclusion":[155],"Multiple":[156],"exist":[161],"Azoles":[166],"resistance":[167],"are":[171],"multi-point":[172],"mutation,which":[173],"may":[174],"related":[176],"drug":[178],"resistance.":[179]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}